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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
H3K79 methyltransferase
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "H3K79 methyltransferase" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-16705
CAS No.: 1374601-40-7
Target:
Research Areas:
BRD4770 is a histone methyltransferase G9a inhibitor. BRD4770 reduces di- and trimethylation of lysine 9 on histone H3 (H3K9) with an EC50 of 5 μM, and has less or little effect toward H3K27me3, H3K36me3, H3K4me3, and H3K79me3. BRD4770 can activate the ataxia telangiectasia mutated (ATM) pathway and induce cell senescence .
2
2 Cited Publications
Target:
Research Areas:
Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 0.17 nM .
1
1 Cited Publications
Target:
Research Areas:
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM .
Cat. No.: HY-135129
CAS No.: 2565705-01-1
Target:
Research Areas:
Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM .
Cat. No.: HY-146724
CAS No.: 2580940-76-5
Target:
Research Areas:
Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells .
Cat. No.: HY-P75283
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DOT1L; Lysine N-methyltransferase 4; DOT1 Like Histone Lysine methyltransferase; DOT1-Like Protein; KMT4; H3-K79-HMTase; Histone-Lysine N-methyltransferase, H3 Lysine-79 Specific; DOT1-Like, Histone H3 methyltransferase (S. Cerevisiae); Histone H3-K79 Met
Species:
Human
Source:
E. coli
Cat. No.: HY-P704190
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DOT1L; Lysine N-methyltransferase 4; DOT1 Like Histone Lysine methyltransferase; DOT1-Like Protein; KMT4; H3-K79-HMTase; Histone-Lysine N-methyltransferase, H3 Lysine-79 Specific; DOT1-Like, Histone H3 methyltransferase (S. Cerevisiae); Histone H3-K79 Met
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-115619
Target:
Research Areas:
EPZ004777 formate is an effective and selective DOT1L inhibitor, with IC50 being 0.4 nM. EPZ004777 formate reduces the levels of H3K79me2 and H3K79me1, significantly down-regulating the expression of HOXA9 and MEIS1. EPZ004777 formate selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis (apoptosis) of leukemia cells. EPZ004777 formate can be used for the study of leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
