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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
APE1/APEX1+Inhibitors
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "APE1/APEX1+Inhibitors" in MCE Product Catalog:
4
Research Areas:
Erenapursta (E3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. Erenapursta is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. Erenapursta shows anticancer activities [1] .
2
2 Cited Publications
Cat. No.: HY-W014622
CAS No.: 6960-45-8
Target:
Research Areas:
CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds [1].
2
Hycanthone is an apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor, DNA intercalator and Antischistosomal agent, with an IC50 of 80 nM against APE1. Hycanthone irreversibly inhibits thymidine incorporation into DNA in adult sensitive *Schistosoma mansoni*, while exerts weak inhibitory effects on uridine and leucine incorporation. Hycanthone reduces influenza virus-induced interferon production. Hycanthone exhibits mutagenic effects in various organisms, shows teratogenicity in mice and rabbits, and induces neoplastic liver lesions in partially hepatectomized mice. Hycanthone can be used in research related to schistosomiasis and cancer [1] .
1
1 Cited Publications
Cat. No.: HY-P7523
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: APEX1; APE1; Prev. APEX; DNA-(Apurinic Or Apyrimidinic Site) Endonuclease; APEN; APEX Nuclease; REF-1; APEX Nuclease (Multifunctional DNA Repair Enzyme); REF1; Deoxyribonuclease (Apurinic Or Apyrimidinic); HAP1; Apurinic/Apyrimidinic (Abasic) Endonuclease
Species:
Human
Source:
E. coli
Target:
Research Areas:
APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells [1].
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals [1].
Cat. No.: HY-120069
CAS No.: 1415030-15-7
APX2009 is a specific APE1/REF-1 redox inhibitor with anticancer activities which decreases the proliferative, migratory, and invasive properties of breast cancer cell and induces apoptosis in breast cancer cell [1].
Cat. No.: HY-119993
CAS No.: 510721-85-4
Synonyms: BMH-23
Target:
Research Areas:
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells [1].
Cat. No.: HY-149442
CAS No.: 1227098-30-7
Target:
Research Areas:
APE1-IN-3 (Compound 1) is a APE1 inhibitor. APE1-IN-3 can be used for the research of cancer [1].
Cat. No.: HY-179014
Target:
Research Areas:
OGG1 activator-1 (Compound 30) is a selective 8-oxoguanine DNA glycosylase-1 (OGG1) activator with an AC50 value of 0.58 μM. OGG1 activator-1 does not activate nor inhibit the key downstream repair enzyme APE1, and shows > 150-fold selectivity for the activation effect on OGG1. OGG1 activator-1 exhibits extremely high metabolic stability and almost no cytotoxicity. OGG1 activator-1 can be used for the study of oxidative stress-related diseases (such as neurodegenerative diseases, fibrotic diseases, cancer, inflammation, etc.) [1].
Target:
Research Areas:
Lucanthone N-oxide is the nitrogen oxide of Lucanthone (HY-B2098), an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) [1].
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Research Areas:
Lucanthone (Standard) is the analytical standard of Lucanthone. This product is intended for research and analytical applications. Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
Cat. No.: HY-176996
CAS No.: 1136839-60-5
Target:
Research Areas:
Ape1/Ref-1 redox-IN-1 (Compound 52) is an Ape1/Ref-1 redox inhibitor. Ape1/Ref-1 redox-IN-1 can be used in the research of cancer [1].
Hycanthone (Standard) is the analytical standard of Hycanthone (HY-B1099). This product is intended for research and analytical applications. Hycanthone is an apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor, DNA intercalator and Antischistosomal agent, with an IC50 of 80 nM against APE1. Hycanthone irreversibly inhibits thymidine incorporation into DNA in adult sensitive *Schistosoma mansoni*, while exerts weak inhibitory effects on uridine and leucine incorporation. Hycanthone reduces influenza virus-induced interferon production. Hycanthone exhibits mutagenic effects in various organisms, shows teratogenicity in mice and rabbits, and induces neoplastic liver lesions in partially hepatectomized mice. Hycanthone can be used in research related to schistosomiasis and cancer [1] .
Cat. No.: HY-B1099A
CAS No.: 23255-93-8
Hycanthone mesylate is an apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor, DNA intercalator and Antischistosomal agent, with an IC50 of 80 nM against APE1. Hycanthone mesylate irreversibly inhibits thymidine incorporation into DNA in adult sensitive *Schistosoma mansoni*, while exerts weak inhibitory effects on uridine and leucine incorporation. Hycanthone mesylate reduces influenza virus-induced interferon production. Hycanthone mesylate exhibits mutagenic effects in various organisms, shows teratogenicity in mice and rabbits, and induces neoplastic liver lesions in partially hepatectomized mice. Hycanthone mesylate can be used in research related to schistosomiasis and cancer [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
