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Results for "

Erk5 kinase inhibitor

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108886
    JWG-071
    5 Publications Verification

    		 ERK Cancer
    JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively .
    JWG-071
  • HY-112082
    BAY885
    1 Publications Verification

    		 ERK Cancer
    BAY885, a chemical probe, is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases .
    BAY885
  • HY-156450
    ERK5-IN-5

    		ERK Cancer
    ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-5 exhibits good anti-proliferative activity with the IC50 value of 6.23 µg/mL for A549 cells .
    ERK5-IN-5
  • HY-156451
    ERK5-IN-6

    		ERK Cancer
    ERK5-IN-6 (compound 5J) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-6 exhibits good anti-proliferative activity with the IC50 value of 4.56 µg/mL for A549 cells .
    ERK5-IN-6
  • HY-150606
    ERK5-IN-4

    		ERK Cancer
    ERK5-IN-4 (compound 34b) is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). ERK5-IN-4 inhibits ERK5 (full-length) and truncated ERK5 (ERK5 ΔTAD) kinase activity in HEK293 cells with an IC50 of 77 nM and 300 nM, respectively .
    ERK5-IN-4
  • HY-150605
    ERK5-IN-3

    		ERK Cancer
    ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM .
    ERK5-IN-3
  • HY-181477
    ERK5-IN-7

    		ERK Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species (ROS) Cancer
    ERK5-IN-7 is an orally active ERK5 inhibitor with an IC50 of 403.4 nM. ERK5-IN-7 directly inhibits ERK5 kinase activity, and downregulates the phosphorylation level and total protein expression of ERK5. ERK5-IN-7 induces Apoptosis (upregulates Bax, downregulates Bcl-2, and induces Caspase-3 cleavage). ERK5-IN-7 induces ROS accumulation. ERK5-IN-7 exhibits anticancer effects against Lewis lung cancer .
    ERK5-IN-7
  • HY-108886R
    JWG-071 (Standard)

    		Reference Standards ERK Cancer
    JWG-071 (Standard) is the analytical standard of JWG-071 (HY-108886). This product is intended for research and analytical applications. JWG-071 is the Kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively .
    JWG-071 (Standard)

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