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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
G-protein α subunit
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "G-protein α subunit" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P5985
CAS No.: 593267-11-9
Cat. No.: HY-W013706
CAS No.: 35908-31-7
Synonyms: ITP trisodium salt; Inosine triphosphate trisodium salt
Target:
Cat. No.: HY-171978A
Target:
Research Areas:
LM-189 free base, a G protein alpha subunit I (Gαi)-biased agonist, is a Gαi-biased ligand of β2-adrenergic receptor (β2AR). LM-189 free base stabilizes a distinct conformation in TM6 and increases the dynamics of ICL2. LM-189 free base can be used to develop the Gαi-biased β2AR agonists .
Cat. No.: HY-W041308
CAS No.: 64359-81-5
Synonyms: Kathon 930
Research Areas:
DCOIT (Kathon 930) is an isothiazolinone biocide and environmental pollutant that directly binds to G protein α subunits, with KD values of 0.92 mM and 0.4 mM for Gαs and Gαi, respectively. Binding of DCOIT to Gαi enhances the interaction between Gαi and mitochondrial calcium uniporter (MCU), alters the subcellular distribution of intracellular Ca 2+, and activates PKC/MEK/ERK signaling. DCOIT upregulates CYP19a transcription and aromatase activity, thereby disrupting steroid hormone homeostasis. DCOIT is used in studies of reproductive endocrine disruption and environmental toxicology .
Cat. No.: HY-W041308R
CAS No.: 64359-81-5
Synonyms: Kathon 930 (Standard)
Research Areas:
DCOIT (Standard) (Kathon 930 (Standard)) is the analytical standard of DCOIT (HY-W041308). This product is intended for research and analytical applications. DCOIT (Kathon 930) is an isothiazolinone biocide and environmental pollutant that directly binds to G protein α subunits, with KD values of 0.92 mM and 0.4 mM for Gαs and Gαi, respectively. Binding of DCOIT to Gαi enhances the interaction between Gαi and mitochondrial calcium uniporter (MCU), alters the subcellular distribution of intracellular Ca 2+, and activates PKC/MEK/ERK signaling. DCOIT upregulates CYP19a transcription and aromatase activity, thereby disrupting steroid hormone homeostasis. DCOIT is used in studies of reproductive endocrine disruption and environmental toxicology .
Cat. No.: HY-W686762
CAS No.: 219704-16-2
Target:
Research Areas:
m,p-Dimethyl PPE is a D4 dopamine receptor ligand. m,p-Dimethyl PPE promotes GDP/GTP exchange of the G protein α-subunit, dissociates the receptor-G protein complex, stabilizes the low-affinity receptor state, and inhibits adenylate cyclase activity. m,p-Dimethyl PPE inhibits Forskolin (HY-15371)-induced melatonin synthesis in retinal photoreceptor cells and reduces the efficacy of full agonists when used in combination. m,p-Dimethyl PPE can be used in studies related to attention-deficit hyperactivity disorder .
Cat. No.: HY-P72207
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GNAO1; GO2-Q Chimeric G-protein; G protein subunit Alpha O1; EIEE17; Guanine Nucleotide-Binding protein G(O) subunit Alpha; DEE17; G-ALPHA-O; NEDIM; Guanine Nucleotide Binding protein (G protein), Alpha Activating Activity Polypeptide O; GNAO; Heterotrime
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P703004
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: GNA14; Heterotrimeric Guanine Nucleotide-Binding protein 1I; G protein subunit Alpha 14; Guanine Nucleotide-Binding protein 14; Guanine Nucleotide Binding protein (G protein), Alpha 14; G-protein subunit Alpha-14; Guanine Nucleotide-Binding protein Subuni
Species:
Human
Source:
E. coli
Cat. No.: HY-150172A
CAS No.: 3056945-75-3
Synonyms: ITP lithium salt; Inosine triphosphate lithium salt
Target:
Research Areas:
Inosine-5'-triphosphate (ITP) lithium salt is a nucleotide analogue that acts on multiple G proteins. Inosine-5'-triphosphate lithium salt can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Inosine-5'-triphosphate lithium salt interacts with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. Inosine-5'-triphosphate lithium salt is used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes .
Cat. No.: HY-W013706R
CAS No.: 35908-31-7
Synonyms: ITP trisodium salt (Standard); Inosine triphosphate trisodium salt (Standard)
Cat. No.: HY-P72208
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GNAZ; Guanine Nucleotide Binding protein (G protein), Alpha Z Polypeptide; G protein subunit Alpha Z; Heterotrimeric Guanine Nucleotide-Binding protein 1H; Guanine Nucleotide-Binding protein G(Z) subunit Alpha; Transducin Alpha; G(X) Alpha Chain; HG1H; Gz
Species:
Human
Source:
E. coli
Cat. No.: HY-P86889
Synonyms: Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; Adenylate cyclase stimulating G alpha protein antibody; AHO antibody; Alternative gene product encoded by XL exon antibody; C20orf45 antibody; dJ309F20.1.1 antibody; dJ806M20.3.3 antibody; Extra large alphas protein antibody; GNAS antibody; GNAS complex locus antibody; GNAS1 antibody; GPSA antibody; Gs alpha subunit antibody; GSA antibody; GSP antibody; Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein alpha stimulating activity polypeptide 1 antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms short antibody; Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas antibody; Guanine nucleotide regulatory protein antibody; MGC33735 antibody; NESP antibody; NESP55 antibody; Neuroendocrine secretory protein antibody; PHP1A antibody; PHP1B antibody; PHP1C antibody; POH antibody; protein ALEX antibody; protein GNAS antibody; protein NESP55 antibody; SCG6 antibody; Secretogranin VI antibody; XLalphas antibody; XLas antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
