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Results for "

12-Lipoxygenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) AP-1 (1) Apoptosis (1) COX (3) DNA/RNA Synthesis (1) ERK (1) Interleukin Related (1) Leukotriene Receptor (1) Lipoxygenase (9) NF-κB (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Inflammation/Immunology (9) Metabolic Disease (3) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Protéines recombinantes

Antibodies

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-12341

ML355 5+ Cited Publications	Lipoxygenase	Inflammation/Immunology
ML355 is a potent and selective inhibitor of **12-Lipoxygenase (12-LOX) with an IC₅₀** of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties.

HY-124404A

12(S)-HETE	ERK DNA/RNA Synthesis p38 MAPK	Cancer
12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	COX Lipoxygenase Apoptosis	Cardiovascular Disease Inflammation/Immunology
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and *12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase*, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-13219

Tepoxalin	COX Lipoxygenase Reactive Oxygen Species (ROS) NF-κB	Neurological Disease Inflammation/Immunology
Tepoxalin is an orally active dual inhibitor of *Cyclooxygenase/Lipoxygenase*, with IC₅₀ values of 4.6 μM (sheep cyclooxygenase), 2.85 μM (rat cyclooxygenase), 0.15 μM (rat 5-lipoxygenase), and 3.0 μM (h12-lipoxygenase), respectively. Tepoxalin inhibits ROS production and NF-κB activation. Tepoxalin suppresses the production of thromboxane B₂, leukotriene B₄, prostaglandins and cytokines, and blocks platelet aggregation. Tepoxalin exhibits potent anti-inflammatory activity in rats with adjuvant-induced arthritis. Tepoxalin possesses analgesic activity. Tepoxalin shows no ulcerogenic activity within the anti-inflammatory dose range. Tepoxalin can be used in studies related to adjuvant-induced arthritis, skin inflammation and Alzheimer's disease .

HY-119684

Maresin 2	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Maresin 2 is an anti-inflammatory and pro-resolving mediator. Maresin 2 drives intestinal epithelial cell migration by activating the focal cell-matrix adhesion signaling pathway in primary human intestinal epithelial cells, thereby promoting mucosal wound repair. Maresin 2 alleviates nociceptive and anxiety-like behaviors in rats with type 1 diabetes by inhibiting IL-1β in the spinal cord and prefrontal cortex. Maresin 2 attenuates allergic airway inflammation in mice by inhibiting the activation of the NLRP3 inflammasome, Th2-type immune responses, and oxidative stress. Maresin 2 inhibits inflammatory and neuropathic trigeminal neuralgia and reduces neuronal activation in the trigeminal ganglion. Maresin 2 promotes inflammation resolution and mucosal repair after DSS-induced colitis or biopsy-induced colonic mucosal injury .

HY-121585

CAY10698	Lipoxygenase	Inflammation/Immunology
CAY10698 (compound 1) is a potent and selective inhibitor of **12-Lipoxygenase (12-LOX) with an IC₅₀** of 5.1 μM. CAY10698 is inactive against 5-LOX, 15-LOX-1, 15-LOX-2 and COX-1/2 .

HY-101051

2-TEDC 1 Publications Verification	Lipoxygenase	Cardiovascular Disease Metabolic Disease
2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC₅₀ values of 0.09 μM, 0.013 μM and 0.5 μM, respectively. 2-TEDC can be used for the research of atheroscrelosi .

HY-139055

NCTT-956	Lipoxygenase	Inflammation/Immunology
NCTT-956 is a very effective platelet 12-lipoxygenase (12-LOX) activity-specific inhibitor .

HY-150191

IMA-1	Lipoxygenase Acetyl-CoA Carboxylase	Metabolic Disease
IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1). IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH .

HY-113443

12(S)-HPETE	AP-1	Metabolic Disease
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

HY-125122

Mulberrofuran A	Others	Inflammation/Immunology
Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product) .

HY-131384

8,11,14-Eicosatriynoic acid 8,11,14-Icosatriynoic acid	COX	Others
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-182696

CGS 24891	Lipoxygenase	Inflammation/Immunology
CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC₅₀ value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B₄ (LTB₄) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC₅₀ of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions .

HY-182422

CGS 23885	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
CGS 23885 is an orally active 5-lipoxygenase (5-lipoxygenase) inhibitor. CGS 23885 reduces the production of 5-hydroxyeicosatetraenoic acid (5-hydroxyeicosatetraenoic acid), LTB₄, and LTC₄/D₄/E₄. CGS 23885 inhibits cell infiltration in rat pleurisy. CGS 23885 can be used in pleurisy-related research .

Cat. No.	Nom du produit	Type

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	Biochemical Assay Reagents
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and *12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase*, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

trans-2-Nonenal

trans-2-Nonen-1-al

Biochemical Assay Reagents

trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-131384

8,11,14-Eicosatriynoic acid 8,11,14-Icosatriynoic acid	Biochemical Assay Reagents
8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Nom du produit	Category	Target	Chemical Structure

HY-124404A

12(S)-HETE	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	ERK DNA/RNA Synthesis p38 MAPK
12(S)-HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12(S)-HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells .

HY-W089800

trans-2-Nonenal trans-2-Nonen-1-al	Source Classification	COX Lipoxygenase Apoptosis
trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and *12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase*, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .

HY-113443

12(S)-HPETE	Microorganisms Source Classification	AP-1
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

HY-125122

Mulberrofuran A	Monophenols Phenols Morus alba L. Plants Moraceae Source Classification	Others
Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product) .

Species:	Human (1)
Tag:	His (2) Flag (1) CL7 (1)
Source:	E. coli (2)

Cat. No.	Compare	Nom du produit	Species	Source	Image

HY-P72076

	ALOX12 Protein, Human (His) 1 Publications Verification 12 LOX; 12S; Lipoxygenase ; 12-Lipoxygenase; 12LO; 12S LOX; 12S-Lipoxygenase; 12S-LOX; 12S-type; Alox12; Arachidonate 12 Lipoxygenase; Arachidonate 12 Lipoxygenase, 12S type; Arachidonate 12-Lipoxygenase; Arachidonate 12-oxidoreductase; Lipoxin synthase 12-LO; LOG12; LOX12_HUMAN; P-12LO; Platelet 12-LOX; Platelet type Lipoxygenase 12 ; platelet-type 12-Lipoxygenase; Platelet-type Lipoxygenase 12	Human	E. coli
	ALOX12 Protein, Human (His) is a recombinant ALOX12 protein with a His tag. ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins.

HY-P703511

	lipoxygenase Protein, Pseudomonas aeruginosa (Flag, His, CL7) Linoleate 9/13-Lipoxygenase; Oleate 10S-Lipoxygenase; 1.13.11.77; lox; Pseudomonas aeruginosa; Dioxygenase; Oxidoreductase; 1.13.11.12	Others	E. coli
	The lipoxygenase protein catalyzes the oxygen-mediated conversion of linoleic acid to 9HPOD and spontaneously decomposes it into 9HOD. It converts linolenic acid into 13HPOD, which breaks down into 13HOD. lipoxygenase Protein, Human (Flag, His, CL7) is the recombinant human-derived lipoxygenase, expressed by E. coli, with CL7, His, Flag labeled tag.

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HY-P82293

	12 Lipoxygenase Antibody (YA2038) 12 LOX; 12LO; 12S LOX; 12S-Lipoxygenase; 12S-LOX; Alox12; LOG12; P-12LO	WB	Human, Rat
	12 Lipoxygenase Antibody (YA2038) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 12 Lipoxygenase.

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12-Lipoxygenase

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Protéines recombinantes

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Natural
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