2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. AR03

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.

For research use only. We do not sell to patients.

AR03 Chemical Structure

AR03 Chemical Structure

CAS No. : 510721-85-4

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AR03 Related Antibodies

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Description

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].

IC50 & Target

IC50: 2.1 µM (Ape1)[1]
Molecular Weight

237.30

Formula

C15H15N3
CAS No.
SMILES

CC1=C2N=C3N=C(C=C(C3=C(C2=CC=C1)N)C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AR03 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR03510721-85-4BMH-23AR 03AR-03BMH23BMH 23DNA/RNA Synthesisdouble-stranded DNAcytotoxicitymethyl methanesulfonatetemozolomideSF767Inhibitorinhibitorinhibit

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