3039554-79-2
Chemical Structure
PROTAC METTL3-14 degrader 1
- CAS No.: 3039554-79-2
- Formula:C51H66F2N12O6
- Molecular Weight:981.14
InChIKey: JOGQMYZIGVVNLA-UHFFFAOYSA-N
SMILES: CC1(C)CCN(CC2=C(F)C=C(N3CC4(CCN(C5=CC(NCCN6CCN(C(CCCCCNC7=C(C(N(C8CCC(NC8=O)=O)C9=O)=O)C9=CC=C7)=O)CC6)=NC=N5)CC4)NC(C3)=O)C(F)=C2)CC1
Biological Activity: PROTAC METTL3-14 degrader 1 is a METTL3-METTL14 heterodimer complex PROTAC degrader. PROTAC METTL3-14 degrader 1 binds to the E3 ubiquitin ligase CRBN, forms a ternary complex with METTL3-METTL14, and promotes the ubiquitination and degradation of METTL3. PROTAC METTL3-14 degrader 1 is applicable to the research of acute myeloid leukemia and prostate cancer[1].
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PROTAC METTL3-14 degrader 1 | PROTAC METTL3-14 degrader 1 is a METTL3-METTL14 heterodimer complex PROTAC degrader. PROTAC METTL3-14 degrader 1 binds to the E3 ubiquitin ligase CRBN, forms a ternary complex with METTL3-METTL14, and promotes the ubiquitination and degradation of METTL3. PROTAC METTL3-14 degrader 1 is applicable to the research of acute myeloid leukemia and prostate cancer. | |||||||||||||||||||||
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Keywords
