3056945-75-3
Chemical Structure
Inosine 5'-triphosphate lithium salt
Synonym(s): ITP lithium salt; Inosine triphosphate lithium salt
- CAS No.: 3056945-75-3
- Formula:C10H11Li4N4O14P3
- Molecular Weight:531.90
InChIKey: OBNQCEJMUGCRFL-KWIZKVQNSA-J
SMILES: O=C1N=CNC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)[C@@H](O)[C@H]3O
Biological Activity: Inosine-5'-triphosphate (ITP) lithium salt is a nucleotide analogue that acts on multiple G proteins. Inosine-5'-triphosphate lithium salt can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Inosine-5'-triphosphate lithium salt interacts with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. Inosine-5'-triphosphate lithium salt is used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes[1][2][3][4].
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Inosine 5'-triphosphate lithium salt | Inosine-5'-triphosphate (ITP) lithium salt is a nucleotide analogue that acts on multiple G proteins. Inosine-5'-triphosphate lithium salt can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Inosine-5'-triphosphate lithium salt interacts with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. Inosine-5'-triphosphate lithium salt is used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes. | |||||||||||||||||||||
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References
- [1]. Hanson RL, et al. Energy-transducing adenosine triphosphatase from Escherichia coli: purification, properties, and inhibition by antibody. J Bacteriol. 1973 May;114(2):772-81. [Content Brief]
- [2]. Pieper U, et al. The GTP-binding domain of McrB: more than just a variation on a common theme? J Mol Biol. 1999 Sep 24;292(3):547-56. [Content Brief]
- [3]. Klinker JF, et al. Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes. Biochem Pharmacol. 1997 Sep 1;54(5):551-62.
- [4]. Burnstock G, et al. Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol. 1972 Mar;44(3):451-61. [Content Brief]
