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Macrocyclic Antibiotic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (19) ADC Payload (2) Apoptosis (2) Bacterial (15) DNA/RNA Synthesis (2) FKBP (2) Fungal (4) HCV (1) Microtubule/Tubulin (3) Parasite (3) Reference Standards (5)
By Research Areas:	Cancer (3) Infection (21) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (3)

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Peptides

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Targets Recommended: Antibiotic

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17580

Fidaxomicin 5+ Cited Publications OPT-80; PAR-101	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic	Infection
Fidaxomicin (OPT-80), a macrocyclic *antibiotic, is an orally active and potent RNA polymerase* inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-15739

Ansamitocin P-3 Maximum Cited Publications 8 Publications Verification Antibiotic C 15003P3; Maytansinol isobutyrate	Microtubule/Tubulin ADC Payload Bacterial Antibiotic	Infection Cancer
Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

HY-17566

Capreomycin sulfate 5 Publications Verification	Antibiotic Bacterial	Infection Neurological Disease Metabolic Disease
Capreomycin sulfate is a macrocyclic peptide *antibiotic* that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease .

HY-13557

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide *antibiotic* with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

HY-N6686

Virginiamycin M1 2 Publications Verification Pristinamycin IIA; Ostreogrycin A	Bacterial Antibiotic	Infection
Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by?Streptomyces virginiae, is an polyunsaturated macrocyclic lactone *antibiotic* and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.

HY-107486

Nosiheptide Multhiomycin; RP 9671	Bacterial Antibiotic	Infection
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .

HY-125728

Micrococcin P1	Bacterial Parasite HCV	Infection
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC₅₀ range of 0.1-0.5 μM . Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against *S. aureus* 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively . Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum .

HY-P3270

Capreomycin	Bacterial Antibiotic	Infection
Capreomycin is a macrocyclic peptide *antibiotic. Capreomycin can be used for anti*-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

HY-107486R

Nosiheptide (Standard) Multhiomycin (Standard); RP 9671 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Nosiheptide (Standard) is the analytical standard of Nosiheptide. This product is intended for research and analytical applications. Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .

HY-13557R

Ascomycin (Standard) Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)	Reference Standards FKBP Parasite Fungal Antibiotic	Infection Neurological Disease Inflammation/Immunology
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

HY-147429A

Zosurabalpin TFA Abx MCP TFA; RG6006 TFA	Antibiotic Bacterial	Infection
Zosurabalpin TFA is a tethered macrocyclic peptide antibiotic, acting specifically on A. baumannii. Zosurabalpin TFA inhibits lipopolysaccharide-transport .

HY-139105

20-O-Demethyl-AP3	Microtubule/Tubulin	Infection Cancer
20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. Ansamitocin P-3, a microtubule inhibitor, is a macrocyclic antitumor antibiotic .

HY-17580R

Fidaxomicin (Standard) OPT-80 (Standard); PAR-101 (Standard)	Reference Standards DNA/RNA Synthesis Bacterial Apoptosis Antibiotic	Infection
Fidaxomicin (Standard) is the analytical standard of Fidaxomicin. This product is intended for research and analytical applications. Fidaxomicin (OPT-80), a macrocyclic *antibiotic, is an orally active and potent RNA polymerase* inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-N10585

Malacidin B	Antibiotic Bacterial	Infection
Malacidin B is a macrocyclic lipopeptide antibiotic that shows antibacterial activity in a calcium-dependent manner .

HY-137085

Antibiotic AB023b	Antibiotic Fungal	Infection
Antibiotic AB023b is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023a (HY-137084). Antibiotic AB023b exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea, Fusarium moniliforme and Pythium ultimum .

HY-137084

Antibiotic AB023a	Antibiotic Fungal	Infection
Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum .

HY-125512

Saccharocarcin B	Antibiotic	Infection
Saccharocarcin B is a macrocyclic lactone antibiotic that is active against the Gram-positive bacteria M. luteus and S. aureus as well as the Gram-negative bacteria C. trachomatis.

HY-15739R

Ansamitocin P-3 (Standard) Antibiotic C 15003P3 (Standard); Maytansinol isobutyrate (Standard)	Reference Standards Microtubule/Tubulin ADC Payload Bacterial Antibiotic	Infection Cancer
Ansamitocin P-3 (Standard) is the analytical standard of Ansamitocin P-3. This product is intended for research and analytical applications. Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

HY-P10700

RO7196472	Antibiotic Bacterial	Infection
RO7196472 is a potent and selective macrocyclic peptide antibiotic that targets Acinetobacter strains. RO7196472 inhibits Acinetobacter strain activity by specifically binding to the Lipopolysaccharide (LPS) binding site on the LptB2FG complex located on the inner membrane of Acinetobacter strains, thereby blocking LPS transport and suppressing Acinetobacter strain activity .

HY-N6686R

Virginiamycin M1 (Standard) Pristinamycin IIA (Standard); Ostreogrycin A (Standard)	Reference Standards Bacterial Antibiotic	Infection
Virginiamycin M1 (Standard) is the analytical standard of Virginiamycin M1. This product is intended for research and analytical applications. Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by?Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.

HY-P11676

Soralimixin BRII-693; QPX9003	Antibiotic Bacterial	Infection
Soralimixin (BRII-693), a Polymyxin derivative, is a next-generation intravenous (IV)-administered synthetic macrocyclic peptide *antibiotic*. Soralimixin can be used for the study of infections caused by drug-resistant Gram-negative pathogens .

Cat. No.	Product Name	Target	Research Area

HY-P3270

Capreomycin	Bacterial Antibiotic	Infection
Capreomycin is a macrocyclic peptide *antibiotic. Capreomycin can be used for anti*-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

HY-N10585

Malacidin B	Antibiotic Bacterial	Infection
Malacidin B is a macrocyclic lipopeptide antibiotic that shows antibacterial activity in a calcium-dependent manner .

HY-P10700

RO7196472	Antibiotic Bacterial	Infection
RO7196472 is a potent and selective macrocyclic peptide antibiotic that targets Acinetobacter strains. RO7196472 inhibits Acinetobacter strain activity by specifically binding to the Lipopolysaccharide (LPS) binding site on the LptB2FG complex located on the inner membrane of Acinetobacter strains, thereby blocking LPS transport and suppressing Acinetobacter strain activity .

HY-P11676

Soralimixin BRII-693; QPX9003	Antibiotic Bacterial	Infection
Soralimixin (BRII-693), a Polymyxin derivative, is a next-generation intravenous (IV)-administered synthetic macrocyclic peptide *antibiotic*. Soralimixin can be used for the study of infections caused by drug-resistant Gram-negative pathogens .

Fidaxomicin 5+ Cited Publications OPT-80; PAR-101	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Phenols Polyphenols Antibacterial Disease Research Disease Research Fields Source Classification	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic
Fidaxomicin (OPT-80), a macrocyclic *antibiotic, is an orally active and potent RNA polymerase* inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

Ansamitocin P-3 Maximum Cited Publications 8 Publications Verification Antibiotic C 15003P3; Maytansinol isobutyrate	Infection Microorganisms Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	Microtubule/Tubulin ADC Payload Bacterial Antibiotic
Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

Capreomycin sulfate 5 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Mammalian Cell Culture Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial
Capreomycin sulfate is a macrocyclic peptide *antibiotic* that inhibits phenylalanine synthesis in mycobacterial ribosomal translation. Capreomycin sulfate has anti-amyloidogenic and pro-fibrinolytic activities, reducing amyloid-induced cytotoxicity by inhibiting the occurrence of amyloid fibrillation. Capreomycin sulfate can be used in the study of multidrug-resistant tuberculosis, type 2 diabetes, Alzheimer's disease and Parkinson's disease .

Ascomycin 5+ Cited Publications Immunomycin; FR-900520; FK520	Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Neurological Disease Classification of Application Fields Antibiotics Disease Research Inflammation/Immunology Disease Research Fields Source Classification	FKBP Parasite Fungal Antibiotic
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide *antibiotic* with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .

Virginiamycin M1 2 Publications Verification Pristinamycin IIA; Ostreogrycin A	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by?Streptomyces virginiae, is an polyunsaturated macrocyclic lactone *antibiotic* and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.

Nosiheptide Multhiomycin; RP 9671	Infection Microorganisms Antibiotics Animal Husbandry Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Antibiotic
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .

Nosiheptide (Standard) Multhiomycin (Standard); RP 9671 (Standard)	Structural Classification Microorganisms Antibiotics Animal Husbandry Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial Antibiotic
Nosiheptide (Standard) is the analytical standard of Nosiheptide. This product is intended for research and analytical applications. Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth .

Ascomycin (Standard) Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Antibiotics Disease Research Source Classification	Reference Standards FKBP Parasite Fungal Antibiotic
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].

Fidaxomicin (Standard) OPT-80 (Standard); PAR-101 (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Antibacterial Disease Research Source Classification	Reference Standards DNA/RNA Synthesis Bacterial Apoptosis Antibiotic
Fidaxomicin (Standard) is the analytical standard of Fidaxomicin. This product is intended for research and analytical applications. Fidaxomicin (OPT-80), a macrocyclic *antibiotic, is an orally active and potent RNA polymerase* inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

Malacidin B	Natural Products Microorganisms	Antibiotic Bacterial
Malacidin B is a macrocyclic lipopeptide antibiotic that shows antibacterial activity in a calcium-dependent manner .

Ansamitocin P-3 (Standard) Antibiotic C 15003P3 (Standard); Maytansinol isobutyrate (Standard)	Structural Classification Microorganisms Antibiotics Disease Research Anticancer Other Antibiotics Source Classification	Reference Standards Microtubule/Tubulin ADC Payload Bacterial Antibiotic
Ansamitocin P-3 (Standard) is the analytical standard of Ansamitocin P-3. This product is intended for research and analytical applications. Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

Virginiamycin M1 (Standard) Pristinamycin IIA (Standard); Ostreogrycin A (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Antibacterial Disease Research Source Classification	Reference Standards Bacterial Antibiotic
Virginiamycin M1 (Standard) is the analytical standard of Virginiamycin M1. This product is intended for research and analytical applications. Virginiamycin M1 (Pristinamycin IIA; Ostreogrycin A), produced by?Streptomyces virginiae, is an polyunsaturated macrocyclic lactone antibiotic and acts as a component of Virginiamycin (HY-112665) . Virginiamycin M1 alone is against Staphylococcus aureus with a MIC of 0.25 μg/mL.

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Macrocyclic Antibiotic

Inhibitors & Agonists

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