205 Results for "

Metabolite isolated

" in MedChemExpress (MCE) Product Catalog:
Products (205)

205 Results for "Metabolite isolated" in MCE Product Catalog:

14
14 Publications Verification
Cat. No.: HY-N6979
CAS No.: 5289-74-7
Synonyms: 20-Hydroxyecdysone
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .
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12
12 Cited Publications
Cat. No.: HY-N6798
CAS No.: 35891-70-4
Synonyms: Thermozymocidin; ISP-I
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection .
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2
2 Cited Publications
Cat. No.: HY-N0745
CAS No.: 94596-28-8
Senkyunolide I is an orally active, blood-brain barrier-permeable metabolite of Z-ligustilide (HY-N0401A) . Senkyunolide I is isolated from Ligusticum chuanxiong. Senkyunolide I upregulates p-Erk1/2 and Nrf2/HO-1, and inhibits Caspase 3. Senkyunolide I alleviates Apoptosis. Senkyunolide I increases the pain threshold in mice and reduces acetic acid-induced writhing responses in mice. Senkyunolide I improves neurological deficits, reduces infarct volume and alleviates cerebral edema in rats with focal cerebral ischemia-reperfusion injury. Senkyunolide I protects renal function and structural integrity in a mouse model of renal ischemia-reperfusion injury. Senkyunolide I is applicable to research related to focal cerebral ischemia-reperfusion injury, migraine, and renal ischemia-reperfusion injury .
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1
1 Cited Publications
Cat. No.: HY-W778608
CAS No.: 38934-20-2
Synonyms: Quercetin 7-O-β-glucuronide
Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a metabolite of Quercetin (HY-18085), can be isolated from Madagascarian Uncarina species. Quercetin 7-glucuronide can inhibit LDL oxidation .
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1 Cited Publications
Cat. No.: HY-N4237
CAS No.: 5573-16-0
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca 2+]i due to Ca 2+ release from intracellular stores .
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1
1 Cited Publications
Cat. No.: HY-Y0694
CAS No.: 89-84-9
Synonyms: Resacetophenone; 1-​(2,​4-​Dihydroxyphenyl)​ethanone
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO3-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite .
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1
1 Cited Publications
Cat. No.: HY-19827
CAS No.: 28656-91-9
Synonyms: (+)-Aeroplysinin-1
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .
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1
1 Cited Publications
Cat. No.: HY-N2013
CAS No.: 13395-02-3
Synonyms: Aristololactam; Aristolactam
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis .
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Cat. No.: HY-126779
CAS No.: 549-06-4
Purity:  98.5%
Target:  

Fungal

Stictic acid is a secondary metabolite that can be isolated from the lichen Lobaria pulmonaria (L.) Hoffm. Stictic acid inhibits growth of human colon adenocarcinoma HT-29 cells (IC50: 29.29 μg/mL) .
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Cat. No.: HY-118614
CAS No.: 487-19-4
Purity:  99.35%
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .
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Cat. No.: HY-N6770
CAS No.: 10140-70-2
Synonyms: (S)-Curvularin
Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM .
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Cat. No.: HY-W002751
CAS No.: 567-61-3
6-Methylsalicylic acid is the secondary metabolite that could be isolated from some fungi. 6-Methylsalicylic acid can be used as building blocks for synthesis of antibacterial and anti-inflammatory agents .
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Cat. No.: HY-133902
CAS No.: 5187-84-8
Neoglucobrassicin is an endogenous metabolite that can be isolated from the seeds of the plant Sinapis alba L.
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Cat. No.: HY-125319
CAS No.: 169181-28-6
Purity:  98.38%
Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .
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Cat. No.: HY-119821
CAS No.: 52452-60-5
Purity:  96.58%
Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has significant α-glucosidase inhibitory activity .
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Cat. No.: HY-N3102A
CAS No.: 20649-40-5
Synonyms: (E)-p-Hydroxycinnamyl alcohol
(E)-p-Coumaryl alcohol is a metabolite of coumarin that has significant cytotoxicity. (E)-p-Coumaryl alcohol can be isolated from Alpinia officinarum and Rhodiola rosea and can be used for inflammation research .
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Cat. No.: HY-N10228
CAS No.: 4373-40-4
Gliorosein is a fungal metabolite isolated from Gliocladium. Gliorosein is isomeric with the quinol but shows a different ultraviolet absorption spectrum .
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Cat. No.: HY-121133
CAS No.: 20007-85-6
(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .
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Cat. No.: HY-N15080
CAS No.: 57528-68-4
S-2,3-Dicarboxyaziridine, a metabolite that can be isolated from a streptomyces, possesses anti-bacterial activity .
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Cat. No.: HY-W002773
CAS No.: 6702-50-7
Methyl isovanillate is a secondary metabolite isolated from Vitex agnus-castus. Methyl isovanillate does not exhibit significant activity in the DPPH free radical scavenging experiment .
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