514-10-3
514-10-3
Chemical Structure
Abietic acid
- CAS No.: 514-10-3
- Formula:C20H30O2
- Molecular Weight:302.45
IUPAC Name: (1R,4aR,4bR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid
InChIKey: RSWGJHLUYNHPMX-RMGPQRKISA-N
SMILES: C[C@@]1(C2[C@@](CCC1)(C)[C@@]3([H])CCC(C(C)C)=CC3=CC2)C(O)=O
Biological Activity:
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Abietic acid | 92.70% | Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis. |
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Neoabietic acid | Neoabietic acid, an abietic-type acid, is a nature product that could be isolated from the oleoresin and rosin of Pinus palustris. Neoabietic acid is highly susceptible to mineral acid. Neoabietic acid has antibacterial activity. | |||||||||||||||||||||
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Palustric acid (Standard) | ≥98% | Palustric acid (Standard) is the analytical standard of Palustric acid (HY-133593). This product is intended for research and analytical applications. Palustric acid is an abietane-type diterpenoid that is found in Pinus palustris, Pinus caribaea, and rosin. | ||||||||||||||||||||
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Sandaracopimaric acid | 98.86% | Sandaracopimaric acid is a diterpenoid with anti-inflammatory effect. Sandaracopimaric acid reduces the contraction of phenylephrine-induced pulmonary arteries with an EC50 of 43.93 μM. | ||||||||||||||||||||
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Dihydroisopimaric acid | Dihydroisopimaric acid activates large conductance Ca2+ activated K+ (BK) channels alphabeta1 in the direct measurement of BKalphabeta1 opening under whole-cell voltage clamp. | |||||||||||||||||||||
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13-Keto-8(14)-Podocarpen-18-oic acid | 13-Keto-8(14)-Podocarpen-18-oic acid (compound 16) is a compound isolated from Pinus massoniana Lamb. | |||||||||||||||||||||
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12-Hydroxyabietic acid | 12-Hydroxyabietic acid is a natural product. | |||||||||||||||||||||
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12α-Methoxyabietic acid | 12α-Methoxyabietic acid is a natural diterpene. | |||||||||||||||||||||
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Isopimaric acid | 99.88% | Isopimaric acid is a coniferous tree defense compound. Isopimaric acid binds to AKT and inhibits mTOR phosphorylation, thereby regulating the AKT/mTOR pathway. Isopimaric acid inhibits oxidative stress, inflammation, microglial migration, apoptosis, autophagic flux, ornithine decarboxylase activity, breast cancer proliferation and metastasis, and fungal spore germination. Isopimaric acid also induces M2 microglial polarization, mitochondrial damage, ROS accumulation, starvation-induced colon cancer cell apoptosis, and breast cancer cell cycle arrest. Isopimaric acid activates potassium channels, regulates sodium channels and calcium channels, reduces myocardial excitability, and improves arrhythmia. Isopimaric acid acts as an oxidative substrate for CYP6BW1/3, down-regulates PINK1/Parkin, and regulates calcium homeostasis, oxidative phosphorylation, EMT, and the Wnt pathway. Isopimaric acid exhibits activity against drug-resistant Staphylococcus aureus, repels feeding, and promotes the growth of rice seedlings. Isopimaric acid is suitable for research related to epilepsy, tumors, drug-resistant bacterial infections, atrial fibrillation, hypertension, hyperlipidemia, pulmonary tuberculosis, etc. | ||||||||||||||||||||
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Continentalic acid (Standard) | ≥98% | Continentalic acid (Standard) is the analytical standard of Continentalic acid (HY-N6908). This product is intended for research and analytical applications. Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections. | ||||||||||||||||||||
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Methyl abietate | Methyl abietate is a methyl ester derivative of abietic acid, which can be extracted from the rosin of Pinus elliottii engelm. and Pinus massoniana Lamb. Methyl abietate can be produced via the esterification of abietic acid or abietic acid contained in rosin with methanol, and can also be prepared through hydrogenation to yield hydrogenated abietic acid methyl ester. | |||||||||||||||||||||
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References
- [1]. Ulusu NN, et al. Abietic acid inhibits lipoxygenase activity. Phytother Res. 2002 Feb;16(1):88-90. [Content Brief]
- [2]. Park JY, et al. Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice[J]. J Ethnopharmacol. 2017 May 5;203:279-287. [Content Brief]
- [3]. Liu X, et al. Abietic acid suppresses non-small-cell lung cancer cell growth via blocking IKKβ/NF-κB signaling[J]. Onco Targets Ther. 2019 Jun 20;12:4825-4837. [Content Brief]
- [4]. Fernández MA, et al. Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea. J Pharm Pharmacol. 2001 Jun;53(6):867-72. [Content Brief]
- [5]. An Y, et al. Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis[J]. Int Immunopharmacol. 2023 May;118:110029. [Content Brief]
- [6]. Fang H, et al. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization[J]. Exp Anim. 2022 Nov 10;71(4):481-490. [Content Brief]
- [7]. Li XQ, et al. Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice[J]. J Ethnopharmacol. 2021 May 23;272:113934. [Content Brief]
