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Results for "

1,3-Beta-glucan synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (6) Fungal (7) Glycosyltransferase (1)
By Research Areas:	Infection (7) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Targets Recommended: PGE synthase Acetolactate Synthase (ALS) Thymidylate Synthase Cellulose Synthase ATP Synthase GSK-3 Fatty Acid Synthase (FASN) Glucosylceramide Synthase (GCS) Cyclic GMP-AMP Synthase NO Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E71154

**1,3-β-Glucan synthase**	Glycosyltransferase	Metabolic Disease
1,3-β-Glucan synthase (EC 2.4.1.34) belongs to the family of glycosyltransferases, specifically the hexosyltransferases.

HY-N5160

Arborcandin A	Antibiotic Fungal	Infection
Arborcandin A is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin A exhibits IC₅₀** values of 0.25 μg/mL and 0.05 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin A has an MIC of 4-8 μg/mL against the genus Candida .

HY-N5165

Arborcandin F	Antibiotic Fungal	Infection
Arborcandin F is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin F exhibits IC₅₀** values of 0.012 μg/mL against both Candida albicans and Aspergillus fumigatus. Additionally, Arborcandin F has an MIC of 2-4 μg/mL against the genus Candida .

HY-N5163

Arborcandin D	Antibiotic Fungal	Infection
Arborcandin D is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin D exhibits IC₅₀** values of 3 μg/mL and 0.35 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin D has an MIC of 4 μg/mL against the genus Candida .

HY-N5162

Arborcandin C	Antibiotic Fungal	Infection
Arborcandin C is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin C exhibits IC₅₀** values of 0.15 μg/mL and 0.015 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin C has an MIC of 1-2 μg/mL against the genus Candida .

HY-N5161

Arborcandin B	Antibiotic Fungal	Infection
Arborcandin B is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin B exhibits IC₅₀** values of 0.30 μg/mL and 0.025 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin B has an MIC of 2-4 μg/mL against the genus Candida .

HY-N5164

Arborcandin E	Antibiotic Fungal	Infection
Arborcandin E is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin E exhibits IC₅₀** values of 0.1 μg/mL and 0.012 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin E has an MIC of 0.5-2 μg/mL against the genus Candida .

HY-180483

Antifungal agent 144	Fungal	Infection
Antifungal agent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with an MIC of 7.5 μg/mL. Antifungal agent 144 simultaneously inhibits chitin deacetylase AngCDA and **1,3-β-glucan synthase*. Antifungal agent 144 functions by disrupting the integrity of the fungal cell wall and does not bind to Ergosterol (HY-N0181). Antifungal agent 144 can be used for research on Aspergillus niger* infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5160

Arborcandin A	Natural Products Microorganisms Source Classification	Antibiotic Fungal
Arborcandin A is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin A exhibits IC₅₀** values of 0.25 μg/mL and 0.05 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin A has an MIC of 4-8 μg/mL against the genus Candida .

HY-N5165

Arborcandin F	Natural Products Microorganisms Source Classification	Antibiotic Fungal
Arborcandin F is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin F exhibits IC₅₀** values of 0.012 μg/mL against both Candida albicans and Aspergillus fumigatus. Additionally, Arborcandin F has an MIC of 2-4 μg/mL against the genus Candida .

HY-N5163

Arborcandin D	Natural Products Microorganisms Source Classification	Antibiotic Fungal
Arborcandin D is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin D exhibits IC₅₀** values of 3 μg/mL and 0.35 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin D has an MIC of 4 μg/mL against the genus Candida .

HY-N5162

Arborcandin C	Natural Products Microorganisms Source Classification	Antibiotic Fungal
Arborcandin C is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin C exhibits IC₅₀** values of 0.15 μg/mL and 0.015 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin C has an MIC of 1-2 μg/mL against the genus Candida .

HY-N5161

Arborcandin B	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Fungal
Arborcandin B is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin B exhibits IC₅₀** values of 0.30 μg/mL and 0.025 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin B has an MIC of 2-4 μg/mL against the genus Candida .

HY-N5164

Arborcandin E	Natural Products Microorganisms Source Classification	Antibiotic Fungal
Arborcandin E is a **1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin E exhibits IC₅₀** values of 0.1 μg/mL and 0.012 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin E has an MIC of 0.5-2 μg/mL against the genus Candida .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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1,3-Beta-glucan synthase

Inhibitors & Agonists

NaturalProducts

Natural
Products