Search Result
Results for "
Mushroom
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-161289
-
|
Tyrosinase
|
Cancer
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Tyrosinase-IN-24 (compound 3b) is a tyrosinase inhibitor with inhibitory activity against mushroom tyrosinase .
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- HY-N10286
-
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Tyrosinase
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Others
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Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC50 of 31.7 μM .
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-
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- HY-114866
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Lentinacin; D-Eritadenine; Lentysine
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Biochemical Assay Reagents
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Cardiovascular Disease
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Eritadenine (Lentinacin) is a S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor. Eritadenine can be found in secondary metabolites of shiitake mushrooms. Eritadenine lowers blood cholesterol levels and can be used in cardiovascular disease research .
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- HY-N10285
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Tyrosinase
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Infection
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Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC50 value of 33.2 μM .
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- HY-122933
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-
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- HY-N7135
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Tyrosinase
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Others
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Tropolone is a Tropone derivative with a hydroxyl group at the 2-position, and is the precursor of many Azulene derivatives, such as 2-methylazulene-1-carboxylate. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU 2+ Reversal .
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- HY-N6653
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Others
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Cancer
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Lentinan is purified β-glucan from Shiitake mushrooms. Lentinan has been approved as a biological response modifier for gastric cancer in Japan .
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-
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- HY-W013571
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Fungal
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Infection
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4-Isopropylbenzoic acid, an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase .
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- HY-125860
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Polyphenol oxidase
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Tyrosinase
|
Metabolic Disease
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Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin and is encoded by TYR gene. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes .
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- HY-125586
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DNA/RNA Synthesis
ADC Cytotoxin
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Cancer
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β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .
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- HY-131081
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DNA/RNA Synthesis
ADC Cytotoxin
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Cancer
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γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL .
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- HY-P0096
-
|
Tyrosinase
Sirtuin
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Inflammation/Immunology
Endocrinology
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Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .
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- HY-P2031
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Arp2/3 Complex
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Others
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Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .
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- HY-N9527
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Others
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Others
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Poricoic acid BM is a lanostane triterpenoid that can be found in from peels of the mushroom Wolfiporia cocos .
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- HY-N10287
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Tyrosinase
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Infection
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Leptosin D, a thiodiketopiperazine alkaloid, is a mushroom tyrosinase inhibitor, with an IC50 of 28.4 μM .
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- HY-P0028
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Fluorescent Dye
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Others
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Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome
.
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- HY-131327
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Tyrosinase
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Cancer
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Azo-resveratrol, an Azo compound, inhibits Mushroom tyrosinase (IC50=36.28 μM).
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- HY-N9271
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Apoptosis
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Cancer
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Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces apoptosis .
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- HY-N11647
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Others
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Others
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Ganoderic acid Z is a ganoderic acid. Ganoderic acid Z, the lanostane triterpenoid, can be isolated from mushrooms of the genus Ganoderma .
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- HY-149157
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Others
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Metabolic Disease
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L-Lysine orotate is a salt of L-lysine and orotic acid that can potentiate the toxicity of an extract of the mushroom Amanita phalloides .
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- HY-N12810
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Tyrosinase
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Others
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Sanggenon O is a mushroom tyrosinase inhibitor that can be isolated from Morus nigra, with an IC50 value is 1.15 μM.
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-
- HY-19610
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α-Amanitin
Maximum Cited Publications
33 Publications Verification
α-Amatoxin
|
DNA/RNA Synthesis
ADC Cytotoxin
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Cancer
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α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
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- HY-131083
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-
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- HY-N3266
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Tyrosinase
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Cancer
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Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase, and also inhibits a-glucosidase .
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- HY-117761
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PPAR
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Metabolic Disease
Cancer
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MHY908 is a potent dual agonist of PPARα and PPARγ . MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity .
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- HY-N3977
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- HY-122493
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities .
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- HY-N7842
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17-Methylstearic acid; 17-Methyloctadecanoic acid
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Biochemical Assay Reagents
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Others
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17-Methylstearic acid is a methyl-branched fatty acid that has been found in mouse meibomian glands, C. cornucopioides mushrooms, and Phytobacter species. It is also found in the aerial parts of C. ladanifer, where its concentration varies seasonally.
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- HY-111954
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Erinacine A
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Others
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Neurological Disease
Cancer
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(+)-Erinacin A is an anticancer compound that can be isolated from the mushroom Hericium erinaceum. (+)-Erinacin A has the capacity to trigger cancer cell death dependent on the production of reactive oxygen species (ROS). (+)-Erinacin A has anticancer and neuroprotective activity .
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-
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- HY-W015616
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4-Penylbutan-2-one
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Tyrosinase
|
Metabolic Disease
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Benzylacetone is an aromatic compound from agarwood . Benzylacetone exhibits potent and reversible antityrosinase (mushroom) activity, with IC50s of 2.8 mM and 0.6 mM for monophenolase and diphenolase, respectively . Benzylacetone has appetite-enhancing and locomotor-reducing effects .
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- HY-N10219
-
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Tyrosinase
Fungal
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Infection
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Dihydroaltenuene B is a potent mushroom tyrosinase inhibitor with an IC50 of 38.33 µM. Dihydroaltenuene B shows the hydrogen bonding interactions between the 3-OH and 4’-OH and the His244, Met280 and Gly281 residues of tyrosinase .
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- HY-N7302
-
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Others
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Cancer
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Anthracophyllone is an aristolane sesquiterpene that can be isolated from the mushroom Anthracophyllum. Anthracophyllone has cytotoxicity against MCF-7, KB, NCI-H187, Vero cells (IC50: 32.97, 18.02, 15.17, 18.06 μM) .
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-
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- HY-N2101
-
|
Tyrosinase
NF-κB
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Inflammation/Immunology
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Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .
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- HY-N2006
-
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EBV
HIV Protease
|
Infection
Inflammation/Immunology
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Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM) .
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-
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- HY-N11893
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(R)-Aloesinol
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Others
|
Others
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8-C-Glucosyl-(R)-aloesol ((R)-Aloesinol) is a bioactive chromone analogue .
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- HY-19893
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(+)-Antroquinonol
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Keap1-Nrf2
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Inflammation/Immunology
Cancer
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Antroquinonol ((+)-Antroquinonol), a ubiquinone derivative from the mushroom Antrodia camphorata, has hepatoprotective, anti-inflammatory, and anti-cancer effects . Antroquinonol can be used for the research of colon cancer . Antroquinonol reduces oxidative stress by enhancing the Nrf2 signaling pathway and inhibits inflammation and sclerosis in focal segmental glomerulosclerosis mice .
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- HY-118341
-
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Apoptosis
Bcl-2 Family
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Cancer
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Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .
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-
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- HY-N9283
-
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Reactive Oxygen Species
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Neurological Disease
Cancer
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1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran, isolated from the edible mushroom Sarcodon leucopus, has antioxidant effects in the DPPH scavenging assay with the IC50 of 28 μM, inhibits malondialdehyde (MDA) with the IC50 of 71 μM, and inhibits α-glucosidase with the IC50 of 6.22 μM .
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- HY-N1430
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trans-Oxyresveratrol
|
Tyrosinase
HSV
Autophagy
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Others
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Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .
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- HY-N0619
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TNF Receptor
Interleukin Related
Tyrosinase
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Inflammation/Immunology
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Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
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- HY-N3773
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Tyrosinase
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Cancer
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Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .
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- HY-N0619A
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Mulberroside D
|
TNF Receptor
Interleukin Related
Tyrosinase
|
Inflammation/Immunology
|
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
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- HY-N7175
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9,11-Dehydroergosterol peroxide; 9(11)-DHEP
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Apoptosis
Endogenous Metabolite
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Cancer
|
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis .
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- HY-151829
-
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ADC Linker
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Others
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Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II .
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-
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- HY-N9768
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9-oxo-ODA
|
Fungal
PPAR
|
Infection
|
(10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity .
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-
Cat. No. |
Product Name |
Type |
-
- HY-N7842
-
17-Methylstearic acid; 17-Methyloctadecanoic acid
|
Biochemical Assay Reagents
|
17-Methylstearic acid is a methyl-branched fatty acid that has been found in mouse meibomian glands, C. cornucopioides mushrooms, and Phytobacter species. It is also found in the aerial parts of C. ladanifer, where its concentration varies seasonally.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P2031
-
|
Arp2/3 Complex
|
Others
|
Phallacidin is a member of the phallotoxin family of mushroom toxins. Phallacidin binds F-actin .
|
-
- HY-P0028
-
|
Fluorescent Dye
|
Others
|
Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome
.
|
-
- HY-P0096
-
|
Tyrosinase
Sirtuin
|
Inflammation/Immunology
Endocrinology
|
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 µM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .
|
-
- HY-125357
-
|
Peptides
|
Metabolic Disease
|
Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC50 of 0.027 μM in 3T3-L1 adipocytes .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N7135
-
-
-
- HY-N6653
-
-
-
- HY-N10286
-
-
-
- HY-N10285
-
-
-
- HY-122933
-
-
-
- HY-W013571
-
-
-
- HY-131081
-
-
-
- HY-P2031
-
-
-
- HY-N9527
-
-
-
- HY-N10287
-
-
-
- HY-N9271
-
-
-
- HY-N11647
-
-
-
- HY-N12810
-
-
-
- HY-131083
-
-
-
- HY-N3266
-
-
-
- HY-N3977
-
-
-
- HY-122493
-
-
-
- HY-111954
-
Erinacine A
|
Structural Classification
Microorganisms
Terpenoids
Diterpenoids
|
Others
|
(+)-Erinacin A is an anticancer compound that can be isolated from the mushroom Hericium erinaceum. (+)-Erinacin A has the capacity to trigger cancer cell death dependent on the production of reactive oxygen species (ROS). (+)-Erinacin A has anticancer and neuroprotective activity .
|
-
-
- HY-W015616
-
-
-
- HY-N10219
-
-
-
- HY-N7302
-
-
-
- HY-N2101
-
-
-
- HY-N2006
-
-
-
- HY-N11893
-
-
-
- HY-118341
-
-
-
- HY-N9283
-
|
Microorganisms
Source classification
Phenols
Polyphenols
|
Reactive Oxygen Species
|
1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran, isolated from the edible mushroom Sarcodon leucopus, has antioxidant effects in the DPPH scavenging assay with the IC50 of 28 μM, inhibits malondialdehyde (MDA) with the IC50 of 71 μM, and inhibits α-glucosidase with the IC50 of 6.22 μM .
|
-
-
- HY-N1430
-
-
-
- HY-N0619
-
-
-
- HY-N3773
-
-
-
- HY-N0619A
-
-
-
- HY-N7175
-
9,11-Dehydroergosterol peroxide; 9(11)-DHEP
|
Classification of Application Fields
Source classification
Solanum lyratum Thunberg
Plants
Solanaceae
Disease Research Fields
Steroids
Cancer
|
Apoptosis
Endogenous Metabolite
|
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis .
|
-
-
- HY-N9768
-
9-oxo-ODA
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Fungal
PPAR
|
(10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity .
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-151829
-
|
|
Azide
|
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II .
|
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