Search Result

Results for "

NET

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (20) Adrenergic Receptor (15) Akt (4) Aminotransferases (Transaminases) (1) Antifolate (1) Apoptosis (9) Bacterial (1) Biochemical Assay Reagents (2) Bradykinin Receptor (3) Calcium Channel (4) Caspase (2) CDK (1) Complement System (1) Dihydrofolate reductase (DHFR) (1) Dopamine Receptor (3) Dopamine Transporter (15) Drug Derivative (4) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (2) Endogenous Metabolite (1) Environmental Pollutants (2) FGFR (2) Glutaminase (1) GPR109A (1) HCN Channel (2) Histamine Receptor (5) Histone Methyltransferase (2) iGluR (2) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (8) mAChR (5) MDM-2/p53 (2) MMP (1) Monoamine Transporter (19) mTOR (4) NADPH Oxidase (1) NF-κB (1) P-glycoprotein (4) p38 MAPK (2) PAK (1) PI3K (4) Potassium Channel (4) Prostaglandin Receptor (3) Protein Arginine Deiminase (3) Pyroptosis (1) Radionuclide-Drug Conjugates (RDCs) (3) RAR/RXR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (10) ROCK (4) Serotonin Transporter (36) Sigma Receptor (2) Small Interfering RNA (siRNA) (10) Sodium Channel (9) Somatostatin Receptor (2) Survivin (1) TGF-β Receptor (2) Trk Receptor (9) Vasopressin Receptor (2) VEGFR (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (15) Endocrinology (13) Infection (1) Inflammation/Immunology (19) Metabolic Disease (7) Neurological Disease (73)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (4) siRNAs (10)

118

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14258

Escitalopram 10+ Cited Publications (S)-Citalopram; (S)-(+)-Citalopram	Serotonin Transporter	Neurological Disease
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-122218

JHU-083 5+ Cited Publications	Glutaminase	Neurological Disease
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b ⁺ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals .

HY-14258A

Escitalopram oxalate 10+ Cited Publications (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate	Serotonin Transporter	Neurological Disease Cancer
Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-111674

LDC7559 Maximum Cited Publications 22 Publications Verification	Pyroptosis	Inflammation/Immunology
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages .

HY-W614269

DOTA-GA(tBu)4	Radionuclide-Drug Conjugates (RDCs)	Cancer
DOTA-GA(tBu)4 stabilizes the attachment of radiometals to ligands. DOTA-GA(tBu)4 improves the biodistribution of radiolabeled second-generation Affibody molecules by increasing their net negative charge and reducing hepatic uptake, leading to enhanced tumor-to-blood and tumor-to-liver ratios. DOTA-GA(tBu)4 targets HER2>-expressing breast and gastrointestinal cancer .

HY-12798

Netarsudil 1 Publications Verification AR-13324	Monoamine Transporter ROCK	Cardiovascular Disease Neurological Disease
Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil is mainly used in the study of ocular hypertension and primary open-angle glaucoma .

HY-W052508

Norquetiapine 1 Publications Verification N-Desalkylquetiapine	Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter	Neurological Disease
Norquetiapine ( N-Desalkylauetiapine), a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation .

HY-12798B

Netarsudil hydrochloride 1 Publications Verification AR-13324 hydrochloride	ROCK	Cardiovascular Disease Neurological Disease
Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil hydrochloride reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma .

HY-P5126

DOTA-LM3 2 Publications Verification	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis . DOTA-LM3 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-W380450

Viloxazine Viloxazin; Emovit	5-HT Receptor	Neurological Disease
Viloxazine is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC₅₀= 0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (K_i=4.2 μM) and agonizes 5-HT2C receptors (EC₅₀= 32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD) .

HY-125784

Viloxazine hydrochloride Viloxazin hydrochloride; Emovit hydrochloride	5-HT Receptor	Neurological Disease
Viloxazine hydrochloride is a non-brain-penetrant, selective norepinephrine transporter (NET) inhibitor (IC₅₀=0.26 μM) and 5-HT receptor modulator. Viloxazine antagonizes 5-HT2B receptors (K_i=4.2 μM) and agonizes 5-HT2C receptors (EC₅₀=32 μM), respectively, and enhances 5-HT neurotransmission by modulating 5-HT2B/C receptors. Viloxazine also competitively inhibits NET from increasing NE and DA levels in the synaptic cleft, and can be used in the study of attention deficit hyperactivity disorder (ADHD) .

HY-B1704

Nisoxetine 1 Publications Verification	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

HY-19907

Liafensine BMS-820836	Dopamine Transporter Monoamine Transporter Serotonin Transporter	Neurological Disease
Liafensine (BMS-820836) is an orally active, blood-brain barrier-permeable monoamine reuptake inhibitor, with an IC₅₀ of 5.67 nM against DAT, 1.08 nM against SERT, and 7.99 nM against *NET. Liafensine binds to DAT* to block dopamine reuptake. Liafensine binds to SERT to block serotonin reuptake. Liafensine binds to *NET* to block norepinephrine reuptake. Liafensine can be used in studies related to depression .

HY-12798A

Netarsudil dimesylate 1 Publications Verification AR-13324 dimesylate	ROCK	Cardiovascular Disease Neurological Disease
Netarsudil (AR-13324) dimesylate is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil dimesylate reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil dimesylate is mainly used in the study of ocular hypertension and primary open-angle glaucoma .

HY-137655

BMS-P5	Protein Arginine Deiminase	Cancer
BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC₅₀ of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model .

HY-137655A

BMS-P5 free base	Protein Arginine Deiminase	Cancer
BMS-P5 free base is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC₅₀ of 98 nM. BMS-P5 free base shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 free base blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model .

HY-B1704A

Nisoxetine hydrochloride 1 Publications Verification	Monoamine Transporter Sodium Channel	Neurological Disease
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a K_d of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels .

HY-P5126A

DOTA-LM3 TFA 2 Publications Verification	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 TFA is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 TFA and 68 Ga-DOTA-LM3 TFA. 68 Ga-DOTA-LM3 TFA shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 TFA can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis . DOTA-LM3 (TFA) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-145237

BM213 3 Publications Verification	Complement System Apoptosis Reactive Oxygen Species (ROS)	Cancer
BM213 is a selective C5aR agonist, with an EC₅₀ of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury .

HY-B0168B

Levomilnacipran hydrochloride 1 Publications Verification (1S,2R)-Milnacipran hydrochloride; F-2695 hydrochloride	Serotonin Transporter Trk Receptor PI3K Akt mTOR P-glycoprotein	Neurological Disease Inflammation/Immunology
Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

HY-133116

4-Hydroxyatomoxetine	Adrenergic Receptor	Neurological Disease
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (K_i values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively) .

HY-W017448

Mepiquat chloride N,N-Dimethylpiperidinium chloride; PIX	Environmental Pollutants Biochemical Assay Reagents	Others
Mepiquat chloride (N,N-Dimethylpiperidinium chloride) is a systemic plant growth regulator. Mepiquat chloride reduces the activity of RuBP carboxylase. Mepiquat chloride decreases plant height, total length of vegetative and fruiting branches, and total leaf area of cotton. Mepiquat chloride reduces the net photosynthetic rate of cotton leaves. Mepiquat chloride promotes starch accumulation in cotton leaves without altering sucrose content .

HY-135615A

Desmethyl Sibutramine hydrochloride N-Desmethylsibutramine hydrochloride	Serotonin Transporter	Neurological Disease Metabolic Disease
Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant .

HY-14258AR

Escitalopram oxalate (Standard) (S)-Citalopram oxalate (Standard); (S)-(+)-Citalopram oxalate (Standard)	Reference Standards Serotonin Transporter	Neurological Disease Cancer
Escitalopram (oxalate) (Standard) is the analytical standard of Escitalopram (oxalate). This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-N12281

Sennoside	Apoptosis MDM-2/p53 PAK Calcium Channel	Endocrinology Cancer
Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna (Cassia angustifolia). Sennoside induces overexpression of wild-type p53 and p21/WAF as part of pathways mediating colonic epithelial cell apoptosis. Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli, and colorectal cancer .

HY-17590

Radafaxine hydrochloride 1 Publications Verification (S,S)-Hydroxybupropion hydrochloride; GW-353162A; BW-306U	Monoamine Transporter	Neurological Disease
Radafaxine hydrochloride (GW-353162A) is a DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

HY-135096

Amitriptyline-d3 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .

HY-103293A

Lys-Bradykinin TFA Kallidin (380-389) (human, porcine, bovine) TFA	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin (HY-103293). Lys-Bradykinin TFA is a ligand for kallidin and bradykinin receptor, which can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin TFA serves as a vasodilator, which widens blood vessels and increases blood flow. Lys-Bradykinin TFA stimulates net Na+ influx, and contributes to DNA synthesis. Lys-Bradykinin TFA involves in vascular regulation, inflammation and pain sensation .

HY-148866

*Cavα2δ1&NET-IN-3*	Calcium Channel	Neurological Disease Endocrinology
Cavα2δ1&NET-IN-3 (example 216) is an inhibitor of the subunit α2δ of voltage-gated calcium channels (VGCC) and noradrenaline transporter (NET). Cavα2δ1&NET-IN-3 has K_is of 100-500 nM for human α2δ-1 subunit of Ca_v2.2 calcium channel and NET, respectively .

HY-117777

GSK121	Protein Arginine Deiminase	Inflammation/Immunology Cancer
GSK121 is a selective PAD4 inhibitor. GSK121 can be used in the research of PAD4-related diseases, including those characterized by abnormal NET levels and various tumors .

HY-W040555

Norquetiapine dihydrochloride 1 Publications Verification N-Desalkylquetiapine dihydrochloride	Drug Metabolite 5-HT Receptor HCN Channel Serotonin Transporter	Neurological Disease
Norquetiapine ( N-Desalkylauetiapine) dihydrochloride, a metabolite of Quetiapine (HY-14544), is a selective HCN1 channel inhibitor, with an IC₅₀ of 13.9 μM. Norquetiapine dihydrochloride selectively inhibits noradrenaline reuptake, is a partial 5-HT_1A (K_i = 45 nM) receptor agonist, and acts as an antagonist at presynapticα2 (K_i = 237 nM), 5-HT_2C(K_i = 107 nM), and 5-HT₇ (K_i = 76 nM) receptors. Norquetiapine dihydrochloride blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine dihydrochloride shows partial anti-inflammatory effects in LPS (HY-D1056) injected C57BL/6 mice. Norquetiapine dihydrochloride can be used for the study of depression and inflammation .

HY-W703376

2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride	Serotonin Transporter Monoamine Transporter Dopamine Transporter	Neurological Disease
2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride (Compound Imp.1) is a non-selective monoamine transporter (DAT/NET/SERT) agonist. tert-Butylcathinone hydrochloride is promising for research of depressive disorders .

HY-148863

*Cavα2δ1&NET-IN-2*	Calcium Channel Monoamine Transporter	Inflammation/Immunology
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Ca_vα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Ca_vα2δ-1 with a K_i of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a K_i of 59 nM and IC₅₀ of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain .

HY-14258AS

Escitalopram-d6 oxalate	Serotonin Transporter	Neurological Disease
Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-155437

NEt-iFQ	RAR/RXR	Others
NEt-iFQ is a fluorescent retinoid X receptor (RXR) agonist with potent solvatochromic properties. NEt-iFQ selectively binds to RXR-LBP and fluoresces .

HY-129040

m-Iodobenzylguanidine 1 Publications Verification MIBG; Iobenguane	Monoamine Transporter	Neurological Disease Endocrinology Cancer
m-Iodobenzylguanidine (Iobenguane) is a ligand with high affinity against norepinephrine transporter (NET). m-Iodobenzylguanidine is used as an imaging agent in the diagnostic imaging and radionuclide studies of neuroendocrine tumors, such as neuroblastoma, pheochromocytoma and carcinoid tumor .

HY-178907

SERT/5-HT-IN-1	Serotonin Transporter 5-HT Receptor	Neurological Disease
SERT/5-HT-IN-1 (compound D17) is an orally active and potent dual target inhibitor of SERT/5-HT3A (SERT IC₅₀ = 1.5 nM, *NET* IC₅₀ = 49 nM, DAT IC₅₀ = 91 nM, 5-HT3A K_i = 12 nM). SERT/5-HT-IN-1 has an IC₅₀ of 39 nM to 5-HT3A. SERT/5-HT-IN-1 has a lower risk of liver, kidney, and cardiac toxicity. SERT/5-HT-IN-1 can be used for research on depressive disorders .

HY-107128

Ampreloxetine hydrochloride TD-9855 hydrochloride	Serotonin Transporter	Neurological Disease
Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC₅₀ values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .

HY-172421

Cendifensine	Monoamine Transporter Serotonin Transporter Dopamine Transporter	Neurological Disease
Cendifensine is the inhibitor for monoamine reuptake that inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) .

HY-W354635

N-Methyl-2-phenylpropan-1-amine hydrochloride	Dopamine Transporter Monoamine Transporter	Neurological Disease
N-Methyl-2-phenylpropan-1-amine hydrochloride is a β-Methylphenethylamine (BMPEA) analog, and has transmitter releasing action at NET and DAT assay .

HY-B0457S

Clomipramine-d3 hydrochloride Chlorimipramine-d3 hydrochloride; G-34586-d3 hydrochloride; NSC-169865-d3 hydrochloride	Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d₃ (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-B0457AS

Clomipramine-d3 Chlorimipramine-d₃; G-34586-d₃; NSC-169865-d₃	Isotope-Labeled Compounds Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-B1308

Adrenalone hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC₅₀ of 36.9 μM .

HY-B1308A

Adrenalone	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone is an inhibitor of dopamine β oxidase. Adrenalone is chemically similar to known norepinephrine transporter (NET) ligands with an IC₅₀ of 36.9 μM .

HY-148862

*Cavα2δ1&NET-IN-1*	Calcium Channel Monoamine Transporter	Inflammation/Immunology
Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Ca_vα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Ca_vα2δ-1 with a K_i of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a K_i of 383 nM and IC₅₀ of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain .

HY-103293

Lys-Bradykinin Kallidin (380-389) (human, porcine, bovine)	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation .

HY-14258AS1

Escitalopram-d4 oxalate (S)-Citalopram-d4 oxalate; (S)-(+)-Citalopram-d4 oxalate	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-18332B

DOV-102,677	Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC₅₀ = 129 nM; K_i = 222 nM), norepinephrine (NET) (IC₅₀ = 103 nM; K_i = 1030 nM), and serotonin (SERT) (IC₅₀ = 133 nM; K_i = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression .

HY-16525

XEN-2174	Monoamine Transporter Adrenergic Receptor	Neurological Disease
XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research .

HY-14794A

Levomilnacipran (1S,2R)-Milnacipran; F2695	Serotonin Transporter Trk Receptor PI3K mTOR P-glycoprotein Akt	Neurological Disease Inflammation/Immunology
Levomilnacipran ((1S,2R)-Milnacipran) is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

Cat. No.	Product Name

HY-L906

Norepinephrine Transporter (NET) Compound Library

647 compounds

On May 15, 2024, "Dimerization and antidepressant recognition at noradrenaline transporter" was published online by Nature. The research findings were an effort from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. This study unraveled the important neural system target - the noradrenaline transporter (NET), obtaining the binding modes of human NET homodimers with the natural substrate norepinephrine (NE) and six selective antidepressants. It laid an important theoretical foundation for understanding the physiological regulation mechanisms of NET and other monoamine transporters.

The Norepinephrine Transporter (NET) Compound Library is obtained by computer-aided virtual screening based on the HY-L901 compound library . The specific screening process includes molecular docking screening, key pharmacophore screening, and CNS-MPO screening, which can be used for new drug discovery targeting the noradrenaline transporter.

HY-L058

Glycolysis Compound Library

1,245 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,245 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Cat. No.	Product Name	Type

HY-W017448

Mepiquat chloride

N,N-Dimethylpiperidinium chloride; PIX

Biochemical Assay Reagents

Mepiquat chloride (N,N-Dimethylpiperidinium chloride) is a systemic plant growth regulator. Mepiquat chloride reduces the activity of RuBP carboxylase. Mepiquat chloride decreases plant height, total length of vegetative and fruiting branches, and total leaf area of cotton. Mepiquat chloride reduces the net photosynthetic rate of cotton leaves. Mepiquat chloride promotes starch accumulation in cotton leaves without altering sucrose content .

Cat. No.	Product Name	Target	Research Area

HY-P5126

DOTA-LM3 2 Publications Verification	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 and 68 Ga-DOTA-LM3. 68 Ga-DOTA-LM3 shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis . DOTA-LM3 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P5126A

DOTA-LM3 TFA 2 Publications Verification	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. LM3 refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, as well as a somatostatin antagonist. DOTA-LM3 TFA is often isotopically labeled for tracing tumors in vivo, such as 177Lu-DOTA-LM3 TFA and 68 Ga-DOTA-LM3 TFA. 68 Ga-DOTA-LM3 TFA shows favorable biodistribution, high tumor uptake, good tumor retention, and few safety concerns. 177Lu-DOTA-LM3 TFA can be used for research in DOTATOC-negative liver metastases, such as pancreatic NET and extensive tumor thrombosis . DOTA-LM3 (TFA) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-145237

BM213 3 Publications Verification	Complement System Apoptosis Reactive Oxygen Species (ROS)	Cancer
BM213 is a selective C5aR agonist, with an EC₅₀ of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury .

HY-103293A

Lys-Bradykinin TFA Kallidin (380-389) (human, porcine, bovine) TFA	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin (HY-103293). Lys-Bradykinin TFA is a ligand for kallidin and bradykinin receptor, which can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin TFA serves as a vasodilator, which widens blood vessels and increases blood flow. Lys-Bradykinin TFA stimulates net Na+ influx, and contributes to DNA synthesis. Lys-Bradykinin TFA involves in vascular regulation, inflammation and pain sensation .

HY-103293

Lys-Bradykinin Kallidin (380-389) (human, porcine, bovine)	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation .

HY-16525

XEN-2174	Monoamine Transporter Adrenergic Receptor	Neurological Disease
XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research .

HY-P1809A

Velmupressin acetate c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NET2 acetate	Vasopressin Receptor	Metabolic Disease
Velmupressin (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2) acetate is a potent, selective and short-acting peptidic V₂ receptor (V₂R) agonist with EC₅₀s of 0.07 and 0.02 nM for hV₂R and rV₂R, respectively .

HY-P1809

Velmupressin c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NET2	Vasopressin Receptor	Metabolic Disease
Velmupressin (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2) is a potent, selective and short-acting peptidic V₂ receptor (V₂R) agonist with EC₅₀s of 0.07 and 0.02 nM for hV₂R and rV₂R, respectively .

HY-P4139

activable cell-penetrating peptide (ACCP)	Peptides	Others
activable cell-penetrating peptide (ACCP) consists of a polycationic CPP (typically arg9 or r9) connected via a cleavable linker to a matching polyanion (typically glu9 or e9), which reduces the net charge to nearly zero and thereby inhibits adhesion and uptake into cells .

HY-103293B

Lys-Bradykinin tetraacetate Kallidin (380-389) (human, porcine, bovine) tetraacetate	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation .

HY-P11657

GN-2 peptoid	Bacterial	Infection
GN-2 peptoid is a 9-mer cationic amphipathic peptoid and bactericidal agent with an overall net charge of +4, broad-spectrum antimicrobial activity, and low hemolytic and cytotoxic activity against mammalian cells. GN-2 peptoid exerts bactericidal action against Escherichia coli in a concentration-dependent manner. GN-2 peptoid exhibits antimicrobial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa strains. GN-2 peptoid shows low toxicity against human red blood cells and HeLa cells. GN-2 peptoid maintains antimicrobial activity in the presence of 50% human blood plasma. GN-2 peptoid can be used for the research of bacterial infections .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14258

Escitalopram 10+ Cited Publications (S)-Citalopram; (S)-(+)-Citalopram	Natural Products Endogenous metabolite Source Classification	Serotonin Transporter
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-N12281

Sennoside	Quinones Structural Classification Leguminosae Anthraquinones Plants Senna alexandrina Milll Source Classification	Apoptosis MDM-2/p53 PAK Calcium Channel
Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna (Cassia angustifolia). Sennoside induces overexpression of wild-type p53 and p21/WAF as part of pathways mediating colonic epithelial cell apoptosis. Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli, and colorectal cancer .

HY-N7506

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Structural Classification Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Source Classification	Monoamine Transporter Dopamine Transporter
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀ = 0.58 μM) and norepinephrine transporter (NET) (IC₅₀ = 0.69 μM) than for the serotonin transporter (SERT) (IC₅₀ = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression .

HY-122405

Quebrachidine	Apocynaceae Alkaloids Other Alkaloids Plants Source Classification Alstonia constricta F.Muell.	Others
Quebrachidine is an indole alkaloid that exhibits antiarrhythmic profile. Quebrachidine also demonstrates a net positive inotropic action on cardiac tissues .

HY-14258R

Escitalopram (Standard) (S)-Citalopram (Standard); (S)-(+)-Citalopram (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Serotonin Transporter Reference Standards
Escitalopram (Standard) is the analytical standard of Escitalopram. This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

Species:	Human (9) Rhesus Macaque (2) Mouse (2)
Tag:	SUMO (1) His (8) Tag Free (1) Myc (1) GST (2) Fc (4)
Source:	HEK293 (8) Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75748

	EphB1 Protein, Mouse (HEK293, His) 1 Publications Verification Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6	Mouse	HEK293
	EphB1 protein is a receptor tyrosine kinase that participates in bidirectional signaling with ephrin B ligands (including EFNB1, EFNB2, and EFNB3). It plays a crucial role in retinal axon guidance, neural progenitor cell regulation, dendritic spine maturation, synapse formation, angiogenesis, targeted cell migration, and muscle stem cell maintenance. EphB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77360

	EphB1 Protein, Rhesus Macaque (HEK293, His) Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6	Rhesus Macaque	HEK293
	EphB1, a tyrosine kinase receptor, was promiscuously bound to the transmembrane ligand ephrin-B family on adjacent cells, initiating contact-dependent bidirectional signaling. EphB1 activates the MAPK/ERK and JNK signaling cascades that regulate cell migration and adhesion, respectively. EphB1 promotes differentiation and maturation of dendritic cells in non-small cell lung cancer. EphB1 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived EphB1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77359

	EphB1 Protein, Rhesus Macaque (HEK293, Fc) Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6	Rhesus Macaque	HEK293
	EphB1, a tyrosine kinase receptor, was promiscuously bound to the transmembrane ligand ephrin-B family on adjacent cells, initiating contact-dependent bidirectional signaling. EphB1 activates the MAPK/ERK and JNK signaling cascades that regulate cell migration and adhesion, respectively. EphB1 promotes differentiation and maturation of dendritic cells in non-small cell lung cancer. EphB1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived EphB1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72998

	EphB1 Protein, Human (HEK293, His) Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6	Human	HEK293
	The EphB1 protein is a receptor tyrosine kinase that promiscuously binds to the transmembrane ephrin-B ligand of adjacent cells, initiating bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphB1 Protein, Human (HEK293, His) is the recombinant human-derived EphB1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75747

	EphB1 Protein, Mouse (Active, sf9, His-GST) Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6	Mouse	Sf9 insect cells
	EphB1 protein is a receptor tyrosine kinase that participates in bidirectional signaling with ephrin B ligands (including EFNB1, EFNB2, and EFNB3). It plays a crucial role in retinal axon guidance, neural progenitor cell regulation, dendritic spine maturation, synapse formation, angiogenesis, targeted cell migration, and muscle stem cell maintenance. EphB1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived EphB1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P72997

	EphB1 Protein, Human (Active, sf9, His-GST) Ephrin type-B receptor 1; ELK; EK6; NET; EPHB1; EPHT2; HEK6	Human	Sf9 insect cells
	The EphB1 protein is a receptor tyrosine kinase that promiscuously binds to the transmembrane ephrin-B ligand of adjacent cells, initiating bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphB1 Protein, Human (sf9, His-GST) is the recombinant human-derived EphB1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P70381

	EphB1 Protein, Human (HEK293, Fc) rHuEphrin type-B receptor 1/EphB1, Fc; Ephrin Type-B Receptor 1; ELK; EPH Tyrosine Kinase 2; EPH-Like Kinase 6; EK6; hEK6; Neuronally-Expressed EPH; Related Tyrosine Kinase; NET; Tyrosine-Protein Kinase Receptor EPH-2; EPHB1; ELK; EPHT2; HEK6	Human	HEK293
	The EphB1 protein is a receptor tyrosine kinase that promiscuously binds to the transmembrane ephrin-B ligand of adjacent cells, initiating bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphB1 Protein, Human (HEK293, Fc) is the recombinant human-derived EphB1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P702709

	EphB1 Protein, Human EPHB1; EPH receptor B1; EphB1 , EPHT2; ephrin type-B receptor 1; Hek6; EK6; EPH-like kinase 6; eph tyrosine kinase 2; soluble EPHB1 variant 1; tyrosine-protein kinase receptor EPH-2; neuronally-expressed EPH-related tyrosine kinase; ELK; NET; EPHT2; FLJ37986	Human	E. coli
	The EphB1 protein is a receptor tyrosine kinase that promiscuously binds to the transmembrane ephrin-B ligand of adjacent cells, initiating bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphB1 Protein, Human is the recombinant human-derived EphB1, expressed by E. coli, with tag-free. The total length of EphB1 Protein, Human is 295 a.a..

HY-P705819

	EphB1 Protein, Human (Active, sf9, His) rHuEphrin Type-B Receptor 1/Ephb1, His; Ephrin Type-B Receptor 1; ELK; EPH Tyrosine Kinase 2; EPH-Like Kinase 6; EK6; hEK6; Neuronally-Expressed EPH; Related Tyrosine Kinase; NET; Tyrosine-Protein Kinase Receptor EPH-2; EPHB1; ELK; EPHT2; HEK6	Human	E. coli

HY-P77260

	TSPAN1 Protein, Human (HEK293, His) Tetraspanin-1; Tspan-1; Tetraspan NET-1; Tetraspanin TM4-C	Human	HEK293
	TSPAN1 Protein is a member of the tetraspanin (TSPAN/TM4SF) family of proteins whose important feature is their ability to aggregate with one another or various other transmembrane receptors, to become TSPAN-enriched microdomains (TEMs). TSPAN1 functions as an oncoprotein in many cancer types, especially digestive malignancies such as hepatocellular carcinoma (HCC), pancreatic, gastric, colorectal, and esophageal cancers. TSPAN1 is a novel positive regulator of macroautophagy/autophagy characterized by decreased LC3-II and SQSTM1/p62 expressions, inhibited puncta formation of GFP-LC3 and autophagic vacuoles. TSPAN1 Protein, Human (HEK293, His) is the recombinant human-derived TSPAN1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P77261

	TSPAN1 Protein, Human (HEK293, rFc) Tetraspanin-1; Tspan-1; Tetraspan NET-1; Tetraspanin TM4-C	Human	HEK293
	TSPAN1 Protein is a member of the tetraspanin (TSPAN/TM4SF) family of proteins whose important feature is their ability to aggregate with one another or various other transmembrane receptors, to become TSPAN-enriched microdomains (TEMs). TSPAN1 functions as an oncoprotein in many cancer types, especially digestive malignancies such as hepatocellular carcinoma (HCC), pancreatic, gastric, colorectal, and esophageal cancers. TSPAN1 is a novel positive regulator of macroautophagy/autophagy characterized by decreased LC3-II and SQSTM1/p62 expressions, inhibited puncta formation of GFP-LC3 and autophagic vacuoles. TSPAN1 Protein, Human (HEK293, rFc) is the recombinant human-derived TSPAN1 protein, expressed by HEK293 , with N-rFc labeled tag.

HY-P77262

	TSPAN1 Protein, Human (HEK293, Fc) Tetraspanin-1; Tspan-1; Tetraspan NET-1; Tetraspanin TM4-C	Human	HEK293
	TSPAN1 Protein is a member of the tetraspanin (TSPAN/TM4SF) family of proteins whose important feature is their ability to aggregate with one another or various other transmembrane receptors, to become TSPAN-enriched microdomains (TEMs). TSPAN1 functions as an oncoprotein in many cancer types, especially digestive malignancies such as hepatocellular carcinoma (HCC), pancreatic, gastric, colorectal, and esophageal cancers. TSPAN1 is a novel positive regulator of macroautophagy/autophagy characterized by decreased LC3-II and SQSTM1/p62 expressions, inhibited puncta formation of GFP-LC3 and autophagic vacuoles. TSPAN1 Protein, Human (HEK293, Fc) is the recombinant human-derived TSPAN1 protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P71585

	KDM3B Protein, Human (Myc, His-SUMO) 5qNCA; C5orf7; JHDM2B; JmjC domain containing histone demethylation protein 2B; JmjC domain-containing histone demethylation protein 2B; jmjd1b; Jumonji domain containing 1B; Jumonji domain containing protein 1B; Jumonji domain-containing protein 1B; KDM3B; KDM3B_HUMAN; KIAA1082; Lysine (K) specific demethylase 3B ; Lysine-specific demethylase 3B; NET22; Nuclear protein 5qNCA	Human	E. coli
	KDM3B protein is a histone demethylase that mainly targets "Lys-9" of histone H3, catalyzes demethylation and produces formaldehyde and succinic acid by-products. In addition to histone modifications, KDM3B has been implicated in tumor suppressor activity, indicating its importance in cellular processes, gene expression regulation, and epigenetic modifications. KDM3B Protein, Human (Myc, His-SUMO) is the recombinant human-derived KDM3B protein, expressed by E. coli , with C-Myc, N-SUMO, N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ hydrochloride is the deuterium labeled Amitriptyline hydrochloride (HY-B0527A). Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (K_i = 3.45 nM) and NET (K_i = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with K_i = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (K_i = 11-24 nM), H1 receptors (K_i = 0.5-1.1 nM), adrenergic α1 receptors (K_i = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC₅₀ = 4.78 μM) and it has cardiotoxicity.

HY-14258AS

Escitalopram-d6 oxalate

Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-B0457S

Clomipramine-d3 hydrochloride
Clomipramine-d₃ (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-B0457AS

Clomipramine-d3
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-14258AS1

Escitalopram-d4 oxalate

Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-129934S

Latanoprost ethyl amide-d4

Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

HY-107370AS

(Rac)-Atomoxetine-d7 hydrochloride
(Rac)-Atomoxetine-d₇ (hydrochloride) is a deuterium labeled (Rac)-Atomoxetine hydrochloride. (Rac)-Atomoxetine hydrochloride is a racemic form of Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively) .

HY-17385S

Atomoxetine-d5 hydrochloride
Atomoxetine-d₅ (hydrochloride) is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively) .

HY-14794AS

Levomilnacipran-d10 hydrochloride

Levomilnacipran-d₁₀ ((1S,2R)-Milnacipran-d₁₀) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

HY-B0168BS

Levomilnacipran-d5 hydrochloride

Levomilnacipran-d5 ((1S,2R)-Milnacipran-d5) hydrochloride is deuterium labeled Levomilnacipran hydrochloride (HY-B0168B). Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC₅₀ values of 10.5 nM and 19.0 nM, and K_i values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression .

Host:	Mouse (8) Rabbit (15)
Reactivity:	Human (23) Rat (10) Mouse (9) Monkey (1)
Application:	WB FC ICC/IF (1) IHC-P (9) ICC/IF (14) IF-Tissue (1) IP (6) IHC-F (5) WB (22) FC (6) ELISA (1)
Isotype:	IgG (15) IgG1 (5) IgG2a (2)
Conjugation:	Non-conjugated (23)
Clonality:	Polyclonal (1) Monoclonal (13) Recombinant (8)
Modification:	Unmodified (14)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85145

	Ephrin Receptor B1 Antibody (YA4837) EPHB1; ELK; EPHT2; HEK6; NET; Ephrin type-B receptor 1; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EK6; hEK6; Neuronally-expressed EPH-related tyrosine kinase; NET; Tyrosine-protein kinase receptor EPH-2	WB, IHC-P, ICC/IF, ELISA	Human
	Ephrin Receptor B1 Antibody (YA4837) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Ephrin Receptor B1.

HY-P82431

	Ephrin Receptor B1 Antibody (YA2176) EPHB1; ELK; EPHT2; HEK6; NET; Ephrin type-B receptor 1; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EK6; hEK6; Neuronally-expressed EPH-related tyrosine kinase; NET; Tyrosine-protein kinase receptor EPH-2	WB, IP	Human, Mouse, Rat
	Ephrin Receptor B1 Antibody (YA2176) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ephrin Receptor B1.

HY-P82161

	SCAI Antibody (YA1906) NET40; C9orf126	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	SCAI Antibody (YA1906) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCAI.

HY-P88649

	ALG2 Antibody (YA8333) CDGIi; hALPG2; NET38	WB, FC	Human
	ALG2 Antibody (YA8333) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ALG2.

HY-P88783

	ELK3 Antibody (YA8467) ERP; NET; SAP-2; SAP2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	ELK3 Antibody (YA8467) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ELK3.

HY-P88455

	MCAT Antibody (YA8139) fabD; FASN2C; MCT; MT; NET62	WB, ICC/IF	Human
	MCAT Antibody (YA8139) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MCAT.

HY-P82161A

	SCAI Antibody (YA1906)(PBS only) NET40; C9orf126	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	SCAI Antibody (YA1906) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SCAI.

HY-P88649A

	ALG2 Antibody (YA8333)(PBS only) CDGIi; hALPG2; NET38	WB, FC	Human
	ALG2 Antibody (YA8333) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ALG2.

HY-P83191

	GlyT2 Antibody (YA2936) NET1; GLYT2; HKPX3; GLYT-2	WB	Human, Rat
	GlyT2 Antibody (YA2936) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GlyT2.

HY-P88783A

	ELK3 Antibody (YA8467)(PBS only) ERP; NET; SAP-2; SAP2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	ELK3 Antibody (YA8467) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ELK3.

HY-P88455A

	MCAT Antibody (YA8139)(PBS only) fabD; FASN2C; MCT; MT; NET62	WB, ICC/IF	Human
	MCAT Antibody (YA8139) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MCAT.

HY-P81850

	NAT10 Antibody (YA1595) ALP; hALP; N acetyltransferase like protein; NAT10; NET43	WB, ICC/IF, IP	Human, Rat
	NAT10 Antibody (YA1595) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NAT10.

HY-P83191A

	GlyT2 Antibody (YA2936)(PBS only) NET1; GLYT2; HKPX3; GLYT-2	WB	Human, Rat
	GlyT2 Antibody (YA2936) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GlyT2.

HY-P81850A

	NAT10 Antibody (YA1595)(PBS only) ALP; hALP; N acetyltransferase like protein; NAT10; NET43	WB, ICC/IF, IP	Human, Rat
	NAT10 Antibody (YA1595) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NAT10.

HY-P80940

	STING Antibody 1 Publications Verification ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-beta; Transmembrane Protein 173	WB	Human, Mouse
	STING Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to STING.

HY-P81269

	DBC 1 Antibody (YA955) DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
	DBC 1 Antibody (YA955) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DBC 1.

HY-P81269A

	DBC 1 Antibody (YA956) DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	DBC 1 Antibody (YA956) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DBC 1.

HY-P81626

	Nesprin3 Antibody (YA1371) KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341	WB	Human
	Nesprin3 Antibody (YA1371) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nesprin3.

HY-P81269AA

	DBC 1 Antibody (YA956)(PBS only) DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	DBC 1 Antibody (YA956) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DBC 1.

HY-P81626A

	Nesprin3 Antibody (YA1371)(PBS only) KASH3; NET53; Nesp3; C14orf49; C14orf139; LINC00341; NCRNA00341	WB	Human
	Nesprin3 Antibody (YA1371) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nesprin3.

HY-P810459

	Nesprin3 Antibody (YA9758) SYNE3, Spectrin Repeat Containing Nuclear Envelope Family Member 3, Nesprin-3, LINC00341, NET53, Long Intergenic Non-Protein Coding RNA 341, Nuclear Envelope Spectrin Repeat Protein 3, KASH Domain-Containing Protein 3, NCRNA00341, C14orf139, FLJ25605, C14orf49, Nesp3, KASH3, Chromosome 14 Open Reading Frame 139, Chromosome 14 Open Reading Frame 49, Uncharacterized Protein C14orf113, Non-Protein Coding RNA 341, C14ORF139, NESPRIN-3, C14ORF49, NESP3	WB FC ICC/IF	Human
	Nesprin3 Antibody (YA9758) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to Nesprin3.

HY-P86931

	KDM3B Antibody (YA6624) 5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; 5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; KDM3B_HUMAN antibody; KIAA1082 antibody; Lysine (K) specific demethylase 3B antibody; Lysine-specific demethylase 3B antibody; NET22 antibody; Nuclear protein 5qNCA antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse
	KDM3B Antibody (YA6624) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM3B.

HY-P86872

	Erlin-2 Antibody (YA6565) C8orf2 antibody; Chromosome 8 open reading frame 2 antibody; Endoplasmic reticulum lipid raft associated protein 2 antibody; Endoplasmic reticulum lipid raft-associated protein 2 antibody; ER lipid raft associated 2 antibody; ERLIN 2 antibody; Erlin-2 antibody; ERLIN2 antibody; ERLN2_HUMAN antibody; HGNC:1356 antibody; C8orf2 antibody; Chromosome 8 open reading frame 2 antibody; Endoplasmic reticulum lipid raft associated protein 2 antibody; Endoplasmic reticulum lipid raft-associated protein 2 antibody; ER lipid raft associated 2 antibody; ERLIN 2 antibody; Erlin-2 antibody; ERLIN2 antibody; ERLN2_HUMAN antibody; HGNC:1356 antibody; MGC87072 antibody; NET32 antibody; SPFH 2 antibody; SPFH domain containing protein 2 antibody; SPFH domain family member 2 antibody; SPFH domain-containing protein 2 antibody; SPFH2 antibody; SPG18 antibody; Stomatin prohibitin flotillin HflC/K domain containing protein 2 antibody; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 antibody;	WB, IHC-P, IHC-F, ICC/IF, FC, IF-Tissue	Human, Mouse
	Erlin-2 Antibody (YA6565) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Erlin-2.

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