29 Results for "

F(ab')2

" in MedChemExpress (MCE) Product Catalog:
Products (29)

29 Results for "F(ab')2" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P99507
CAS No.: 1969309-56-5
Synonyms: MCLA-128; PB4188; R040517

Target:  

EGFR

Research Areas:  

Cancer

Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3 .
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2
2 Cited Publications
Cat. No.: HY-P99644
CAS No.: 2101829-58-5

Target:  

Glycoprotein VI

Research Areas:  

Cardiovascular Disease

ACT017 is a Fab fragment of humanized anti-GPVI monoclonal antibody. ACT017 inhibits collagen-induced platelet aggregation. ACT017 has the potential for the research of acute ischemic stroke [2].
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1
1 Cited Publications
Cat. No.: HY-NP006
CAS No.: 308083-69-4
Synonyms: SPA
Protein A (SPA) is an immunoglobulin (Ig)-binding protein that exists on the bacterial surface and can be freely secreted into the extracellular environment. Protein A blocks opsonophagocytosis and induces B cell apoptosis in vitro by binding to the Fc region of antibodies and the Fab region of B cell receptors. Protein A can form toxic immune complexes with IgG, thereby inducing leukocyte necrosis. Protein A contributes to the virulence expression of Staphylococcus aureus. Protein A triggers allergic reactions in IgG-pretreated mouse models. Protein A can be used in studies related to immune system diseases [2] .
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1
1 Cited Publications
Cat. No.: HY-E70365A
Research Areas:  

Inflammation/Immunology

IdeS (Immobilized, Microspin) is a resin that covalently couples IdeS protease to agarose beads and cleaves IgG at specific sites to generate F(ab')2 and Fc fragments. After IdeS (Immobilized, Microspin) digestion, F(ab')2 and Fc fragments are obtained in the solution without IdeS enzyme.
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Cat. No.: HY-P990688
CAS No.: 2559056-68-5
Synonyms: AMG-509

Target:  

CD3

Research Areas:  

Cancer

Xaluritamig (AMG-509) is a bispecific T cell engager and cytolytic agent with a Kd of 27.6 nM for human CD3ε. Xaluritamig binds to CD3ε via an anti-CD3 single-chain variable fragment (scFv) domain, and to STEAP1 via a bispecific anti-STEAP1 antigen-binding fragment (Fab) domain, thereby recruiting and activating T cells and forming a bridge between T cells and STEAP1-expressing cancer cells. Xaluritamig induces T cell-mediated redirected cytotoxicity, tumor cell lysis, cytokine release, CD8 + T cell activation and expansion, as well as tumor stasis or regression. Xaluritamig contains an Fc domain with no effector function, which prolongs serum half-life, exhibits only minimal activity against cells with low STEAP1 expression and normal cells, and shows extremely low target-related off-tumor toxicity in cynomolgus monkeys. Xaluritamig is used in STEAP1×CD3 XmAb 2+1 immunotherapy and in research on metastatic castration-resistant prostate cancer and Ewing sarcoma [2] .
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Cat. No.: HY-P990735
CAS No.: 2765066-99-5
Synonyms: UCB-1381

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Donzakimig is a trispecific anti-IL-13/IL-22/HSA antibody. Donzakimig adopts a Fab-scFv-scFv structural format (without an Fc region), in which the Fab domain is linked to the scFv domains via a S (G4S)2 linker. Donzakimig binds to and inhibits the activities of IL-13 and IL-22, thereby blocking the signal transduction of these two cytokines. Donzakimig can extend its serum half-life by binding to human serum albumin, enhancing its in vivo stability and achieving long-acting efficacy. Donzakimig can be used in research on moderate-to-severe atopic dermatitis, moderate-to-severe asthma (especially eosinophilic type), psoriasis, inflammatory bowel disease, and other conditions .
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Cat. No.: HY-P99629
CAS No.: 2403683-24-7
Synonyms: FHTR 2163; RG 6147; RO 7171009

Target:  

Ser/Thr Protease

Research Areas:  

Neurological Disease

Galegenimab (FHTR 2163) is a humanized monoclonal antibody Fab fragment targeting the HtrA1 trimer. Galegenimab is used in research on age-related macular degeneration (AMD) [2].
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Cat. No.: HY-P990981
CAS No.: 2930861-48-4
Synonyms: ALPS-12; RG-6524; RO 7616789

Target:  

CD3

Research Areas:  

Inflammation/Immunology Cancer

Clesitamig (ALPS-12) is a trispecific T cell engager with two CD3/CD137 dual-specific Fabs and one DLL3 Fab. Clesitamig engages CD3 and CD137 on T cells to activate and co-stimulate T cells, promoting their proliferation, survival, and antitumor activity. Clesitamig binds to DLL3 on tumor cells for tumor-specific recognition. Clesitamig can be used for the research of small cell lung cancer (SCLC) [2].
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Cat. No.: HY-P99155
CAS No.: 667901-13-5
Synonyms: 2F8; HUMAX-EGFR

Target:  

EGFR

Research Areas:  

Cancer

Zalutumumab is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab can be used for the research of cancer [2] .
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Cat. No.: HY-P99872
CAS No.: 2415207-91-7
Synonyms: CSJ-117; NVP-CSJ117

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ecleralimab (CSJ-117; NVP-CSJ117) is a Fab-IgG1-λ2 antibody targeting the thymic stromal lymphopoietin (TSLP). Ecleralimab significantly attenuates allergen-induced airway responses and inflammation. Ecleralimab can be used for the study of inhaled asthma .
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Cat. No.: HY-D0054
CAS No.: 142978-18-5
Target:  

Fluorescent Dye

Research Areas:  

Inflammation/Immunology

9-(2-Carboxy-2-cyanovinyl)julolidine is a fluorescent molecular rotor. 9-(2-Carboxy-2-cyanovinyl)julolidine can be used to bind to IgG and Fab, and preparing antibodies .
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Cat. No.: HY-131763
CAS No.: 55443-13-5
Purity:  99.94%
Synonyms: 2'-O-Monobutyryl cyclic AMP sodium
Research Areas:  

Cancer

2'-O-MB-cAMP (2'-O-Monobutyryl cyclic AMP) sodium is an inactive analog of Cyclic AMP. 2'-O-MB-cAMP sodium serves as a reference standard in FAB/MIKE mass spectrometry for the characterization of butyryl derivatives of cyclic nucleotides. 2'-O-MB-cAMP sodium does not induce differentiation or upregulate Nm23-R1 in glioma cells. 2'-O-MB-cAMP sodium can be used as a negative control cAMP analog for glioma-related research [2] .
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Cat. No.: HY-E70364
CAS No.: 1892548-76-3
Research Areas:  

Inflammation/Immunology

IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .
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Cat. No.: HY-P11009
Target:  

Inhibitory Antibodies

Research Areas:  

Others

SA-21 is a 21-amino acid polymer peptide (Ac-RLIEDICLPRWGCLWEDD-NH2) that binds to ligands of urokinase-type plasminogen activator, Fab antibody fragments, and small proteins. SA-21 can be used to purify albumin (Ki=1.9 μM) .
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Cat. No.: HY-P99155A
CAS No.: 667901-13-5

Target:  

EGFR

Research Areas:  

Cancer

Zalutumumab (powder) is a high affinity, completely human IgG1 monoclonal antibody targeting EGFR. Zalutumumab (powder) binds to domain III of the EGF receptor and acts by blocking the binding of EGF and by sterically interfering with the active conformation of the receptor. Zalutumumab (powder) binds with IgG and its Fab fragment with EC50s of 7 and 19 nM, respectively. Zalutumumab (powder) can be used for the research of cancer [2] .
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Cat. No.: HY-P990005

Target:  

Inhibitory Antibodies

Research Areas:  

Others

Mouse IgG2a Fc, Isotype Control, is a Fc fragment of mouse IgG2a only and does not contain the Fab fragments. The molecular mass is about 52 kDa.
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Cat. No.: HY-P991037
CAS No.: 2699034-69-8
Synonyms: GNR 055

Target:  

Steroid Sulfatase

Research Areas:  

Metabolic Disease

Verenafusp alfa (GNR 055) is a recombinant fusion protein of iduronate-2-sulfatase and a monoclonal antibody Fab fragment to human insulin receptor for distribution of the enzyme into brain. Verenafusp alfa can be used for the study of mucopolysaccharidosis type II (MPS II) .
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Cat. No.: HY-P991738
Target:  

PD-1/PD-L1 VEGFR

Research Areas:  

Cancer

LM-299 is a bispecific antibody targeting PD-1 and VEGF with anti-tumor activity. The dual binding activity of LM-299 is achieved through the effective binding of its Fab-terminal anti-VEGF-A antibody to human VEGF-A, as well as the blocking effect of its Fc-terminal anti-PD-1 antibody on the PD-1/PD-L1 pathway. LM-299 binds to and modulates PD-1 and VEGF. LM-299 can be used in studies related to advanced malignant tumors, advanced solid tumors, and advanced non-small cell lung cancer [2].
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Cat. No.: HY-P991594

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-IL-13 Antibody (C836) is a neutralizing monoclonal antibody targeting human IL-13. The Fab fragment of Anti-IL-13 Antibody (C836) is a heterodimer composed of heavy chains and light chains, each folded into variable and constant domains. Anti-IL-13 Antibody (C836) can be used for chronic inflammatory diseases, such as asthma [2] .
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Cat. No.: HY-P99803
CAS No.: 2145123-44-8
Synonyms: VAL-1221

Target:  

Glycosidase

Research Areas:  

Others

Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research .
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