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D-dopachrome tautomerase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ERK (1) Macrophage migration inhibitory factor (MIF) (2) PROTACs (1)
By Research Areas:	Cancer (3)
Click Chemistry:	Azide (2)

Inhibitors & Agonists

Recombinant Proteins

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159086

RGB097	Macrophage migration inhibitory factor (MIF)	Cancer
RGB097 is a potent D-dopachrome tautomerase (D-DT) inhibitor with an IC₅₀ value of 0.5 µM. RGB097 has the potential for the research of cancer .

HY-159087

RGB110	PROTACs	Cancer
RGB110 (Compound 10d) is a PROTAC inhibitor for **D-dopachrome tautomerase with an IC₅₀ of 5.9 μM. RGB110 causes no degradation of D-DT**. (Pink: ligand for target protein (HY-159164); Black: linker (HY-W125017); Blue: ligand for E3 ligase CRBN (HY-10984))

HY-181912

D-DT/MIF-1-IN-1	Macrophage migration inhibitory factor (MIF) ERK	Cancer
D-DT/MIF-1-IN-1 (Compound 4h) is a non-competitive, non-covalent inhibitor of MIF-1 and D-DT, with IC₅₀ values of 2.4 μM and 4.0 μM against D-DT, and an IC₅₀ value of 9.8 μM against MIF-1. D-DT/MIF-1-IN-1 inhibits D-DT-induced phosphorylation of ERK and exerts antiproliferative activity in non-small cell lung cancer cells .

Species:	Human (1) Mouse (1) Cynomolgus (1)
Tag:	His (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703833

	DDT Protein, Mouse (His) D-dopachrome decarboxylase; D-dopachrome tautomerase; Ddt;	Mouse	E. coli
	DDT Protein, Mouse (His) is the recombinant mouse-derived DDT protein, expressed by E. coli, with N-His tag.

HY-P703834

	DDT Protein, Human (His) D-dopachrome decarboxylase; D-dopachrome tautomerase; Phenylpyruvate tautomerase II; DDT;	Human	E. coli
	DDT Protein, Human (His) is the recombinant human-derived DDT protein, expressed by E. coli, with N-His tag.

HY-P703783

	DDT Protein, Cynomolgus (His) D-DT; D-dopachrome decarboxylase; D-dopachrome tautomerase; Phenylpyruvate tautomerase II; EC 4.1.1.84; MIF2; DDCT	Cynomolgus	E. coli
	DDT Protein, Cynomolgus (His) is the recombinant cynomolgus-derived DDT protein, expressed by E. coli, with N-His tag.

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Cat. No.	Product Name		Classification

HY-159086

RGB097		Azide
RGB097 is a potent D-dopachrome tautomerase (D-DT) inhibitor with an IC₅₀ value of 0.5 µM. RGB097 has the potential for the research of cancer .

HY-159087

RGB110		Azide
RGB110 (Compound 10d) is a PROTAC inhibitor for **D-dopachrome tautomerase with an IC₅₀ of 5.9 μM. RGB110 causes no degradation of D-DT**. (Pink: ligand for target protein (HY-159164); Black: linker (HY-W125017); Blue: ligand for E3 ligase CRBN (HY-10984))

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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