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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
ACLY-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "ACLY-IN-1" in MCE Product Catalog:
Cat. No.: HY-172914
CAS No.: 2897695-26-8
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ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC50 = 8.3 nM) and high binding affinity (KD = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect [1].
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5 Cited Publications
Cat. No.: HY-18700
CAS No.: 1440209-96-0
BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 µM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin .
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1 Cited Publications
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Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0)), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gaucher’s disease (GD) and Krabbe’s disease (KD) [1].
Cat. No.: HY-P99964
CAS No.: 1824663-82-2
Synonyms: AGS15C; Ha15-10ac12; Ha15-10ac12.1
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Cat. No.: HY-W145622
CAS No.: 754954-71-7
Synonyms: Gal beta(1-3)[Neu5Ac alpha(2-6)]GlcNAc-beta-pNP
Cat. No.: HY-P10522
CAS No.: 106128-97-6
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Cat. No.: HY-W096146
CAS No.: 944561-45-9
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Propynyl-PEG1-Ac is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Propynyl-PEG1-Ac is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-P10525
CAS No.: 167278-49-1
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Cat. No.: HY-P1734
CAS No.: 125366-42-9
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Cat. No.: HY-150658S
Cat. No.: HY-P0211
CAS No.: 93965-89-0
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Cat. No.: HY-E70621
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Sialic acid aldolase (Pm NaNa) (EC 4.1.3.3) is a type I aldolase that catalyze the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) to form pyruvate and N-acetyl-D-mannosamine (ManNAc) with the equilibrium favoring the Neu5Ac cleavage .
Cat. No.: HY-W145540
CAS No.: 1316822-90-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
