Abietic acid inhibits lipoxygenase activity

  • Phytother Res. 2002 Feb;16(1):88-90. doi: 10.1002/ptr.983.
N Nuray Ulusu  1 ,  Dilek Ercil ,  M Koray Sakar ,  E Ferhan Tezcan
Affiliations
  • 1. Hacettepe University, Faculty of Medicine, Department of Biochemistry, 06100 Ankara, Turkey.
PMID: 11807975 DOI: 10.1002/ptr.983
Abstract

In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined. Since the Lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.

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