2 Results for "

NCI-H345 cells

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "NCI-H345 cells" in MCE Product Catalog:

Cat. No.: HY-111918
CAS No.: 127902-33-4
Research Areas:  

Metabolic Disease

A71378 is a selectivity CCK-A receptor agonist the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC50 = 0.16 nM) and ileal muscle contraction (EC50 = 3.7 nM) .
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Cat. No.: HY-P2055
CAS No.: 125598-87-0
Target:  

Endogenous Metabolite

Research Areas:  

Endocrinology

A-57696 is a cholecystokinin antagonist with selective activity at cortical CCK-B receptors (IC50 = 25 nM). A-57696 behaves as a competitive antagonist in reversing CCK8-stimulated pancreatic alpha-amylase secretion and phosphatidylinositol degradation. A-57696 fails to induce gallbladder contraction and inhibits CCK8-induced contraction. A-57696 behaves as a partial agonist at CCK-B/gastrin receptors on NCI-H345 cells, achieving 80% of the maximal CCK8 response. A-57696 and CCK8 inhibit each other in a calcium mobilization assay .
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