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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
Netherton syndrome
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "Netherton syndrome" in MCE Product Catalog:
Cat. No.: HY-148949A
Purity: 99.53%
Target:
Research Areas:
Kallikrein 5-IN-2 TFA is the TFA salt form of Kallikrein 5-IN-2 (HY-148949). Kallikrein 5-IN-2 TFA is a selective inhibitor for kallikrein 5 (KLK5) with pIC50 of 7.1. Kallikrein 5-IN-2 TFA is non-phototoxic (100 μg/mL) and non-irritant. Kallikrein 5-IN-2 is stable at pH 4-pH 8 under non-oxidative condition. Kallikrein 5-IN-2 is potent in ameliorating the Netherton syndrome .
Cat. No.: HY-P4669
CAS No.: 1122484-55-2
Synonyms: BPR277
Target:
Research Areas:
Cat. No.: HY-150085
CAS No.: 2393881-77-9
Target:
Research Areas:
GSK951 is a highly potent, selective, and reversibly covalent KLK5 inhibitor, with an IC50 of approximately 250 pM and a pIC50 of 9.6 against hKLK5. It exhibits over 100-fold selectivity over KLK7, KLK14, matriptase, and elastase. GSK951 binds to the catalytic site of KLK5 via covalent interaction with the catalytic serine, with a slow dissociation rate. GSK951 improves skin barrier function, reduces transepidermal water loss, decreases the expression of proinflammatory cytokines, and inhibits the elevated KLK5 protease activity in the stratum corneum. GSK951 can be used in studies related to skin barrier dysfunction.
Cat. No.: HY-P11840
Research Areas:
Cat. No.: HY-100497
CAS No.: 1087624-28-9
Target:
Research Areas:
KLK5/14-IN-1 is a selective human skin kallikrein inhibitor with IC50 values of 0.048 μM, 0.2 μM, and 0.1 μM for KLK7, KLK5, and KLK14, respectively. KLK5/14-IN-1 shows no or only low inhibitory activity against Cathepsin G, Chymotrypsin, Trypsin, and Thrombin. KLK5/14-IN-1 can be used in research related to Netherton syndrome .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
