640897-20-7
640897-20-7
Chemical Structure
CPP-115
- CAS No.: 640897-20-7
- Formula:C7H9F2NO2
- Molecular Weight:177.15
IUPAC Name: (1S,3S)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid
InChIKey: CBSRETZPFOBWNG-UCORVYFPSA-N
SMILES: OC([C@H]1C/C([C@H](C1)N)=C(F)\F)=O
Biological Activity: CPP-115 is a GABA transaminase inactivator with higher affinity and lower retinal toxicity than Vigabatrin (HY-15399). CPP-115 increases brain GABA levels by inhibiting GABA transaminase catabolism. CPP-115 can be used in the study of drug addiction and infantile spasms[1].
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CPP-115 | CPP-115 is a GABA transaminase inactivator with higher affinity and lower retinal toxicity than Vigabatrin (HY-15399). CPP-115 increases brain GABA levels by inhibiting GABA transaminase catabolism. CPP-115 can be used in the study of drug addiction and infantile spasms. | |||||||||||||||||||||
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References
- [1]. Silverman R B, et al. The 2011 EB Hershberg Award for important discoveries in medicinally active substances:(1 S, 3 S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms[J]. Journal of medicinal chemistry, 2012, 55(2): 567-575. [Content Brief]
Keywords
