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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
M1 polarization
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "M1 polarization" in MCE Product Catalog:
13
Category:
Amaranthaceae Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Achyranthes bidentata Steroids
Target:
3
Category:
Infection Colophony Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields Inflammation/Immunology
Target:
2
2 Cited Publications
Research Areas:
KPLH1130 is a pyruvate dehydrogenase kinase (PDK) inhibitor. KPLH1130 potently inhibits M1 macrophage polarization by reducing the expression of pro-inflammatory cytokines, decreasing the levels of M1 phenotype markers (HIF-1α, iNOS) and nitric oxide (NO) production. KPLH1130 prevents the reduction of mitochondrial oxygen consumption rate (OCR) induced by inflammatory stimuli (LPS ((HY-D1056) + IFN-γ) in various macrophage types. KPLH1130 improves glucose tolerance in HFD-fed mice. KPLH1130 can be used for the study of obesity-associated metabolic disorders and other inflammatory conditions .
2
2 Cited Publications
Cat. No.: HY-N7043
CAS No.: 142796-21-2
1
1
1 Cited Publications
Synonyms: ACTH; Adrenocorticotrophic hormone
Target:
Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor
Research Areas:
1
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
1
1
1 Cited Publications
Cat. No.: HY-106373A
Purity: 99.85%
Synonyms: ACTH TFA; Adrenocorticotrophic hormone TFA
Target:
Androgen Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Interleukin Related TNF Receptor
Research Areas:
Cat. No.: HY-N0730
CAS No.: 14144-06-0
Cat. No.: HY-N2909
CAS No.: 58115-31-4
Category:
Alkaloids Other Alkaloids Plants Umbelliferae Disease Research Fields Inflammation/Immunology Carphephorus corymbosus (Nutt.) Torr. & A.Gray
Target:
Cat. No.: HY-P10449
CAS No.: 3098205-40-1
Target:
Research Areas:
Cat. No.: HY-P6292
CAS No.: 2724212-01-3
Research Areas:
Research Areas:
Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity .
Cat. No.: HY-N8559
CAS No.: 40738-40-7
Cat. No.: HY-155052
CAS No.: 2642327-52-2
Target:
Research Areas:
PAD4-IN-2 is a highly tumor-targeted and irreversible PAD4 inhibitor with an IC50 of 1.94 μM. It selectively recognizes sialic acid on tumor surfaces and accumulates in tumor tissues, with distribution in the cytoplasm of tumor cells and nuclei of neutrophils. PAD4-IN-2 inhibits the PAD4-H3cit-NETs (Neutrophil Extracellular Traps) pathway, reduces senescent tumor-associated neutrophils, and promotes M1 macrophage polarization. The compound exhibits potent anti-tumor and anti-metastatic activities and is suitable for breast cancer research .
Cat. No.: HY-155052A
Purity: 95.64%
Target:
Research Areas:
PAD4-IN-2 TFA is a highly tumor-targeted and irreversible PAD4 inhibitor with an IC50 of 1.94 μM. PAD4-IN-2 TFA selectively recognizes sialic acid on tumor surfaces and accumulates in tumor tissues, with distribution in the cytoplasm of tumor cells and nuclei of neutrophils. PAD4-IN-2 TFA inhibits the PAD4-H3cit-NETs (Neutrophil Extracellular Traps) pathway, reduces senescent tumor-associated neutrophils, and promotes M1 macrophage polarization. The compound exhibits potent anti-tumor and anti-metastatic activities and is suitable for breast cancer research .
Cat. No.: HY-145491
CAS No.: 578008-43-2
Cat. No.: HY-179047
CAS No.: 3040320-18-8
Research Areas:
SMU-L11-R is a selective TLR7 agonist with an EC50 of 0.012 μM for human TLR7. SMU-L11-R specifically activates TLR7, recruits MyD88, and triggers MAPK/NF-κB pathways, leading to TNF-α/IL-1β/IL-6 secretion in both mouse and human peripheral blood mononuclear cells. SMU-L11-R promotes M1-like macrophage polarization. SMU-L11-R exhibits excellent synergistic anti-tumor effects with PD-L1 inhibitors by upregulating CD8 +T cells. SMU-L11-R shows potential in colorectal cancer studies .
Cat. No.: HY-178983
CAS No.: 2949435-53-2
Research Areas:
SHP2-IN-45 (Compound 6) is a potent, highly selective, and orally active SHP2 allosteric inhibitor. SHP2-IN-45 significantly reduces the expressions of IL-6, TNF-α, IL-1β, and iNOS. SHP2-IN-45 inhibits the polarization of M1-type macrophages. SHP2-IN-45 can inhibit the NF-κB pathway. SHP2-IN-45 can be used in the research of sepsis and acute lung injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
