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Non-muscle myosin IIB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Myosin (3) Akt (2) ERK (2) Ferroptosis (2) mTOR (2) PDGFR (2) Reactive Oxygen Species (ROS) (2)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Neurological Disease (1)

Inhibitors & Agonists

Antibodies

Targets Recommended: Myosin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-174406

MT-125	Myosin PDGFR Reactive Oxygen Species (ROS) Ferroptosis Akt mTOR ERK	Cancer
MT-125 is a specific and well-tolerated inhibitor of non-muscle *myosin* IIA (K_i,NMIIA = 2.7 μM) and IIB (EC₅₀ = 1.7 μM). MT-125 can pass through the blood-brain barrier. MT-125 induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 can enhance the PDGFR signaling pathway. MT-125 can be used for research on glioblastoma.

HY-175188

MT-110 BPN-0027490	Myosin	Neurological Disease
MT-110 (BPN-0027490) is a non-muscle myosin NMIIB-selective inhibitor with high brain penetration and favorable safety profile. MT-110 specifically disrupts NMIIB-dependent actin dynamics in dendritic spines, while it exerts no significant adverse effects on cardiac myosin II and cardiac functions (such as cardiac output and heart rate) at tested concentrations. A single administration of MT-110 produces long-lasting (sustained for several weeks) blockade of methamphetamine motivation associated with environmental cues. MT-110 exhibits extremely high specificity, with no interference with cocaine motivation, hippocampus-dependent memory, fear memory, or locomotor and anxiety-like behaviors. MT-110 serves as a valuable tool compound for investigating the mechanisms of methamphetamine use disorder .

HY-174406A

MT-125 free base	Myosin PDGFR Reactive Oxygen Species (ROS) Ferroptosis Akt mTOR ERK	Inflammation/Immunology Cancer
MT-125 free base is a specific and well-tolerated inhibitor of non-muscle *myosin* IIA (K_i,NMIIA = 2.7 μM) and IIB (EC₅₀ = 1.7 μM). MT-125 free base can pass through the blood-brain barrier. MT-125 free base induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 free base can enhance the PDGFR signaling pathway. MT-125 free base can be used for research on glioblastoma.

Host:	Rabbit (2)
Reactivity:	Human (2) Mouse (2)
Application:	IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83369

	MYH10 Antibody (YA3114) NMMHCB; NMMHC-IIB; myosin-10, myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIB, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

HY-P83369A

	MYH10 Antibody (YA3114)(PBS only) NMMHCB; NMMHC-IIB; myosin-10, myosin heavy chain 10, Non-muscle myosin heavy chain B, Non-muscle myosin heavy chain IIB, NMMHC-B, NMMHC II-b, NMMHC-IIB, MYH10	WB, IP	Human, Mouse
	MYH10 Antibody (YA3114) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MYH10.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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