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Results for "

H9-KGDEVD-MMAE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Caspase (4) Fluorescent Dye (2) Orexin Receptor (OX Receptor) (1) Prion Protein (1)
By Research Areas:	Cancer (3)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-P1001

*Ac-DEVD-CHO* Maximum Cited Publications 46 Publications Verification	Caspase	Cancer
Ac-DEVD-CHO is a Caspase-3 inhibitor with a K_i value of 230 pM.

HY-P1006

*Ac-DEVD-pNA* 1 Publications Verification	Caspase	Others
Ac-DEVD-pNA is a ligand for caspase-3/-7 and related cysteine proteases .

HY-P1005

*Ac-DEVD-AFC* 10+ Cited Publications	Fluorescent Dye	Cancer
Ac-DEVD-AFC is a fluorogenic substrate (λ_ex=400 nm, λ_em=530 nm).

HY-P1003

*Ac-DEVD-AMC* 4 Publications Verification	Fluorescent Dye	Others
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-183849

*H9-KGDEVD-MMAE*	Antibody-Drug Conjugates (ADCs) Prion Protein	Cancer
H9-KGDEVD-MMAE is an antibody-drug conjugate that specifically binds to PRND to enable precise drug delivery to tumor vasculature and cancer cells. H9-KGDEVD-MMAE contains a linker cleavable by cathepsin B and caspase-3/7, allowing the release of MMAE in lysosomes. H9-KGDEVD-MMAE induces apoptosis, produces a bystander effect, and disrupts tumor vasculature. H9-KGDEVD-MMAE achieves deep tumor penetration and exhibits durable anti-tumor efficacy without systemic toxicity in preclinical models of highly vascularized malignant tumors. H9-KGDEVD-MMAE can be applied to research related to glioblastoma, sarcoma, and renal cell carcinoma .

HY-P5830

*Biotin-DEVD-CHO*	Caspase	Others
Biotin-DEVD-CHO can be used for affinity labeling of Caspase-8 following in vitro caspase cleavage .

HY-P5830A

*Biotin-DEVD-CHO TFA*	Caspase Orexin Receptor (OX Receptor)	Others
Biotin-DEVD-CHO (TFA) is a biotin-conjugated form of the caspase-3 and -7 inhibitor – Ac-DEVD-CHO. Biotin-DEVD-CHO (TFA) can be used for affinity purification of the active caspase-3, -6, -7, and -8. Biotin-DEVD-CHO (TFA) can detect the active caspase-3 in vitro .

Cat. No.	Nombre del producto	Type

HY-P1005

*Ac-DEVD-AFC* 10+ Cited Publications	Fluorescent Dyes
Ac-DEVD-AFC is a fluorogenic substrate (λ_ex=400 nm, λ_em=530 nm).

HY-P1003

*Ac-DEVD-AMC* 4 Publications Verification	Fluorescent Dyes
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

Cat. No.	Nombre del producto	Target	Research Area

HY-P1001

*Ac-DEVD-CHO* Maximum Cited Publications 46 Publications Verification	Caspase	Cancer
Ac-DEVD-CHO is a Caspase-3 inhibitor with a K_i value of 230 pM.

HY-P1006

*Ac-DEVD-pNA* 1 Publications Verification	Caspase	Others
Ac-DEVD-pNA is a ligand for caspase-3/-7 and related cysteine proteases .

HY-P1005

*Ac-DEVD-AFC* 10+ Cited Publications	Fluorescent Dye	Cancer
Ac-DEVD-AFC is a fluorogenic substrate (λ_ex=400 nm, λ_em=530 nm).

HY-P1003

*Ac-DEVD-AMC* 4 Publications Verification	Fluorescent Dye	Others
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-P5830

*Biotin-DEVD-CHO*	Caspase	Others
Biotin-DEVD-CHO can be used for affinity labeling of Caspase-8 following in vitro caspase cleavage .

HY-P5830A

*Biotin-DEVD-CHO TFA*	Caspase Orexin Receptor (OX Receptor)	Others
Biotin-DEVD-CHO (TFA) is a biotin-conjugated form of the caspase-3 and -7 inhibitor – Ac-DEVD-CHO. Biotin-DEVD-CHO (TFA) can be used for affinity purification of the active caspase-3, -6, -7, and -8. Biotin-DEVD-CHO (TFA) can detect the active caspase-3 in vitro .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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