264609-13-4
264609-13-4
Chemical Structure
Edonentan hydrate
Synonym(s): BMS 207940 hydrate
- CAS No.: 264609-13-4
- Formula:C28H34N4O6S
- Molecular Weight:554.66
IUPAC Name: N-((2'-(N-(4,5-dimethylisoxazol-3-yl)sulfamoyl)-4-(oxazol-2-yl)-[1,1'-biphenyl]-2-yl)methyl)-N,3,3-trimethylbutanamide hydrate
InChIKey: VRUJTPHFVRXEPB-UHFFFAOYSA-N
SMILES: CC(C)(C)CC(N(CC1=CC(C2=NC=CO2)=CC=C1C3=CC=CC=C3S(=O)(NC4=NOC(C)=C4C)=O)C)=O.O
Biological Activity: Edonentan (BMS 207940) hydrate is a potent and selective antagonist of the endothelin A (ETA) receptor, with a Ki of 10 pM. In rats, Edonentan has superior (100%) oral bioavailbility[1].
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Edonentan hydrate | Edonentan (BMS 207940) hydrate is a potent and selective antagonist of the endothelin A (ETA) receptor, with a Ki of 10 pM. In rats, Edonentan has superior (100%) oral bioavailbility. | |||||||||||||||||||||
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References
- [1]. Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003 Jan 2;46(1):125-37. [Content Brief]
Keywords
