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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
AKR1B1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "AKR1B1" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: Glucogallin; 1-O-Galloyl-β-D-glucose
1
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Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .
1
1 Cited Publications
Cat. No.: HY-N0310
CAS No.: 51330-27-9
Cat. No.: HY-N0412
CAS No.: 117479-87-5
Category:
Iridoids Labiatae Terpenoids Phaseolus lunatus L. Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-RS17235
Target:
Research Areas:
Akr1b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Akr1b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00532
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AKR1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23688
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Research Areas:
Akr1b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Akr1b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-149254
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Research Areas:
PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.06 μM and 4.3 μM, respectively. PTP1B/AKR1B1-IN-1 also inhibits TC-PTP with an IC50 value of 9 μM. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus (T2DM) to control blood glucose levels .
Cat. No.: HY-149255
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PTP1B/AKR1B1-IN-2 (Compound 7f) is a dual PTP1B/AKR1B1 inhibitor (IC50s: 3.2 and 2.1 μM, Kis: 4.0 and 0.9μM). PTP1B/AKR1B1-IN-2 is an insulin-mimetic agent. PTP1B/AKR1B1-IN-2 improves glucose uptake in murine C2C12 myoblasts. PTP1B/AKR1B1-IN-2 can be used for research of Type 2 diabetes mellitus (T2DM) .
Cat. No.: HY-176719
CAS No.: 2632263-80-8
Research Areas:
AKR1B1/STAT3/SLC7A11-regulator-1 (5a) is an AKR1B1/STAT3/SLC7A11 regulator that reverses DOX resistance in MCF-7/ADR cells by enhancing ferroptosis activity. AKR1B1/STAT3/SLC7A11-regulator-1 can be used in breast cancer research .
Cat. No.: HY-175331
CAS No.: 59935-47-6
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ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (Ki=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers .
Cat. No.: HY-177415
CAS No.: 2353515-08-7
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JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI) .
Cat. No.: HY-N0310R
CAS No.: 51330-27-9
Cat. No.: HY-175639
Target:
Research Areas:
ALR2-IN-8 is a potent aldose reductase (ALR2/AKR1B1) inhibitor with a KI of 7.34 nM. ALR2-IN-8 has extremely low toxicity to normal cells and has a weak direct killing effect on cancer cells. ALR2-IN-8 can used for the studies of diabetic and inflammation-linked disorders .
Cat. No.: HY-P75521
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AKR1B1; ALR2; Prev. ALDR1; Lii5-2 CTCL Tumor Antigen; Aldose Reductase; Low Km Aldose Reductase; AR; Aldehyde Reductase 1; Aldo-Keto Reductase Family 1 Member B1; ADR; Aldehyde Reductase; Aldo-Keto Reductase Family 1 Member B; Aldo-Keto Reductase Family 1
Species:
Human
Source:
E. coli
Cat. No.: HY-106697R
CAS No.: 72702-95-5
Synonyms: ICI 128436 (Standard)
Target:
Research Areas:
Ponalrestat (Standard) (ICI 128436 (Standard)) is the analytical standard of Ponalrestat (HY-106697). This product is intended for research and analytical applications. Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .
Cat. No.: HY-P85558
Synonyms: ADR; AKR1B 1; AKR1B1; Aldehyde reductase 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1; aldose reductase; Aldose reductase; aldr 1; ALDR_HUMAN; ALDR1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km aldose reductase; MGC1804.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
