GABA-transaminase

By Targets:	Endogenous Metabolite (3) GABA Receptor (18) Histone Demethylase (2) HIV (2) Influenza Virus (1) Isotope-Labeled Compounds (3) Monoamine Oxidase (2) Reference Standards (4)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (17)
Click Chemistry:	Alkynes (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15399

Vigabatrin Maximum Cited Publications 6 Publications Verification γ-Vinyl-GABA	GABA Receptor	Neurological Disease
Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible *GABA transaminase* inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by *GABA transaminase* .

HY-B1122

L-Cycloserine 2 Publications Verification (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	GABA Receptor HIV	Neurological Disease Cancer
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .

HY-B1018A

Phenelzine sulfate Maximum Cited Publications 6 Publications Verification	Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits *GABA transaminase* and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-B0033

Vigabatrin hydrochloride Maximum Cited Publications 6 Publications Verification γ-Vinyl-GABA hydrochloride	GABA Receptor	Neurological Disease
Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible *GABA transaminase* inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by *GABA transaminase* .

HY-101414

L-DABA 1 Publications Verification L-2,4-Diaminobutyric acid	GABA Receptor Endogenous Metabolite	Neurological Disease Cancer
L-DABA (L-2,4-Diaminobutyric acid) is a week *GABA* transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-131693A

*γ-Acetylenic GABA* hydrochloride** GAG hydrochloride	GABA Receptor	Neurological Disease Cancer
γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of *GABA-transaminase. γ-Acetylenic GABA* hydrochloride can increase the concentration of GABA in rat brain . γ-Acetylenic GABA (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W012738

DL-Pyroglutamic acid 1 Publications Verification	Influenza Virus GABA Receptor	Infection
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of *GABA* transaminase, increases GABA amount with antiepileptic action .

HY-N15001

Gabaculine	GABA Receptor	Neurological Disease
Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable *GABA* transaminase inhibitor, with an IC₅₀ of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders .

HY-116910

CPP-115	GABA Receptor	Neurological Disease
CPP-115 is a *GABA transaminase* inactivator with higher affinity and lower retinal toxicity than Vigabatrin (HY-15399). CPP-115 increases brain GABA levels by inhibiting *GABA transaminase* catabolism. CPP-115 can be used in the study of drug addiction and infantile spasms .

HY-B1018AS

Phenelzine-d5 sulfate	Isotope-Labeled Compounds Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits *GABA transaminase* and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-131693

γ-Acetylenic GABA GAG	GABA Receptor	Neurological Disease Cancer
γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of *GABA-transaminase. γ-Acetylenic GABA* can increase the concentration of GABA in rat brain . γ-Acetylenic GABA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0033S

Vigabatrin-13C,d2 hydrochloride γ-Vinyl-GABA-13C,d2 hydrochloride	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-101414A

L-DABA hydrobromide 1 Publications Verification L-2,4-Diaminobutyric acid hydrobromide	Endogenous Metabolite GABA Receptor	Neurological Disease Cancer
L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week *GABA* transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-15399R

Vigabatrin (Standard) γ-Vinyl-GABA (Standard)	Reference Standards GABA Receptor	Neurological Disease
Vigabatrin (Standard) is the analytical standard of Vigabatrin. This product is intended for research and analytical applications. Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-W778008

Rac-Vigabatrin-13C,d2 (Major)	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
Rac-Vigabatrin- ¹³C,d₂ (Major) is the deuterium and ¹³C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-101414R

L-DABA (Standard) L-2,4-Diaminobutyric acid (Standard)	Reference Standards GABA Receptor Endogenous Metabolite	Neurological Disease Cancer
L-DABA (Standard) is the analytical standard of L-DABA. This product is intended for research and analytical applications. L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-B1122R

L-Cycloserine (Standard) (S)-Cycloserine (Standard); (S)-4-Amino-3-isoxazolidone (Standard)	Reference Standards GABA Receptor HIV	Neurological Disease Cancer
L-Cycloserine (Standard) is the analytical standard of L-Cycloserine. This product is intended for research and analytical applications. L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].

HY-B0033R

Vigabatrin hydrochloride (Standard) γ-Vinyl-GABA hydrochloride (Standard)	GABA Receptor Reference Standards	Neurological Disease
Vigabatrin (hydrochloride) (Standard) is the analytical standard of Vigabatrin (hydrochloride). This product is intended for research and analytical applications. Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1122

L-Cycloserine 2 Publications Verification (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	GABA Receptor HIV
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .

HY-101414

L-DABA 1 Publications Verification L-2,4-Diaminobutyric acid	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	GABA Receptor Endogenous Metabolite
L-DABA (L-2,4-Diaminobutyric acid) is a week *GABA* transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-N15001

Gabaculine	Structural Classification Natural Products Microorganisms Source Classification	GABA Receptor
Gabaculine is an amino acid neurotoxin and blood-brain barrier-permeable *GABA* transaminase inhibitor, with an IC₅₀ of 1 μM in beef and Pseudomonas ovalis. Gabaculine elevates endogenous synaptic and brain GABA levels and enhances GABA activity. Gabaculine induces sedation, hypothermia, loss of righting reflex, and prevents convulsions in mice. Gabaculine is applicable to research related to neurological disorders .

HY-101414A

L-DABA hydrobromide 1 Publications Verification L-2,4-Diaminobutyric acid hydrobromide	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite GABA Receptor
L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week *GABA* transaminase inhibitor with an IC₅₀ of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-101414R

L-DABA (Standard) L-2,4-Diaminobutyric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards GABA Receptor Endogenous Metabolite
L-DABA (Standard) is the analytical standard of L-DABA. This product is intended for research and analytical applications. L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

HY-B1122R

L-Cycloserine (Standard) (S)-Cycloserine (Standard); (S)-4-Amino-3-isoxazolidone (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards GABA Receptor HIV
L-Cycloserine (Standard) is the analytical standard of L-Cycloserine. This product is intended for research and analytical applications. L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72068

	ABAT Protein, Human (His, SUMO, Myc) S; 3 amino 2 methylpropionate transaminase ; S; -3-amino-2-methylpropionate transaminase; 4 aminobutyrate aminotransferase; 4 aminobutyrate aminotransferase; mitochondrial; 4-aminobutyrate aminotransferase; ABAT; FLJ17813; FLJ30272; GABA aminotransferase; GABA AT; GABA T; GABA transaminase; GABA transferase; GABA-AT; GABA-T; GABAT; GABT_HUMAN; Gamma amino N butyrate transaminase; Gamma-amino-N-butyrate transaminase; hCG1984265; L AIBAT; L-AIBAT; LAIBAT; mitochondrial; NPD009	Human	E. coli
	ABAT Protein, Human (His, SUMO, Myc) is a γ-Aminobutyric acid transaminase which is responsible for GABA metabolism. ABAT, Human is implicated in mitochondrial nucleoside metabolism, respiratory capacity, membrane potential, and mitochondrial DNA maintenance.

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Cat. No.	Product Name	Chemical Structure

HY-B1018AS

Phenelzine-d5 sulfate
Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits *GABA transaminase* and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

Phenelzine-d5 sulfate

Phenelzine-d5 sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-B0033S

Vigabatrin-13C,d2 hydrochloride
Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

Vigabatrin-13C,d2 hydrochloride

Vigabatrin- ¹³C,d₂ (hydrochloride) is the ¹³C- and deuterium labeled Vigabatrin (hydrochloride). Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

HY-W778008

Rac-Vigabatrin-13C,d2 (Major)
Rac-Vigabatrin- ¹³C,d₂ (Major) is the deuterium and ¹³C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

Rac-Vigabatrin-13C,d2 (Major)

Rac-Vigabatrin- ¹³C,d₂ (Major) is the deuterium and ¹³C labeled Vigabatrin (HY-15399). Vigabatrin (γ-Vinyl-GABA), an inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase .

Host:	Rabbit (3)
Reactivity:	Mouse (1) Rat (3)
Application:	IHC-P (1) IF-Tissue (1) IP (3) IHC-F (1) WB (3)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (1) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82219

	ABAT Antibody (YA1964) ABAT; GABA transaminase; GABA transferase; GABAT; LAIBAT	WB, IP	Rat
	ABAT Antibody (YA1964) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ABAT.

HY-P82219A

	ABAT Antibody (YA1964)(PBS only) ABAT; GABA transaminase; GABA transferase; GABAT; LAIBAT	WB, IP	Rat
	ABAT Antibody (YA1964) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ABAT.

HY-P87993

	ABAT Antibody (YA7678) GABAT, ABAT, (S)-3-amino-2-methylpropionate transaminase, GABA aminotransferase, Gamma-amino-N-butyrate transaminase, L-AIBAT, GABA-AT, GABA transaminase, GABA-T	WB, IHC-P, IHC-F, IF-Tissue, IP	Mouse, Rat
	ABAT Antibody (YA7678) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ABAT.

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Cat. No.	Product Name		Classification

HY-131693A

*γ-Acetylenic GABA* hydrochloride** GAG hydrochloride		Alkynes
γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of *GABA-transaminase. γ-Acetylenic GABA* hydrochloride can increase the concentration of GABA in rat brain . γ-Acetylenic GABA (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131693

γ-Acetylenic GABA GAG		Alkynes
γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of *GABA-transaminase. γ-Acetylenic GABA* can increase the concentration of GABA in rat brain . γ-Acetylenic GABA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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