2315406-63-2
Chemical Structure
IMA-1
- CAS No.: 2315406-63-2
- Formula:C27H27N3O10S2
- Molecular Weight:617.65
IUPAC Name: 3-(3,3-dimethyl-1-phenyl-1,3-dihydrobenzo[c]thiophen-1-yl)-N-methylpropan-1-amine
InChIKey: IJHAWIVSNAFQIO-SNYRDRRFSA-N
SMILES: O=S(C(C=C1)=CC=C1NCC(C=CC=C2OC)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)(NC4=NC5=CC=CC=C5S4)=O
Biological Activity: IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1). IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH[1].
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IMA-1 | IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1). IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH. | |||||||||||||||||||||
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