9 Results for "

MAPK/ERK inhibition

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "MAPK/ERK inhibition" in MCE Product Catalog:

2
(+)-Columbianetin
(+)-Columbianetin
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2 Cited Publications
Cat. No.: HY-N0363
CAS No.: 3804-70-4
Synonyms: (S)-Columbianetin
Category:  

Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Disease Research Fields Inflammation/Immunology

Target:  

ERK JNK Collagen TGF-beta/Smad p38 MAPK Reactive Oxygen Species (ROS)

(+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging .
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2
(+)-Columbianetin acetate
(+)-Columbianetin acetate
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2 Cited Publications
Cat. No.: HY-N0363A
CAS No.: 23180-65-6
Synonyms: (S)-Columbianetin acetate
Category:  

other families Coumarins Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Fungal

(+)-Columbianetin ((S)-Columbianetin) acetate acts as an inhibitor of JNK/ERK. (+)-Columbianetin acetate inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin acetate regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin acetate is applicable to research related to skin aging .
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Methyl protodioscin
Methyl protodioscin
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Cat. No.: HY-N0863
CAS No.: 54522-52-0
Synonyms: NSC-698790; Smilax saponin B
Category:  

other families Plants Disease Research Fields Cancer Steroids

Target:  

Bcl-2 Family Apoptosis Akt c-Myc ERK p38 MAPK JNK FOXO

Methyl protodioscin (NSC-698790; Smilax saponin B) is a multi-target, selective, steroidal diglycoside inhibitor with antitumor activity that induces cell cycle arrest. The mechanism of action of Methyl protodioscin is complex, involving the induction of G2/M cell cycle arrest, regulation of the Bcl-2/Bax apoptotic pathway, inhibition of the Akt1/c-Myc axis and MAPK/ERK signaling, while simultaneously downregulating ADAM15 and inducing FOXO1 to reduce cholesterol synthesis. It also inhibits the JNK/c-Jun pathway, reducing the production of inflammatory factors (IL-6, TNF-α). Methyl protodioscin exhibits significant antitumor (inhibiting proliferation, migration, invasion, and inducing apoptosis), anti-inflammatory, and anti-restenosis activities. Methyl protodioscin can be used in research on lung cancer, prostate cancer, pancreatic cancer, and other tumors, as well as inflammatory diseases such as airway inflammation and enteritis .
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Grasshopper ketone
Grasshopper ketone
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Cat. No.: HY-N9866
CAS No.: 41703-38-2
Category:  

Natural Products Plants Actaea dahurica Turcz. ex Fisch. & C. A. Mey. Rhamnaceae

Target:  

Others

It is a bioactive compound with anti-inflammatory activity that inhibits LPS-induced NO production in RAW 264.7 cells and acts by inhibiting the phosphorylation of MAPK (ERK, JNK and p38) and NF-κB p65. Grasshopper ketone, as an ingredient, has shown its potential in anti-inflammatory inhibition .
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(+)-Columbianetin acetate (Standard)
(+)-Columbianetin acetate (Standard)
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Cat. No.: HY-N0363AR
CAS No.: 23180-65-6
Synonyms: (S)-Columbianetin acetate (Standard)
Category:  

other families Coumarins Phenylpropanoids Plants

Target:  

Reference Standards Fungal

(+)-Columbianetin acetate (Standard) is the analytical standard of (+)-Columbianetin acetate (HY-N0363A). This product is intended for research and analytical applications. (+)-Columbianetin acetate ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin acetate inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin acetate regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin acetate is applicable to research related to skin aging .
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(+)-Columbianetin (Standard)
(+)-Columbianetin (Standard)
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Cat. No.: HY-N0363R
CAS No.: 3804-70-4
Synonyms: (S)-Columbianetin (Standard)
Category:  

Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense

Target:  

Reference Standards Collagen p38 MAPK ERK TGF-beta/Smad JNK Reactive Oxygen Species (ROS)

(+)-Columbianetin (Standard) is the analytical standard of (+)-Columbianetin (HY-N0363). This product is intended for research and analytical applications. (+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging .
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MptpB-IN-3
MptpB-IN-3
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Cat. No.: HY-183688
CAS No.: 3104354-58-4
Target:  

Bacterial Phosphatase p38 MAPK ERK

Research Areas:  

Infection

MptpB-IN-3 is a selective inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC50 of 0.19 μM. MptpB-IN-3 blocks MptpB-mediated inhibition of the macrophage MAPK pathway and restores the phosphorylation levels of Erk1/2 and p38. MptpB-IN-3 exhibits direct anti-tuberculosis activity against Mycobacterium tuberculosis and reduces the Mycobacterium tuberculosis load in mouse macrophages. MptpB-IN-3 can be used for tuberculosis research .
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MEK-IN-10
MEK-IN-10
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Cat. No.: HY-183674
CAS No.: 3096958-11-8
Target:  

Molecular Glues MEK Raf PERK Ras p38 MAPK Apoptosis

Research Areas:  

Cancer

MEK-IN-10 is an orally active pan-MEK/RAF non-degrading molecular glue with an IC50 of 782 nM against human MEK1. MEK-IN-10 blocks the phosphorylation of MEK and ERK, induces and stabilizes the MEK1-RAF complex, and disrupts the RAS-MAPK signaling pathway. MEK-IN-10 induces apoptosis in cancer cells and arrests cells at the G0/G1 phase. MEK-IN-10 induces tumor growth inhibition in mouse xenograft models. MEK-IN-10 can be used in the research of RAS-driven cancers, such as colorectal cancer and pancreatic cancer .
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DC-120
DC-120
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Cat. No.: HY-119884
CAS No.: 1261080-40-3
Target:  

Akt FOXO GSK-3 Apoptosis Calmodulin Raf MEK ERK mTOR

Research Areas:  

Cancer

DC-120 is an ATP-competitive AKT inhibitor, with particular activity against AKT1 (an IC50 of 0.153 μM). DC-120 functionally blocks AKT kinase activity and reduces the phosphorylation levels of FOXO3a and GSK-3β. DC-120 induces cancer cell apoptosis (apoptosis) and inhibits cancer cell proliferation. DC-120 activates the mTORC1 pathway via the Ca 2+/calmodulin (calmodulin)/hVps34 signaling pathway. DC-120 abrogates AKT-mediated inhibition of CRAF, thereby activating the MEK/ERK MAPK pathway. DC-120 exerts anti-tumor activity in a nude mouse hepatocellular carcinoma xenograft model. DC-120 can be used for hepatocellular carcinoma-related research .
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