2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. AR03

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.

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AR03

AR03 Chemical Structure

CAS No. : 510721-85-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
Solid
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Description

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].

IC50 & Target

IC50: 2.1 µM (Ape1)[1]
Molecular Weight

237.30

Formula

C15H15N3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=C2N=C3N=C(C=C(C3=C(C2=CC=C1)N)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 24.1 mg/mL (101.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2141 mL 21.0704 mL 42.1407 mL
5 mM 0.8428 mL 4.2141 mL 8.4281 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.1%

SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2141 mL 21.0704 mL 42.1407 mL 105.3519 mL
5 mM 0.8428 mL 4.2141 mL 8.4281 mL 21.0704 mL
10 mM 0.4214 mL 2.1070 mL 4.2141 mL 10.5352 mL
15 mM 0.2809 mL 1.4047 mL 2.8094 mL 7.0235 mL
20 mM 0.2107 mL 1.0535 mL 2.1070 mL 5.2676 mL
25 mM 0.1686 mL 0.8428 mL 1.6856 mL 4.2141 mL
30 mM 0.1405 mL 0.7023 mL 1.4047 mL 3.5117 mL
40 mM 0.1054 mL 0.5268 mL 1.0535 mL 2.6338 mL
50 mM 0.0843 mL 0.4214 mL 0.8428 mL 2.1070 mL
60 mM 0.0702 mL 0.3512 mL 0.7023 mL 1.7559 mL
80 mM 0.0527 mL 0.2634 mL 0.5268 mL 1.3169 mL
100 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0535 mL
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AR03 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR03510721-85-4BMH-23AR 03AR-03BMH23BMH 23DNA/RNA Synthesisdouble-stranded DNAcytotoxicitymethyl methanesulfonatetemozolomideSF767Inhibitorinhibitorinhibit

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