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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Hemochromatosis
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Hemochromatosis" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia .
Cat. No.: HY-P10272
CAS No.: 1628323-80-7
Synonyms: PTG-300
Target:
Research Areas:
Cat. No.: HY-P3494
CAS No.: 1356390-47-0
Research Areas:
Cat. No.: HY-130136A
Target:
Research Areas:
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .
Cat. No.: HY-147278
CAS No.: 2646704-10-9
Synonyms: Divesiran; SLN124
Research Areas:
Manusiran (Divesiran) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .
Cat. No.: HY-130136
CAS No.: 2088415-78-3
Target:
Research Areas:
TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice .
Cat. No.: HY-P11260
CAS No.: 3051556-89-6
Target:
Research Areas:
Cat. No.: HY-147278A
Synonyms: Divesiran sodium; SLN124 sodium
Research Areas:
Manusiran sodium (Divesiran sodium) is a GalNac-siRNA targeting liver and transmembrane serine protease 6 (Serine protease 6). Manusiran sodium increases hepatic Hepcidin synthesis and plasma levels by silencing TMPRSS6, a negative regulator of hepcidin production, and limits the availability of iron required for erythropoiesis. Combined use of Manusiran sodium with Deferiprone (HY-B0568) reduces ineffective erythropoiesis and hepatic iron overload in a mouse model of β-thalassemia. Manusiran sodium can be used for research on polycythemia vera, type 1 hereditary hemochromatosis, and β-thalassemia .
Cat. No.: HY-P703961
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HJV; Haemojuvelin; Prev. HFE2; JH; Hemojuvelin; Hemochromatosis Type 2 (Juvenile); RGMC; Hemochromatosis Type 2 Protein; RGM Domain Family Member C; Repulsive Guidance Molecule C; Hemojuvelin BMP Coreceptor; Hemojuvelin BMP Co-Receptor; HFE2A
Species:
Human
Source:
HEK293
Cat. No.: HY-P78029
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HJV; Haemojuvelin; Prev. HFE2; JH; Hemojuvelin; Hemochromatosis Type 2 (Juvenile); RGMC; Hemochromatosis Type 2 Protein; RGM Domain Family Member C; Repulsive Guidance Molecule C; Hemojuvelin BMP Coreceptor; Hemojuvelin BMP Co-Receptor; HFE2A
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78028
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HJV; Haemojuvelin; Prev. HFE2; JH; Hemojuvelin; Hemochromatosis Type 2 (Juvenile); RGMC; Hemochromatosis Type 2 Protein; RGM Domain Family Member C; Repulsive Guidance Molecule C; Hemojuvelin BMP Coreceptor; Hemojuvelin BMP Co-Receptor; HFE2A
Species:
Human
Source:
HEK293
Cat. No.: HY-P701035
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HJV; Haemojuvelin; Prev. HFE2; JH; Hemojuvelin; Hemochromatosis Type 2 (Juvenile); RGMC; Hemochromatosis Type 2 Protein; RGM Domain Family Member C; Repulsive Guidance Molecule C; Hemojuvelin BMP Coreceptor; Hemojuvelin BMP Co-Receptor; HFE2A
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P703949
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: HJV; Haemojuvelin; Prev. HFE2; JH; Hemojuvelin; Hemochromatosis Type 2 (Juvenile); RGMC; Hemochromatosis Type 2 Protein; RGM Domain Family Member C; Repulsive Guidance Molecule C; Hemojuvelin BMP Coreceptor; Hemojuvelin BMP Co-Receptor; HFE2A
Species:
Human
Source:
HEK293
Cat. No.: HY-180217
Research Areas:
WGU55 is a selective and potent reversible type II transmembrane serine protease TMPRSS6 inhibitor with a Ki of 12.15 nM. WGU55 inhibits TMPRSS6 activity with an IC50 of 138 nMin KEK293 cells. WGU55 has a Ki of 3510 nM (SI = 289) against the homologous protease matriptase and a Ki of 5.2 μM against the coagulation key protease Factor Xa. WGU55 can be used for the research of iron overload related diseases, such as hereditary hemochromatosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
