35 Results for "

N1-methyl-pseudouridine

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "N1-methyl-pseudouridine" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-112582
CAS No.: 13860-38-3
Purity:  99.95%
Synonyms: 1-methylpseudouridine; N1-methyl-pseudouridine
N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density [1].
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1
1 Cited Publications
Cat. No.: HY-134124
CAS No.: 92614-59-0
Purity:  95.8%
Research Areas:  

Metabolic Disease

Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense [1].
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1
1 Cited Publications
Cat. No.: HY-A0248A
CAS No.: 4135-11-9
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment [1] .
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1
1 Cited Publications
Cat. No.: HY-P1108
CAS No.: 681260-70-8
Target:  

CRFR

Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 [1] .
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1
1 Cited Publications
Cat. No.: HY-P1108A
Target:  

CRFR

Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 [1] .
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Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
Target:  

Ferroportin

Research Areas:  

Others

Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis [1] .
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Cat. No.: HY-P10143
CAS No.: 99828-55-4
Synonyms: Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt
Target:  

MMP

Research Areas:  

Others

MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties [1] .
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Cat. No.: HY-A0248AS
Polymyxin B1-d7 TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment [1] .
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Cat. No.: HY-P10563
CAS No.: 2580150-96-3
Synonyms: BHV-1100
Target:  

CD38 IFNAR

Research Areas:  

Cancer

Noraramtide (BHV-1100) is an antibody-recruiting molecule. Noraramtide binds to CD38 and recruits natural killer (NK) cells to mediate antibody-dependent cellular cytotoxicity. Noraramtide enhances the capacity of autologous cytokine-induced memory-like (CIML) NK cells to produce IFNγ and CD107a, thereby improving their cytotoxicity against multiple myeloma cells. Noraramtide can be used in the research of multiple myeloma [1].
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Cat. No.: HY-154366
CAS No.: 875302-45-7
Purity:  ≥98.0%
Synonyms: N1-methylpseudouridine CEP
Research Areas:  

Cancer

5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
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Cat. No.: HY-112582S
Synonyms: 1-methylpseudouridine-d3; N1-methyl-pseudouridine-d3
N1-Methylpseudouridine-d3 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
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Cat. No.: HY-185961
Target:  

mRNA

Research Areas:  

Others

saCas9 mRNA (N1-methyl-pseudouridine) is an enzyme encoding Staphylococcus aureus Cas9 (saCas9), small in size and well-suited for AAV delivery. After efficiently entering cells or animals, saCas9 mRNA (N1-methyl-pseudouridine) can be translated into protein, thereby enabling gene editing functions within the cell.
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Cat. No.: HY-P3066
CAS No.: 77453-01-1
Synonyms: d(CH2)5Tyr(Et)VAVP
Target:  

Vasopressin Receptor

Research Areas:  

Metabolic Disease

SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP [1].
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Cat. No.: HY-185959
Target:  

mRNA

Research Areas:  

Others

hEPO mRNA (N1-methyl-pseudouridine) is an enzyme encoding human erythropoietin (hEPO) used for protein expression, functional studies, and the exploration of erythropoiesis-related diseases.
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Cat. No.: HY-185955
Target:  

mRNA

Research Areas:  

Others

CBEmax mRNA (N1-methyl-pseudouridine) is an optimized cytosine base editor, CBEmax, that converts C·G to T·A for precise base editing and disease model research.
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Cat. No.: HY-185974
Target:  

mRNA

Research Areas:  

Others

ParTasR mRNA (N1-methyl-pseudouridine) is a nuclease encoding the TIGR-Tas system nuclease ParTasR. Guided by tigRNA, it cleaves DNA without the need for PAM, enabling novel gene editing.
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Cat. No.: HY-185966
Target:  

mRNA

Research Areas:  

Others

tdTomato mRNA (N1-methyl-pseudouridine) is a bright red fluorescent protein, tdTomato, used for fluorescent labeling, cell tracking, and expression detection. Its excitation and emission peaks are at 554 nm and 581 nm, respectively.
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Cat. No.: HY-185956
Target:  

mRNA

Research Areas:  

Others

eSpCas9 mRNA (N1-methyl-pseudouridine) is a high-fidelity version of SpCas9 with lower off-target rates while maintaining high targeted genome editing efficiency.
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Cat. No.: HY-185971
Target:  

mRNA

Research Areas:  

Others

PiggyBac mRNA V2 (N1-methyl-pseudouridine) is an enzyme encoding PiggyBac transposase, mediating efficient transgene integration and scarless excision, used for transgenic and cell engineering.
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Cat. No.: HY-185964
Target:  

mRNA

Research Areas:  

Others

Beta-gal mRNA (N1-methyl-pseudouridine) is an enzyme encoding β-galactosidase, used as a reporter gene, and its expression can be detected by X-gal staining.
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