40738-40-7
Chemical Structure
Aloesone
- CAS No.: 40738-40-7
- Formula:C13H12O4
- Molecular Weight:232.23
IUPAC Name: 7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-chromen-4-one
InChIKey: JHELBXAAAYUKCT-UHFFFAOYSA-N
SMILES: O=C1C=C(CC(C)=O)OC2=CC(O)=CC(C)=C12
Biological Activity: Aloesone is an orally active phenolic heptaketide natural product that can cross the blood-brain barrier. Aloesone inhibits LPS-induced oxidative stress, inflammation, M1 polarization and apoptosis in RAW264.7 macrophages by reducing ROS production and NO release, and downregulating the mRNA expression of iNOS, IL-1β and TNF-α. Aloesone also inhibits glutamate-induced neuronal damage and pentylenetetrazol (PTZ)-induced seizures by activating c-SRC[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aloesone | 99.49% | Aloesone is an orally active phenolic heptaketide natural product that can cross the blood-brain barrier. Aloesone inhibits LPS-induced oxidative stress, inflammation, M1 polarization and apoptosis in RAW264.7 macrophages by reducing ROS production and NO release, and downregulating the mRNA expression of iNOS, IL-1β and TNF-α. Aloesone also inhibits glutamate-induced neuronal damage and pentylenetetrazol (PTZ)-induced seizures by activating c-SRC. | ||||||||||||||||||||
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References
- [1]. Wang Y, et al. Multiple Beneficial Effects of Aloesone from on LPS-Induced RAW264.7 Cells, Including the Inhibition of Oxidative Stress, Inflammation, M1 Polarization, and Apoptosis. Molecules (Basel, Switzerland). 2023 Feb 08;28(4):1617. [Content Brief]
- [2]. Ren X, et al. Determination of aloesone in rat plasma by LC-MS/MS spectrometry and its application in a pharmacokinetic study. Bioanalysis. 2024;16(10):453-460.
- [3]. Wang Y, et al. Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models. Front Pharmacol. 2022 Aug 12;13:962223.
- [4]. Reza Nazifi SM, et al. Antioxidant properties of Aloe vera components: a DFT theoretical evaluation. Free Radic Res. 2019 Aug;53(8):922-931. [Content Brief]
- [5]. Mizuuchi Y, et al. Novel type III polyketide synthases from Aloe arborescens. The FEBS journal. 2009 Apr;276(8):2391-401.
- [6]. Putkaradze N, et al. Enzymatic glycosylation of aloesone performed by plant UDP-dependent glycosyltransferases. Glycobiology. 2024 Jul 26;34(9):cwae050.
- [7]. Abe I, et al. Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase. The FEBS journal. 2006 Jan;273(1):208-18.
