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Asn

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1895

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4

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7

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2075

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4

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50

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55

Isotope-Labeled Compounds

6

Click Chemistry

9

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0667
    L-Asparagine
    5 Publications Verification

    (-)-Asparagine; Asn; Asparamide

    		 Endogenous Metabolite Apoptosis DNA/RNA Synthesis Inflammation/Immunology
    L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
    L-Asparagine
  • HY-128946
    CL2A-SN-38
    5 Publications Verification

    		 Drug-Linker Conjugates for ADC Inflammation/Immunology Cancer
    CL2A-SN-38 is a agent-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody agent conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A-SN-38 uses hydrolyzable linker to deliver active agents within tumor cells and in the tumor microenvironment, resulting in bystander effects .
    CL2A-SN-38
  • HY-136626
    Z-Ala-Ala-Asn-AMC
    3 Publications Verification

    Cbz-Ala-Ala-Asn-AMC

    		 Fluorescent Dye Cancer
    Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC .
    Z-Ala-Ala-Asn-AMC
  • HY-136579
    ASN007
    5 Publications Verification

    ERK-IN-3

    		 ERK Cancer
    ASN007 (ERK-IN-3) is a potent and orally active inhibitor of ERK. ASN007 inhibits ERK1/2 with low single-digit nM IC50 values. ASN007 exhibits significant anti proliferative activity against various tumor cells. ASN007 can be used for the research of cancers driven by RAS mutations .
    ASN007
  • HY-103018
    Gusacitinib
    1 Publications Verification

    Asn-002

    		 JAK Syk Inflammation/Immunology Cancer
    Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .
    Gusacitinib
  • HY-W002327
    Fmoc-Asn(Trt)-OH

    		Biochemical Assay Reagents Others
    Fmoc-Asn (Trt)-OH is an Fmoc-protected asparagine derivative. Fmoc-Asn (Trt)-OH supports solid-phase peptide synthesis .
    Fmoc-Asn(Trt)-OH
  • HY-W009085
    Fmoc-Asn-OH

    		Amino Acid Derivatives Others
    Fmoc-Asn-OH is an asparagine derivative .
    Fmoc-Asn-OH
  • HY-P4385
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)

    		PTHR Metabolic Disease
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist and does not display any partial agonist activity .
    (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat)
  • HY-N0667S2
    L-Asparagine-15N2 monohydrate
    1 Publications Verification

    (-)-Asparagine-15N2 monohydrate; Asn-15N2 monohydrate; Asparamide-15N2 monohydrate

    		 Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis Inflammation/Immunology
    L-Asparagine- 15N2 monohydrate is the 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
    L-Asparagine-15N2 monohydrate
  • HY-E70068
    Endo-β-N-acetylglucosaminidase (Endo S)

    		Others Others
    Endo-β-N-acetylglucosaminidase (Endo S) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Endo-β-N-acetylglucosaminidase (Endo S) exclusively hydrolyzes the β-1,4-di-N-acetylchitobiose core of the asparagine-linked complex-type glycan on Asn-297 of the γ-chains of IgG antibody .
    Endo-β-N-acetylglucosaminidase (Endo S)
  • HY-14874
    Topiroxostat
    5+ Cited Publications

    FYX-051

    		 MOFs Xanthine Oxidase Cytochrome P450 Metabolic Disease
    Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment .
    Topiroxostat
  • HY-N9446
    H-Asn(glcnac-beta-D)-OH

    		Endogenous Metabolite Others
    H-Asn(glcnac-beta-D)-OH is an endogenous metabolite present in Urine that can be used for the research of NGLY1-CDDG .
    H-Asn(glcnac-beta-D)-OH
  • HY-156586
    Egalognastat

    Asn90

    		 OGA Tau Protein Neurological Disease
    Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) .
    Egalognastat
  • HY-W010378
    D-Asparagine

    H-D-Asn-OH

    		 Endogenous Metabolite Metabolic Disease
    D-Asparagine (H-D-Asn-OH) acts as a competitive inhibitor of L-asparagine hydrolysis, with a Ki value of 0.24 mM. D-Asparagine serves as a nitrogen source for yeast strains. D-Asparagine is a good substrate for external yeast asparaginase but a poor substrate for internal yeast asparaginase .
    D-Asparagine
  • HY-114174
    Fmoc-Ala-Glu-Asn-Lys-NH2
    3 Publications Verification

    		 Amyloid-β Neurological Disease
    Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing .
    Fmoc-Ala-Glu-Asn-Lys-NH2
  • HY-148389
    Disialo-Asn

    Sialylglycoasparaginate

    		 Biochemical Assay Reagents Others
    Disialo-Asn (Sialylglycoasparaginate) is an asparagine oligosaccharide. Disialo-Asn can be used for nucleic acid modification .
    Disialo-Asn
  • HY-P11200
    γ-Glu-Asn

    γ-Glutamylasparagine

    		 Calcium Channel Neurological Disease
    γ-Glu-Asn (γ-Glutamylasparagine) is a calcium sensing receptor (CaSR) agonist. γ-Glu-Asn is a dipeptide composed of glutamic acid and asparagine .
    γ-Glu-Asn
  • HY-P3615
    [Asn18] Endothelin-1 (swine, human)

    		Endothelin Receptor Cardiovascular Disease
    [Asn18] Endothelin-1 swine, human is a structural analogue of Endothelin 1 (swine, human) (HY-P0202), with the Asp amino acid at position 18 mutated to Asn. Endothelin 1 (swine, human) is a synthetic peptide with human and porcine endothelin 1 sequences and is a potent endogenous vasoconstrictor .
    [Asn18] Endothelin-1 (swine, human)
  • HY-139147
    iHCK-37

    Asn05260065

    		 Src Infection Cancer
    iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research .
    iHCK-37
  • HY-P1962
    β-Secretase inhibitor

    [Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)

    		 Beta-secretase Neurological Disease
    β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase) .
    β-Secretase inhibitor
  • HY-136579A
    ASN007 benzenesulfonate
    5 Publications Verification

    ERK-IN-3 benzenesulfonate

    		 ERK Cancer
    ASN007 (ERK-IN-3) benzenesulfonate is a potent and orally active inhibitor of ERK. ASN007 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC50 values. ASN007 benzenesulfonate exhibits significant anti proliferative activity against various tumor cells. ASN007 benzenesulfonate can be used for the research of cancers driven by RAS mutations .
    ASN007 benzenesulfonate
  • HY-N0667R
    L-Asparagine (Standard)

    (-)-Asparagine (Standard); Asn (Standard); Asparamide (Standard)

    		 Reference Standards Endogenous Metabolite Apoptosis DNA/RNA Synthesis Inflammation/Immunology
    L-Asparagine (Standard) is the analytical standard of L-Asparagine (HY-N0667). This product is intended for research and analytical applications. L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
    L-Asparagine (Standard)
  • HY-P1043
    NGR peptide
    1 Publications Verification

    		 Aminopeptidase Cancer
    NGR peptide containing the Asn-Gly-Arg (NGR) motif. NGR peptide binds to APN/CD13. NGR peptide is directly conjugated to imaging agents that can be used for tumor imaging .
    NGR peptide
  • HY-131092A
    H-Asn-Arg-OH diTFA

    Asn-Arg diTFA

    		 Drug Intermediate Others
    H-Asn-Arg-OH diTFA is a dipeptide formed by the connection of asparagine and arginine via a peptide bond, which can be used in polypeptide synthesis.
    H-Asn-Arg-OH diTFA
  • HY-111323
    ASN06917370

    		ROR Neurological Disease
    ASN06917370 is a former orphan receptor GPR17 ligand for the study of neurodegenerative diseases. ASN06917370 has an EC50 of 268 pM in [35S]GTPyS experiments .
    ASN06917370
  • HY-113667
    ASN04885796

    		Transmembrane Glycoprotein Cardiovascular Disease Neurological Disease
    ASN04885796 (compound IV) is an GPR17 activator with an EC50 of 2.27 nM for GPR17 induced GTPγS binding. ASN04885796 has neuroprotective property and can be used for research of neurological diseases .
    ASN04885796
  • HY-W008233
    Z-Asn-OH

    		Amino Acid Derivatives Others
    Z-Asn-OH is an asparagine derivative .
    Z-Asn-OH
  • HY-148393
    G0 N-glycan-Asn

    		Biochemical Assay Reagents Others
    G0 N-glycan-Asn is a glycopeptide. G0 N-glycan-Asn can be used for various biochemical studies .
    G0 N-glycan-Asn
  • HY-P10485
    Glp-Asn-Pro-AMC

    		Thyroid Hormone Receptor Neurological Disease
    Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a Ki value of 0.97 μM .
    Glp-Asn-Pro-AMC
  • HY-129360
    Ala-Ala-Asn-PAB

    		ADC Linker Cancer
    Ala-Ala-Asn-PAB is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs) .
    Ala-Ala-Asn-PAB
  • HY-144628
    Fmoc-Asn-Pro-Val-PABC-PNP

    		ADC Linker Cancer
    Fmoc-Asn-Pro-Val-PABC-PNP (compound 6) is a potent ADC Linker .
    Fmoc-Asn-Pro-Val-PABC-PNP
  • HY-151829
    Fmoc-L-Asn(EDA-N3)-OH

    		ADC Linker Others
    Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Fmoc-L-Asn(EDA-N3)-OH
  • HY-N0667S3
    L-Asparagine-13C4 monohydrate

    (-)-Asparagine-13C4 monohydrate; Asn-13C4 monohydrate; Asparamide-13C4 monohydrate

    		 Isotope-Labeled Compounds Endogenous Metabolite Apoptosis DNA/RNA Synthesis Inflammation/Immunology
    L-Asparagine- 13C4 monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .
    L-Asparagine-13C4 monohydrate
  • HY-W010719
    Fmoc-D-Asn(Trt)-OH

    		Amino Acid Derivatives Others
    N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)-D-asparagine is an asparagine derivative .
    Fmoc-D-Asn(Trt)-OH
  • HY-P2929C
    PNGase F (Lyophilized)
    1 Publications Verification

    		 Glycosidase Cancer
    PNGase F (Lyophilized) is a glycosidase expressed by recombinant E. coli. PNGase F (Lyophilized) can selectively hydrolyze all N-glycans linked to Asn in proteins except those containing α1-3 fucosidic bonds. The cleavage site is the glycosidic bond between Asn and the innermost GIcNAc, which releases sugar molecules linked to asparagine from glycoproteins and converts asparagine to aspartic acid. The cleaved glycoforms include high mannose, hybrid and complex oligosaccharides .
    PNGase F (Lyophilized)
  • HY-156314
    ASN 07115873

    		Flavivirus Infection
    ASN 07115873 is an anti-ZIKV compound (IC50: 189.2 pM), and can be used for antiviral research .
    ASN 07115873
  • HY-113761
    ASN03576800

    		Filovirus Infection
    ASN03576800 could be a potent inhibitor for Ebola virus matrix protein VP40 in process of viral assembly and budding process. ASN03576800 occupies the RNA binding region of VP40 .
    ASN03576800
  • HY-128111
    ASN02563583

    		Transmembrane Glycoprotein Neurological Disease
    ASN02563583, a compound that regulates the activity of the GPR17 receptor, has a IC50 value of 0.64 nM in [35S]GTPγS binding assay. ASN02563583 can be used in the study of neurological diseases .
    ASN02563583
  • HY-P2212
    (Asn1,Val5)-Angiotensin II

    		Angiotensin Receptor Inflammation/Immunology
    Angiotensin amide ((Asn1,Val5)-Angiotensin II) is a potent vasoconstrictor. Angiotensin amide is a derivative of angiotensin II. Angiotensin amide can be used as a cardiac activator .
    (Asn1,Val5)-Angiotensin II
  • HY-129361
    Fmoc-Ala-Ala-Asn-PABC-PNP

    		ADC Linker Cancer
    Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker .
    Fmoc-Ala-Ala-Asn-PABC-PNP
  • HY-141464
    Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH

    Fmoc-Asn(Ac3AcNH-beta-Glc)-OH

    		 Amino Acid Derivatives Cancer
    Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH (Fmoc-Asn(Ac3AcNH-beta-Glc)-OH) can be used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, as tumor imaging agents, are useful tool for the research of positron emission tomography (PET) .
    Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH
  • HY-P4407
    (D-Asn28)-Exenatide

    		Glucocorticoid Receptor Metabolic Disease
    (D-Asn28)-Exenatide is an Exenatide (HY-13443) impurity. Exenatide is a long-acting glucagon-like peptide-1 receptor agonist .
    (D-Asn28)-Exenatide
  • HY-144629
    Asn-Pro-Val-PABC-MMAE TFA

    		Drug-Linker Conjugates for ADC Cancer
    Asn-Pro-Val-PABC-MMAE TFA (compound 8) is a potent ADC Linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Asn-Pro-Val-PABC-MMAE TFA
  • HY-144630
    diSPhMC-Asn-Pro-Val-PABC-MMAE

    		Drug-Linker Conjugates for ADC Cancer
    diSPhMC-Asn-Pro-Val-PABC-MMAE (compound 9) is a potent ADC Linker used in the synthesis of antibody-drug conjugates (ADCs) .
    diSPhMC-Asn-Pro-Val-PABC-MMAE
  • HY-W010378R
    D-Asparagine (Standard)

    H-D-Asn-OH (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    D-Asparagine (Standard) (H-D-Asn-OH (Standard)) is the analytical standard of D-Asparagine (HY-W010378). This product is intended for research and analytical applications. D-Asparagine (H-D-Asn-OH) is a competitive inhibitor of L-Asparagine hydrolysis with a Ki value of 0.24 mM. D-Asparagine is a source of nitrogen for yeast strains. D-Asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme.
    D-Asparagine (Standard)
  • HY-P1043A
    NGR peptide Trifluoroacetate
    1 Publications Verification

    		 Aminopeptidase Cancer
    NGR peptide Trifluoroacetatecontaining the Asn-Gly-Arg (NGR) motif. NGR peptide Trifluoroacetate binds to APN/CD13. NGR peptide Trifluoroacetate is directly conjugated to imaging agents that can be used for tumor imaging .
    NGR peptide Trifluoroacetate
  • HY-176977
    Exatecan-mpGly-Asn-Asn-(βAla)

    		Drug-Linker Conjugates for ADC Cancer
    Exatecan-mpGly-Asn-Asn-(βAla) (Compound 10b) is a conjugate of Exatecan (HY-13631) and a linker. Exatecan-mpGly-Asn-Asn-(βAla) can be used to synthesize ADCs, such as α-HER2_mpGlyAsnAsn(β-Ala)_Exatecan. Exatecan-mpGly-Asn-Asn-(βAla) can also be used in tumor research .
    Exatecan-mpGly-Asn-Asn-(βAla)
  • HY-P991497
    ASN-500

    		RSV Infection
    ASN-500 is a human monoclonal antibody (mAb) targeting F/Fusion glycoprotein F0. ASN-500 can be used in respiratory syncytial virus infection research .
    ASN-500
  • HY-139245
    MC-Ala-Ala-Asn-PAB

    		ADC Linker Cancer
    MC-Ala-Ala-Asn-PAB is a linker extracted from patent CN104147612A, page 14. MC-Ala-Ala-Asn-PAB can be used to synthesis the tumor microenvironment specific activated micromolecular targeted conjugate .
    MC-Ala-Ala-Asn-PAB
  • HY-103018A
    Gusacitinib hydrochloride

    Asn-002 hydrochloride

    		 JAK Syk Inflammation/Immunology Cancer
    Gusacitinib (ASN-002) hydrochloride is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib hydrochloride rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib hydrochloride can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma .
    Gusacitinib hydrochloride

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