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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
ADP ribosylation
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "ADP ribosylation" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: NAV-2729
Grassofermata is a dual Arf1/Arf6 activation inhibitor. ADP ribosylation factors (Arfs) are members of the Arf family of GTP-binding proteins of the Ras superfamily.
11
Target:
Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 . Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .
2
2 Cited Publications
Target:
Domaines de recherche:
QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 activates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells .
2
2
2 Cited Publications
Target:
Domaines de recherche:
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .
1
1 Cited Publications
Synonyms: MIBG sulfate; Iobenguane sulfate
Target:
Domaines de recherche:
m-Iodobenzylguanidine sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated m-Iodobenzylguanidine sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. m-Iodobenzylguanidine sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation) .
Synonyms: ε-NAD
Domaines de recherche:
Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions .
Cat. No.: HY-100767
CAS No.: 148892-91-5
Synonyms: Guanosine 5'-[β,γ-imido]triphosphate trisodium
Target:
Domaines de recherche:
RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation .
Cat. No.: HY-P99034
CAS No.: 1622075-65-3
Cat. No.: HY-131009A
Domaines de recherche:
Fluorescein-NAD + sodium is a fluorescent NAD + analog that can be used in studies related to the detection of ADP-ribosylation reactions. Fluorescein-NAD + sodium enables visualization of ADP-ribose groups, thereby facilitating the detection of ADP-ribosylation reactions. Fluorescein-NAD + sodium serves as a substrate for detecting the auto-ribosylation activity of SIRT6 and the ADP-ribosylation of RhoA by C3larvin toxin .
Cat. No.: HY-E70238
CAS No.: 126609-61-8
Synonyms: Nicotinamide 2-azidoadenine dinucleotide
Target:
Domaines de recherche:
2-Azido-NAD is a NAD + analog that can be used for visualization of intracellular Poly(ADP ribos)ylation (PARylation) processes .
Cat. No.: HY-165040
CAS No.: 20296-26-8
Synonyms: DG(16:0/18:0/0:0); 1-Palmitin-2-Stearin
1-Palmitoyl-2-stearoyl-rac-glycerol (DG(16:0/18:0/0:0)) is a compound mentioned in the study of the activation of ADP-ribosylation factor 1 GTPase activating protein by phosphatidylcholine-derived diacylglycerol, and related studies have shown that it may be involved in certain feedback mechanisms within cells.
Cat. No.: HY-137592A
Synonyms: ε-NAD sodium
Target:
Domaines de recherche:
Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) sodium, a fluorescent analogue of NAD, is able to serve as a substrate for the bacterial toxincatalyzed G-ADP ribosylation of signal-transducing G-proteins. Nicotinamide 1,N6-ethenoadenine dinucleotide sodium can be used as a fluorescent substrate for the studies of the ADP ribosylation reaction .
Cat. No.: HY-134355
CAS No.: 53595-18-9
ADPRP is an intranuclear enzyme whose main activity is to use NAD+ (nicotinamide adenine dinucleotide) as a substrate to add ADP-ribose units to chromatin-bound proteins, including the ADPRP enzyme itself. This process, called poly(ADP-ribosylation), is a post-translational modification that regulates the interaction between DNA and nuclear proteins .
Cat. No.: HY-100540A
CAS No.: 1005036-73-6
Synonyms: (Rac)-GCA
Target:
Domaines de recherche:
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. Golgicide A (GCA) is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF) GBF1 .Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species .
Cat. No.: HY-135218
CAS No.: 27296-05-5
Target:
Domaines de recherche:
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .
Cat. No.: HY-129040AR
CAS No.: 87862-25-7
Synonyms: MIBG sulfate (Standard); Iobenguane sulfate (Standard)
Domaines de recherche:
m-Iodobenzylguanidine (sulfate) (Standard) is the analytical standard of m-Iodobenzylguanidine (sulfate). This product is intended for research and analytical applications. m-Iodobenzylguanidine sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated m-Iodobenzylguanidine sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. m-Iodobenzylguanidine sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation) .
Cat. No.: HY-172747
CAS No.: 2580941-64-4
TNKS-2-IN-3 (Compound 5) is a selective competitive tankyrase 2 (TNKS2) inhibitor with an IC50 value of 0.3 nM, showing over 20-fold selectivity over TNKS1 and more than 100-fold selectivity over PARP1/2. TNKS-2-IN-3 stabilizes axin and suppresses the Wnt/β-catenin pathway by inhibiting TNKS2-mediated ADP-ribosylation, exhibiting antiproliferative activity in colorectal cancer cells. TNKS-2-IN-3 is proming for rasearch of solid tumors with aberrant Wnt pathway activation, such as colorectal cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
