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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
P2Y Purinergic Receptor
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "P2Y Purinergic Receptor" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P87002
Synonyms: ADP glucose Receptor antibody; ADP-glucose Receptor antibody; ADPG R antibody; ADPG-R antibody; ADPGR antibody; BDPLT8 antibody; G protein coupled Receptor SP1999 antibody; Gi coupled ADP Receptor HORK 3 antibody; Gi coupled ADP Receptor HORK3 antibody; HORK 3 antibody; ADP glucose Receptor antibody; ADP-glucose Receptor antibody; ADPG R antibody; ADPG-R antibody; ADPGR antibody; BDPLT8 antibody; G protein coupled Receptor SP1999 antibody; Gi coupled ADP Receptor HORK 3 antibody; Gi coupled ADP Receptor HORK3 antibody; HORK 3 antibody; HORK3 antibody; P2RY 12 antibody; P2RY12 antibody; P2T(AC) antibody; P2Y 12 antibody; P2Y purinoceptor 12 antibody; P2Y(12)R antibody; P2Y(AC) antibody; P2Y(ADP) antibody; P2Y(cyc) antibody; P2Y12 antibody; P2Y12 platelet ADP Receptor antibody; P2Y12_HUMAN antibody; Platelet ADP Receptor antibody; Purinergic Receptor P2RY12 antibody; Purinergic Receptor P2Y G protein coupled 12 antibody; Purinergic Receptor P2Y12 antibody; Putative G protein coupled Receptor antibody; SP 1999 antibody; SP1999 antibody;
Synonyms: Adenosine 5'-β-thiodiphosphate trilithium
Target:
Research Areas:
ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .
Synonyms: 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium
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Research Areas:
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .
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Research Areas:
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7 .
Cat. No.: HY-173447
CAS No.: 344402-39-7
8-BuS-AMP is a NTPDase1 inhibitor and a CD73/CD39 inhibitor, with an IC50 of 35 μM and a Ki value of 0.292 μM against human NTPDase1; its Ki values against human CD73 and CD39 are 1.19 μM and 0.847 μM, respectively. 8-BuS-AMP binds to the substrate-binding pockets of NTPDase1 and CD73 to effectively block the conversion of ATP and AMP to adenosine, thereby enhancing the activation and proliferation of human peripheral T lymphocytes. 8-BuS-AMP possesses excellent enzymatic hydrolysis resistance and metabolic stability, resists hydrolysis by multiple NTPDase subtypes, and shows no activity against P2Y1 and P2Y12 receptors. 8-BuS-AMP can be used in purinergic signaling pathway and cancer-related studies .
Cat. No.: HY-137325A
CAS No.: 301334-89-4
Target:
Research Areas:
2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.
Cat. No.: HY-137418
CAS No.: 43170-89-4
Synonyms: 2-Methylthio-ATP
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Research Areas:
2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases .
Cat. No.: HY-134353A
Synonyms: Adenosine 5'-(β-thiodiphosphate) trisodium
Target:
Research Areas:
ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) trilithium is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S trilithium activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S trilithium activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S trilithium can be used in the research of diseases such as inflammation and diabetes .
Cat. No.: HY-137602
CAS No.: 26184-65-6
Synonyms: Up2U
Target:
Research Areas:
P1,P2-Diuridine-5’-diphosphate (Up2U) is a symmetrical dinucleoside polyphosphate containing two pyrimidine base moieties. P1,P2-Diuridine-5’-diphosphate is also an activator of purinergic P2Y receptor .
Cat. No.: HY-137749A
Synonyms: 2'-Deoxy-3'-MANT-ADP trisodium
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MANT-dADP (trisodium) (2'-Deoxy-3'-MANT-ADP (trisodium)) is a fluorescent nucleotide derivative, with an emission maximum of 453 nm upon excitation at 350 nm. MANT-dADP (trisodium) can decrease inositol phoshate formation in CHO-K1 cells that express human purinergic P2Y12 receptor. MANT-dADP (trisodium) can be studied in research on the interaction between cardiac troponin I and myofibrils .
Cat. No.: HY-137610A
Target:
Research Areas:
TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC50 = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED50 = 6.35 µmol/kg) [1][2].
Cat. No.: HY-P701629
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: P2RY1; P2Y Purinoceptor 1; Purinergic Receptor P2Y1; ADP Receptor; P2Y1; P2 Purinoceptor Subtype Y1; SARCC; Platelet ADP Receptor; Suppressing Androgen Receptor In Renal Cell Carcinoma; Purinergic Receptor; Purinergic Receptor P2Y, G-Protein Coupled, 1; A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701630
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: P2RY1; P2Y Purinoceptor 1; Purinergic Receptor P2Y1; ADP Receptor; P2Y1; P2 Purinoceptor Subtype Y1; SARCC; Platelet ADP Receptor; Suppressing Androgen Receptor In Renal Cell Carcinoma; Purinergic Receptor; Purinergic Receptor P2Y, G-Protein Coupled, 1; A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-137616C
Target:
Research Areas:
Rp-dUTPαS (tetrasodium) is an isomer of the sulfur-containing nucleoride dUTP-α-S and an agonist of the purinergic P2Y2 receptor. Rp-dUTPαS (tetrasodium) selectively induces inositol phosphate accumulation in P2Y2-expressing 1321N1 cells with an EC50 of 12.5 μM .
Cat. No.: HY-137612C
Synonyms: Rp-Uridine 5'-O-1-thiotriphosphate tetrasodium
Target:
Research Areas:
Rp-UTP-α-S (Rp-Uridine 5'-O-(1-thiotriphosphate)) tetrasodium is a nucleotide agonist of purinergic P2Y2 and P2Y4 receptors. Rp-UTP-α-S (tetrasodium) can induce inositol phosphate accumulation in P2Y2 or P2Y4 expressing 1321N1 cells with EC50 values of 5.4 and 27 μM .
Cat. No.: HY-P87437A
Synonyms: P2RU1, P2RY2, P2Y purinoceptor 2, P2Y2, ATP Receptor, P2U purinoceptor 1, P2U Receptor 1, Purinergic Receptor, P2U1
Cat. No.: HY-143890
CAS No.: 2801625-42-1
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MRS4738 is a human P2Y14-targeted inhibitor with an IC50 of 3.11 nM. MRS4738 suppresses inflammatory responses of pulmonary neutrophils and lymphocytes, reduces airway eosinophil accumulation, and alleviates mechanical hyperalgesia. MRS4738 can be applied to the research on the mechanisms of diseases associated with pulmonary inflammation, neuropathic pain and asthma .
Cat. No.: HY-P703107
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTB4R; P2Y Purinoceptor 7; Prev. CMKRL1; LTB4-R1; Prev. GPR16; BLT1; Prev. P2RY7; Purinergic Receptor P2Y, G-Protein Coupled, 7; BLTR; G Protein-Coupled Receptor 16; P2Y7; G-Protein Coupled Receptor 16; LTB4R1; Chemokine Receptor-Like 1; Chemoattractant R
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
