![[D-Val22, Phe33] Big Endothelin-1 (16-38), human](https://file.medchemexpress.com/product_pic/hy-p3569.gif "Click to View [D-Val22, Phe33] Big Endothelin-1 (16-38), human Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
Big Endothelin-1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "Big Endothelin-1" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P4159
CAS No.: 133972-52-8
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1 Cited Publications
Cat. No.: HY-P4159A
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Cat. No.: HY-P2538
CAS No.: 120796-97-6
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Cat. No.: HY-P3733
CAS No.: 124932-61-2
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Cat. No.: HY-P4912
CAS No.: 2243219-82-9
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Cat. No.: HY-P3569
CAS No.: 1206769-73-4
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Cat. No.: HY-P2539
CAS No.: 120796-99-8
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Cat. No.: HY-P5130
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Cat. No.: HY-15402
CAS No.: 210891-04-6
Synonyms: BMS 207940
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Edonentan (BMS 207940) is an orally active, highly selective endothelin A receptor (ETA receptor) antagonist with a Ki value of 0.01 nM against human targets. Edonentan blocks the pressor response induced by Big Endothelin-1 in conscious normotensive rats and the pressor response induced by ET-1 in conscious normotensive cynomolgus monkeys. Edonentan can be used in research related to cardiovascular diseases .
Cat. No.: HY-P4159B
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Cat. No.: HY-15402D
CAS No.: 264609-13-4
Synonyms: BMS 207940 hydrate
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Edonentan hydrate (BMS 207940 hydrate) is an orally active, highly selective endothelin A receptor (ETA receptor) antagonist with a Ki value of 0.01 nM against human targets. Edonentan hydrate blocks the pressor response induced by Big Endothelin-1 in conscious normotensive rats and the pressor response induced by ET-1 in conscious normotensive cynomolgus monkeys. Edonentan hydrate can be used in research related to cardiovascular diseases .
Cat. No.: HY-18211
CAS No.: 849066-09-7
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CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats .
Cat. No.: HY-182561
CAS No.: 155485-56-6
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Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
