549-06-4
Chemical Structure
Stictic acid
- CAS No.: 549-06-4
- Formula:C19H14O9
- Molecular Weight:386.31
IUPAC Name: 1,4-dihydroxy-10-methoxy-5,8-dimethyl-3,7-dioxo-1,3-dihydro-7H-benzo[6,7][1,4]dioxepino[2,3-e]isobenzofuran-11-carbaldehyde
InChIKey: SKCUFZLDTAYNBZ-UHFFFAOYSA-N
SMILES: O=CC1=C(OC(C2=C(C(OC2O)=O)C(O)=C3C)=C3OC4=O)C4=C(C)C=C1OC
Biological Activity: Stictic acid is a Depsidone. Stictic acid is found in the edible lichens Lobaria pindarensis and Lobaria pulmonaria. Stictic acid inhibits LPS/Aβ42-induced mRNA expression of iNOS, IL-1β, TNF-α, and IL-6, and decreases LPS-induced COX-2 protein expression. Stictic acid inhibits Aβ42 fibril formation and aggregation. Stictic acid scavenges superoxide anions. Stictic acid exhibits anticancer activity against colon adenocarcinoma. Stictic acid is used in research on Alzheimer's disease and colon adenocarcinoma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Stictic acid | 98.5% | Stictic acid is a Depsidone. Stictic acid is found in the edible lichens Lobaria pindarensis and Lobaria pulmonaria. Stictic acid inhibits LPS/Aβ42-induced mRNA expression of iNOS, IL-1β, TNF-α, and IL-6, and decreases LPS-induced COX-2 protein expression. Stictic acid inhibits Aβ42 fibril formation and aggregation. Stictic acid scavenges superoxide anions. Stictic acid exhibits anticancer activity against colon adenocarcinoma. Stictic acid is used in research on Alzheimer's disease and colon adenocarcinoma. | ||||||||||||||||||||
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References
- [1]. Yang M X, et al. The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: active depsidones, norstictic acid and stictic acid, are responsible for the functions[J]. Journal of Functional Foods, 2023, 107: 105607.
- [2]. Ismed F, et al. NMR reassignment of stictic acid isolated from a Sumatran lichen Stereocaulon montagneanum (Stereocaulaceae) with superoxide anion scavenging activities. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2017 Jan 01;72(1-2):55-62.
- [3]. Pejin B, et al. Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells[J]. Arabian Journal of Chemistry, 2017, 10: S1240-S1242.
