103451-26-9
103451-26-9
Chemical Structure
γ-Acetylenic GABA hydrochloride
Synonym(s): GAG hydrochloride
- CAS No.: 103451-26-9
- Formula:C6H10ClNO2
- Molecular Weight:163.60
InChIKey: ZAVKUGNSMAPIEF-UHFFFAOYSA-N
SMILES: C#CC(N)CCC(O)=O.Cl
Biological Activity: γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride can increase the concentration of GABA in rat brain[1][2][3]. γ-Acetylenic GABA (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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γ-Acetylenic GABA hydrochloride | 99.64% | γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride can increase the concentration of GABA in rat brain. γ-Acetylenic GABA (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.96
HY-131693γ-Acetylenic GABA -
Similarity Score 0.84
HY-140345AL-Homopropargylglycine hydrochloride -
Similarity Score 0.81
HY-140345L-Homopropargylglycine -
Similarity Score 0.81
HY-W259668Homopropargylglycine -
Similarity Score 0.81
HY-B0033RVigabatrin hydrochloride (Standard) -
Similarity Score 0.79
HY-W051612DL-Propargylglycine hydrochloride -
Similarity Score 0.78
HY-15399RVigabatrin (Standard) -
Similarity Score 0.78
HY-Y12304-Pentynoic acid -
Similarity Score 0.77
HY-W016319(S)-2-aminopentanedioic acid hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37(12):1376-9. [Content Brief]
- [2]. Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50(4):325-36. [Content Brief]
- [3]. Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13;(4):CD000203. [Content Brief]
