Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Janus kinase 1
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Janus kinase 1" in MCE Product Catalog:
29
Target:
Research Areas:
Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research .
4
4 Cited Publications
Cat. No.: HY-P700583
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: JAK1; JTK3; Prev. JAK1B; JAK1 Protein; JAK1A; AIIDE; Tyrosine-Protein kinase JAK1; JAK-1; Janus kinase 1; Tyrosine-Protein kinase
Species:
Human
Source:
P. pastoris
3
Target:
Research Areas:
Brepocitinib (PF-06700841) is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively .
3
3 Cited Publications
Synonyms: PF-06700841 P-Tosylate
Target:
Research Areas:
Brepocitinib (PF-06700841) P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively .
1
Target:
Research Areas:
Upadacitinib (Standard) is the analytical standard of Upadacitinib. This product is intended for research and analytical applications. Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research .
1
Cat. No.: HY-19569A
CAS No.: 1607431-21-9
Synonyms: ABT-494 tartrate tetrahydrate
Target:
Research Areas:
Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research .
Cat. No.: HY-161259
Target:
Research Areas:
JAK-IN-36 (Compound 12e) is a potent and selective inhibitor of Janus Kinase 1 (JAK1) with a IC50 value of 2.2 nM. JAK-IN-36 can be used in the study of autoimmune diseases .
Cat. No.: HY-18200A
CAS No.: 474544-83-7
Synonyms: E5555 hydrochloride; ER-172594-00 hydrochloride
Research Areas:
Atopaxar hydrochloride (E5555 hydrochloride) is the hydrochloride salt form of Atopaxar (HY-18200). Atopaxar hydrochloride is an orally active, selective and reversible antagonist for thrombin receptor protease-activated receptor-1 (PAR-1). Atopaxar hydrochloride is the inhibitor for Janus kinase 1 (JAK1) and JAK2, which inhibits the JAK-STAT with EC50 of 5.90 μM in A549. Atopaxar hydrochloride inhibits the cell viability of A549 (IC50=7.02 μM), arrests the cell cycle at G1 phase and induces apoptosis. Atopaxar hydrochloride exhibits antiplatelet and antitumor activities. Atopaxar hydrochloride can be used for the research of atherothrombotic disease .
Cat. No.: HY-P705571
Synonyms: JAK1; JTK3; Prev. JAK1B; JAK1 Protein; JAK1A; AIIDE; Tyrosine-Protein kinase JAK1; JAK-1; Janus kinase 1; Tyrosine-Protein kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706063
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: JAK1; JTK3; Prev. JAK1B; JAK1 Protein; JAK1A; AIIDE; Tyrosine-Protein kinase JAK1; JAK-1; Janus kinase 1; Tyrosine-Protein kinase
Species:
Human
Source:
Sf9 insect cells
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
