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MELK inhibitor

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By Targets:	MELK (12) Akt (1) Apoptosis (1) CDK (2) COX (1) DYRK (2) Estrogen Receptor/ERR (1) FLT3 (2) GSK-3 (2) Haspin Kinase (1) Mitosis (1) mTOR (2) PDGFR (1) Pim (2) Reference Standards (2) RIP kinase (2)
By Research Areas:	Cancer (12) Inflammation/Immunology (1)

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Targets Recommended: MELK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15512

OTSSP167 Maximum Cited Publications 22 Publications Verification OTS167	MELK	Cancer
OTSSP167 (OTS167) is a highly potent and ATP-competitive *MELK* inhibitor with IC₅₀ value of 0.41 nM.

HY-15512A

OTSSP167 hydrochloride Maximum Cited Publications 22 Publications Verification OTS167 hydrochloride	MELK	Cancer
OTSSP167 (OTS167) hydrochloride is a highly potent and ATP-competitive *MELK* inhibitor with IC₅₀ value of 0.41 nM.

HY-100368A

MELK-8a hydrochloride 3 Publications Verification NVS-MELK8a hydrochloride	MELK	Cancer
MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC₅₀ of 2 nM.

HY-100368

MELK-8a 3 Publications Verification NVS-MELK8a	PDGFR Haspin Kinase MELK Mitosis	Cancer
MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC₅₀ of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC₅₀s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells .

HY-101515

MELK-IN-1	MELK	Cancer
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC₅₀ and a K_i of 3 nM and 0.39 nM, respectively.

HY-122665

HTH-01-091	MELK DYRK Pim mTOR CDK GSK-3 RIP kinase	Cancer
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC₅₀ of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research .

HY-12420

JNJ-47117096 hydrochloride MELK-T1 hydrochloride	MELK FLT3	Cancer
JNJ-47117096 hydrochloride is potent and selective *MELK* inhibitor, with an IC₅₀ of 23 nM, also effectively inhibits Flt3, with an IC₅₀ of 18 nM.

HY-122665A

HTH-01-091 TFA	MELK DYRK Pim mTOR CDK GSK-3 RIP kinase	Cancer
HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC₅₀ of 10.5 nM. HTH-01-091 TFA also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 TFA can be uesd for breast cancer research .

HY-12420A

JNJ-47117096	MELK FLT3	Cancer
JNJ-47117096 is potent and selective *MELK* inhibitor, with an IC₅₀ of 23 nM, also effectively inhibits Flt3, with an IC₅₀ of 18 nM .

HY-100368AR

MELK-8a hydrochloride (Standard) NVS-MELK8a hydrochloride (Standard)	MELK Reference Standards	Cancer
MELK-8a (hydrochloride) (Standard) is the analytical standard of MELK-8a (hydrochloride) (HY-100368A). This product is intended for research and analytical applications. MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.

HY-101515R

MELK-IN-1 (Standard)	MELK Reference Standards	Cancer
MELK-IN-1 (Standard) is the analytical standard of MELK-IN-1 (HY-101515). This product is intended for research and analytical applications. MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.

HY-N17632

Moracin G	Estrogen Receptor/ERR Akt MELK COX Apoptosis	Inflammation/Immunology Cancer
Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N17632

Moracin G	Structural Classification Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	Estrogen Receptor/ERR Akt MELK COX Apoptosis
Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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MELK inhibitor

Inhibitors & Agonists

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