![4-[(1E)-2-Nitroethenyl]benzoic acid](https://file.medchemexpress.com/product_pic/hy-203082.gif "Click to View 4-[(1E)-2-Nitroethenyl]benzoic acid Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
E2 ligase
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "E2 ligase" in MCE Product Catalog:
1
Target:
Research Areas:
NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer .
1
1 Cited Publications
Cat. No.: HY-P79451
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin‑Conjugating Enzyme E2 L3; E2 Ubiquitin‑Conjugating Enzyme L3; Ubiquitin‑Conjugating Enzyme E2‑F1; Ubiquitin Carrier Protein L3; Ubiquitin‑Protein ligase L3; L‑UBC; Ubiquitin‑Conjugating Enzyme E
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P71398
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2B; RAD6B; UBCH1; Ubiquitin-conjugating enzyme E2 B; EC 2.3.2.23; E2 ubiquitin-conjugating enzyme B; RAD6 homolog B; HR6B; hHR6B; Ubiquitin carrier protein B; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase B
Species:
Human
Source:
HEK293
Cat. No.: HY-49444
CAS No.: 793719-01-4
Target:
Research Areas:
EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism .
Cat. No.: HY-159728
Research Areas:
PROTAC PRMT3 degrader 1 is a selective PRMT3 PROTAC degrader with a DC50 of 2.566 μM. PROTAC PRMT3 degrader 1 forms a ternary complex with MDM2 E3 ubiquitin ligase to induce proteasomal and neddylation-dependent degradation of PRMT3. PROTAC PRMT3 degrader 1 activates intrinsic apoptosis, endoplasmic reticulum stress signaling pathways. PROTAC PRMT3 degrader 1 downregulates E2F, MYC, oxidative phosphorylation pathways. PROTAC PRMT3 degrader 1 reduces cellular asymmetric dimethylarginine (ADMA) levels. PROTAC PRMT3 degrader 1 inhibits acute leukemia cell growth. PROTAC PRMT3 degrader 1 acts with glycolysis inhibitor 2-DG to reduce ATP production, induce intrinsic apoptosis, drive synergistic antiproliferative effects. PROTAC PRMT3 degrader 1 can be used for the research of acute leukemia .
Cat. No.: HY-170820
CAS No.: 3006788-11-7
Research Areas:
XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC50 of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, TMPRSS2, AR, AR-V7, PSA and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .
Cat. No.: HY-P77272
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2W; Ubiquitin Conjugating Enzyme E2 W; N‑Terminal E2 Ubiquitin‑Conjugating Enzyme; E2 Ubiquitin‑Conjugating Enzyme W; Ubiquitin Carrier Protein W; Ubiquitin‑Protein ligase W; N‑Terminus‑Conjugating E2; UBC‑16; Ubiquitin‑Conjugating Enzyme E2 W; Ubiquit
Species:
Human
Source:
E. coli
Cat. No.: HY-203082
CAS No.: 821797-33-5
Target:
Research Areas:
4-[(1E)-2-Nitroethenyl]benzoic acid is an E3 ligase ligand. 4-[(1E)-2-Nitroethenyl]benzoic acid can be used for synthesis of PROTAC BRD4 Degrader-38 (HY-175240) .
Cat. No.: HY-P71412
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2Z; Ubiquitin Conjugating Enzyme E2 Z; Ubiquitin‑Conjugating Enzyme E2 Z; E2 Ubiquitin‑Conjugating Enzyme Z; Ubiquitin Carrier Protein Z; Ubiquitin‑Protein ligase Z; USE1; Uba6‑Specific E2 Conjugating Enzyme 1; UBA6‑Specific Enzyme E2; FLJ13855; Ubiqui
Species:
Human
Source:
E. coli
Cat. No.: HY-P71402
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2H; Ubiquitin Conjugating Enzyme E2 H; (E3‑Independent) E2 Ubiquitin‑Conjugating Enzyme H; Ubiquitin‑Conjugating Enzyme E2‑20K; Ubiquitin‑Conjugating Enzyme E2 H; E2 Ubiquitin‑Conjugating Enzyme H; Ubiquitin Carrier Protein H; Ubiquitin‑Protein ligase
Species:
Human
Source:
E. coli
Cat. No.: HY-P701350
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: UBE2C; Ubiquitin Conjugating Enzyme E2 C; UBCH10; (E3-Independent) E2 Ubiquitin-Conjugating Enzyme C; Ubiquitin-Conjugating Enzyme E2 C; E2 Ubiquitin-Conjugating Enzyme C; Ubiquitin-Protein ligase C; Ubiquitin Carrier Protein C; Ubiquitin-Conjugating Enzy
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701494
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: UBE2O; Ubiquitin Conjugating Enzyme E2 O; (E3‑Independent) E2 Ubiquitin‑Conjugating Enzyme; E2/E3 Hybrid Ubiquitin‑Protein ligase UBE2O; Ubiquitin‑Conjugating Enzyme E2 Of 230 KDa; Ubiquitin Carrier Protein O; Ubiquitin‑Protein ligase O; E2‑230K; Ubiquiti
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71408
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2S; Ubiquitin Conjugating Enzyme E2 S; E2‑EPF; Ubiquitin‑Conjugating Enzyme E2‑24 KDa; Ubiquitin‑Conjugating Enzyme E2‑EPF5; Ubiquitin‑Conjugating Enzyme E2 S; E2 Ubiquitin‑Conjugating Enzyme S; Ubiquitin Carrier Protein S; Ubiquitin‑Protein ligase S;
Species:
Human
Source:
E. coli
Cat. No.: HY-P701493
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: UBE2O; Ubiquitin Conjugating Enzyme E2 O; (E3‑Independent) E2 Ubiquitin‑Conjugating Enzyme; E2/E3 Hybrid Ubiquitin‑Protein ligase UBE2O; Ubiquitin‑Conjugating Enzyme E2 Of 230 KDa; Ubiquitin Carrier Protein O; Ubiquitin‑Protein ligase O; E2‑230K; Ubiquiti
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71409
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2T; Ubiquitin Conjugating Enzyme E2 T; Ubiquitin‑Conjugating Enzyme E2 T; E2 Ubiquitin‑Conjugating Enzyme T; Ubiquitin Carrier Protein T; Ubiquitin‑Protein ligase T; HSPC150; FANCT; Cell Proliferation‑Inducing Gene 50 Protein; Ubiquitin‑Conjugating Enz
Species:
Human
Source:
E. coli
Cat. No.: HY-P71400
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2D4; Ubiquitin Conjugating Enzyme E2 D4; HBUCE1; Ubiquitin‑Conjugating Enzyme E2 D4; E2 Ubiquitin‑Conjugating Enzyme D4; Ubiquitin Carrier Protein D4; Ubiquitin‑Protein ligase D4; Ubiquitin‑Conjugating Enzyme E2D 4 (Putative); Ubiquitin Conjugating Enz
Species:
Human
Source:
E. coli
Cat. No.: HY-P703297
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin‑Conjugating Enzyme E2 L3; E2 Ubiquitin‑Conjugating Enzyme L3; Ubiquitin‑Conjugating Enzyme E2‑F1; Ubiquitin Carrier Protein L3; Ubiquitin‑Protein ligase L3; L‑UBC; Ubiquitin‑Conjugating Enzyme E
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P71397
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2A; Ubiquitin Conjugating Enzyme E2 A; HHR6A; RAD6A; UBC2; HR6A; Ubiquitin‑Conjugating Enzyme E2 A; E2 Ubiquitin‑Conjugating Enzyme A; Ubiquitin‑Conjugating Enzyme E2A; Ubiquitin Carrier Protein A; Ubiquitin‑Protein ligase A; RAD6 Homolog A; Ubiquitin‑
Species:
Human
Source:
E. coli
Cat. No.: HY-P703298
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L3; Ubiquitin Conjugating Enzyme E2 L3; UBCH7; Ubiquitin‑Conjugating Enzyme E2 L3; E2 Ubiquitin‑Conjugating Enzyme L3; Ubiquitin‑Conjugating Enzyme E2‑F1; Ubiquitin Carrier Protein L3; Ubiquitin‑Protein ligase L3; L‑UBC; Ubiquitin‑Conjugating Enzyme E
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P702064
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2L5; Ubiquitin Conjugating Enzyme E2 L5; UBE2L5P; Ubiquitin‑Conjugating Enzyme E2 L5; Ubiquitin‑Protein ligase L5; Ubiquitin Conjugating Enzyme E2L 5 (Pseudogene); Ubiquitin Conjugating Enzyme E2 L5, Pseudogene; UBCH7N2
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
