Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
Methionine adenosyltransferase 2A (MAT2A)
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "Methionine adenosyltransferase 2A (MAT2A)" in MCE Product Catalog:
19
19 Publications Verification
Research Areas:
PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.
9
9 Cited Publications
Research Areas:
FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities .
1
1 Cited Publications
Research Areas:
MAT2A inhibitor 1 is a methionine adenosyltransferase 2A (MATA2) inhibitor with an IC50 less than l00 nM .
1
1 Cited Publications
Research Areas:
AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. AGI-41998 exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 22 nM and 34 nM. AGI-41998 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-41998 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer .
Research Areas:
MAT2A inhibitor 3 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1, compound 24, has an IC50 of <200 nM. MAT2A inhibitor 3 can be used for the research of cancers .
Research Areas:
AGI-43192 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that limitedly penetrates the blood-brain barrier. AGI-43192 exhibits inhibitory activitity against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC50s of 32 and 14 nM. AGI-43192 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-43192 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer .
FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities .
Cat. No.: HY-162010
CAS No.: 2851449-24-4
Research Areas:
MAT2A-IN-13 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with a favorable pharmacokinetic profile. MAT2A-IN-13 shows in vivo potency in an HCT-116 MTAP-deleted xenograft model. MAT2A-IN-13 can be used for MTAP-Deleted tumors research .
Cat. No.: HY-170501
CAS No.: 2923986-27-8
Research Areas:
MAT2A-IN-18 (Compound 15) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC50≤50 nM .
Cat. No.: HY-170502
CAS No.: 2850245-72-4
Research Areas:
MAT2A-IN-19 (Compound I-3) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC50 of 32.93 nM .
Cat. No.: HY-168445
CAS No.: 3062073-94-0
Research Areas:
MAT2A-IN-21 (compound 28) is a potent methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 49 nM. MAT2A-IN-21 selectivity inhibits MTAP-deficient cancer cells .
Cat. No.: HY-144179
CAS No.: 2439272-57-6
Research Areas:
MAT2A-IN-4 is a methionine adenosyltransferase 2A (MAT2A) inhibitor extracted from patent WO2020123395A1 compound 426 . MAT2A-IN-4 can be used for the research of cancer .
Cat. No.: HY-170503
CAS No.: 3018834-98-2
Research Areas:
MAT2A-IN-20 (Compound A49) is an inhibitor for methionine adenosyltransferase 2A (MAT2A) with an IC50 ≤50 nM. MAT2A-IN-20 inhibits human UGT1A1 with an IC50 of 28.45 μM. MAT2A-IN-20 exhibits antitumor in mouse models .
Cat. No.: HY-173281
CAS No.: 3031093-57-6
Research Areas:
MAT2A-IN-24 (Compound 9) is an inhibitor of methionine adenosyltransferase 2a (MAT2a). The IC50 value for the inhibition of MAT2a is 20 nM, and the IC50 value for the antiproliferative activity against HAP1MTAP–/– cells is 10 nM. MAT2A-IN-24 can be used in the research field of tumor diseases associated with MTAP deficiency .
Cat. No.: HY-P703574
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAT2A; Methionine adenosyltransferase 2; Methionine adenosyltransferase 2A; AdoMet Synthase 2; MAT-II; MAT 2; MATA2; Methionine adenosyltransferase II; S-AdenosylMethionine Synthase Isoform Type-2; Testicular Tissue Protein Li 121; MATII; S-Adenosylmethio
Species:
Human
Source:
E. coli
Cat. No.: HY-P704777
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAT2A; Methionine adenosyltransferase 2; Methionine adenosyltransferase 2A; AdoMet Synthase 2; MAT-II; MAT 2; MATA2; Methionine adenosyltransferase II; S-AdenosylMethionine Synthase Isoform Type-2; Testicular Tissue Protein Li 121; MATII; S-Adenosylmethio
Species:
Human
Source:
E. coli
Cat. No.: HY-155148
Research Areas:
MAT2A Allosteric inhibitor 1 (compound 5) is a MAT2A selective inhibitor of methionine adenosyltransferase (MAT) with an IC50 of 6.8 nM .
Cat. No.: HY-107778R
CAS No.: 72882-78-1
Research Areas:
PF-9366 (Standard) is the analytical standard of PF-9366 (HY-107778). This product is intended for research and analytical applications. PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
