Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
METTL3-IN-14
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "METTL3-IN-14" in MCE Product Catalog:
Cat. No.: HY-187208
METTL3-IN-14 is a METTL3 inhibitor with a target IC50 of 6.68 μM and target Kd of 8.7 μM. METTL3-IN-14 binds to the METTL3 active site, inhibits methyltransferase activity, and does not alter METTL3 mRNA or protein expression levels. METTL3-IN-14 acts as an antiviral agent, exerts anti-SARS-CoV-2 activity via non-METTL3 targets. METTL3-IN-14 can be used for the research of covid-19 .
20
20 Publications Verification
Synonyms: SAH (S-AdenosylhomocysteINe)
Category:
Human Gut Microbiota Metabolites Microorganisms Disease markers Metabolic Disease Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
3
3 Cited Publications
Cat. No.: HY-W037893
CAS No.: 122323-88-0
Synonyms: Methyl piperazINe-2-carboxylate dihydrochloride; METTL3 activator-1
Research Areas:
CHMA1004 (Methyl piperazine-2-carboxylate; METTL3 activator-1) dihydrochloride is a METTL3/METTL14/WTAP methyltransferase complex activator. CHMA1004 dihydrochloride exhibits neuroprotective and anxiolytic potential by enhancing m 6A methylation modification of RNA. CHMA1004 dihydrochloride promotes HIV replication in an infection context. CHMA1004 dihydrochloride can be used in studies related to anxiety disorders and HIV-1 infection .
2
2 Cited Publications
Cat. No.: HY-160415
CAS No.: 3066823-45-5
WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m 6A modification and proliferation of AML cells, and induces apoptosis.
2
2 Cited Publications
Cat. No.: HY-160415A
WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m 6A modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity .(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))
2
1
1 Cited Publications
Cat. No.: HY-P10387
1
1 Cited Publications
Cat. No.: HY-P10387A
Cat. No.: HY-19528S
Synonyms: SAH (S-AdenosylhomocysteINe)-d4
Cat. No.: HY-162282
CAS No.: 3039554-79-2
PROTAC METTL3-14 degrader 1 is a METTL3-METTL14 heterodimer complex PROTAC degrader. PROTAC METTL3-14 degrader 1 binds to the E3 ubiquitin ligase CRBN, forms a ternary complex with METTL3-METTL14, and promotes the ubiquitination and degradation of METTL3. PROTAC METTL3-14 degrader 1 is applicable to the research of acute myeloid leukemia and prostate cancer .
Cat. No.: HY-151924
CAS No.: 35940-03-5
Target:
Research Areas:
Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC50 value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection .
Target:
Research Areas:
Antiviral agent 24 is a potent antiviral agent with EC50 values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner .
Cat. No.: HY-19528S2
CAS No.: 2687960-02-5
Cat. No.: HY-W125425
CAS No.: 2758-98-7
Synonyms: Methyl piperazINe-2-carboxylate; METTL3 activator-1 free base
Research Areas:
CHMA1004 (Methyl piperazine-2-carboxylate; METTL3 activator-1 free base) is a METTL3/METTL14/WTAP methyltransferase complex activator . CHMA1004 exhibits neuroprotective and anxiolytic potential by enhancing m 6A methylation modification of RNA. CHMA1004 promotes HIV replication in an infection context. CHMA1004 can be used in studies related to anxiety disorders and HIV-1 infection .
Cat. No.: HY-183186
CAS No.: 3050818-07-7
Target:
Research Areas:
EP102 is an orally active, selective inhibitor of the METTL3/METTL14 complex with an IC50 of 2 nM. EP102 reduces intracellular N6-methyladenosine levels, inhibits cancer cell proliferation, and thereby suppresses tumor growth in mouse models. EP102 is applicable for the research of acute myeloid leukemia, ovarian solid tumors and advanced solid tumors .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
