Homopropargylglycine

Name: Homopropargylglycine
Brand: MedChemExpress
SKU: HY-W259668
Rating: 4.5 (1 reviews)

Cat. No.: HY-W259668 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Homopropargylglycine is a Methionine (HY-13694) analogue. Homopropargylglycine is incorporated at a suitable rate into newly synthesized proteins in a variety of systems, including mammalian cell culture. Homopropargylglycine can be used to identify old and new protein populations. Homopropargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Homopropargylglycine Chemical Structure

CAS No. : 215160-72-8

Size	Price	Stock	Quantity
5 mg	USD 64	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 97	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 248	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Homopropargylglycine:

L-Homopropargylglycine In-stock
L-Homopropargylglycine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Homopropargylglycine is a Methionine (HY-13694) analogue. Homopropargylglycine is incorporated at a suitable rate into newly synthesized proteins in a variety of systems, including mammalian cell culture. Homopropargylglycine can be used to identify old and new protein populations^[1]. Homopropargylglycine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Homopropargylglycine enables Bio-Orthogonal Non-Canonical Amino acid Tagging (BONCAT) of a small sample of the proteins being synthesized in Arabidopsis plants or cell cultures, facilitating their click-chemistry enrichment for analysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

127.14

Formula

C₆H₉NO₂

CAS No.

215160-72-8

Appearance

Solid

Color

White to yellow

SMILES

C#CCCC(N)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1966.34 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.8653 mL	39.3267 mL	78.6535 mL
5 mM	1.5731 mL	7.8653 mL	15.7307 mL
10 mM	0.7865 mL	3.9327 mL	7.8653 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (245 KB) HNMR (130 KB)

Handling Instructions (2659 KB)

References

[1]. Tivendale ND, Millar AH, et al. In vivo homopropargylglycine incorporation enables sampling, isolation and characterization of nascent proteins from Arabidopsis thaliana. Plant J. 2021 Aug;107(4):1260-1276. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.8653 mL	39.3267 mL	78.6535 mL	196.6336 mL
	5 mM	1.5731 mL	7.8653 mL	15.7307 mL	39.3267 mL
	10 mM	0.7865 mL	3.9327 mL	7.8653 mL	19.6634 mL
	15 mM	0.5244 mL	2.6218 mL	5.2436 mL	13.1089 mL
	20 mM	0.3933 mL	1.9663 mL	3.9327 mL	9.8317 mL
	25 mM	0.3146 mL	1.5731 mL	3.1461 mL	7.8653 mL
	30 mM	0.2622 mL	1.3109 mL	2.6218 mL	6.5545 mL
	40 mM	0.1966 mL	0.9832 mL	1.9663 mL	4.9158 mL
	50 mM	0.1573 mL	0.7865 mL	1.5731 mL	3.9327 mL
	60 mM	0.1311 mL	0.6554 mL	1.3109 mL	3.2772 mL
	80 mM	0.0983 mL	0.4916 mL	0.9832 mL	2.4579 mL
	100 mM	0.0787 mL	0.3933 mL	0.7865 mL	1.9663 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homopropargylglycine215160-72-8OthersMethionineprotein synthesisInhibitorinhibitorinhibit

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Homopropargylglycine

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Other Forms of Homopropargylglycine: