2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. AR03

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells.

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AR03

AR03 構造式

CAS 番号 : 510721-85-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 209 在庫あり
Solution
10 mM * 1 mL in DMSO USD 209 在庫あり
Solid
5 mg $190 在庫あり
10 mg $300 在庫あり
25 mg $540 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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AR03 関連抗体

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DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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製品説明

AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].

IC50 & Target

IC50: 2.1 µM (Ape1)[1]
分子量

237.30

分子式

C15H15N3
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=C2N=C3N=C(C=C(C3=C(C2=CC=C1)N)C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 24.1 mg/mL (101.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2141 mL 21.0704 mL 42.1407 mL
5 mM 0.8428 mL 4.2141 mL 8.4281 mL
10 mM 0.4214 mL 2.1070 mL 4.2141 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.1%

COA (250 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2141 mL 21.0704 mL 42.1407 mL 105.3519 mL
5 mM 0.8428 mL 4.2141 mL 8.4281 mL 21.0704 mL
10 mM 0.4214 mL 2.1070 mL 4.2141 mL 10.5352 mL
15 mM 0.2809 mL 1.4047 mL 2.8094 mL 7.0235 mL
20 mM 0.2107 mL 1.0535 mL 2.1070 mL 5.2676 mL
25 mM 0.1686 mL 0.8428 mL 1.6856 mL 4.2141 mL
30 mM 0.1405 mL 0.7023 mL 1.4047 mL 3.5117 mL
40 mM 0.1054 mL 0.5268 mL 1.0535 mL 2.6338 mL
50 mM 0.0843 mL 0.4214 mL 0.8428 mL 2.1070 mL
60 mM 0.0702 mL 0.3512 mL 0.7023 mL 1.7559 mL
80 mM 0.0527 mL 0.2634 mL 0.5268 mL 1.3169 mL
100 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0535 mL
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AR03 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR03510721-85-4BMH-23AR 03AR-03BMH23BMH 23DNA/RNA Synthesisdouble-stranded DNAcytotoxicitymethyl methanesulfonatetemozolomideSF767Inhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-119993
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