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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
PROTAC Nampt degrader
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "PROTAC Nampt degrader" in MCE Product Catalog:
PROTAC NAMPT Degrader-30 is a PROTAC degrader targeting nicotinamide phosphoribosyltransferase (NAMPT), with a DC50 of 8.4 nM in A2780 cells. PROTAC NAMPT Degrader-30 binds to the VHL E3 ligase and forms a ternary complex with NAMPT, which induces ubiquitination and subsequent proteasomal degradation of NAMPT, thereby inhibiting the enzymatic activity of NAMPT. PROTAC NAMPT Degrader-30 reduces intracellular NAD + levels and suppresses tumor cell proliferation. PROTAC NAMPT Degrader-30 exhibits a fluorescence turn-on response to the NAMPT protein, enabling real-time visualization of the NAMPT degradation process in living cells. PROTAC NAMPT Degrader-30 is applicable for research on ovarian cancer .
Cat. No.: HY-163440
CAS No.: 3102963-15-2
PROTAC NAMPT Degrader-1 is a potent PROTAC targeting NAMPT with aDC50 value of 217 nM. PROTAC NAMPT Degrader-1 has anti-proliferative activity with an IC50 value of 0.12μM against A2780 cells.
(Structure Note: PINK, NAMPT activator (HY-163445); Blue, VHL ligand (HY-163440); Black, linker) .
Cat. No.: HY-163445
CAS No.: 2237267-86-4
Research Areas:
NAMPT activator-6 is a nicotinamide phosphoribosyltransferase (NAMPT) activator. NAMPT activator-6 can be used for the synthesis of PROTACs, such as PROTAC NAMPT Degrader-1 (HY-163440). NAMPT activator-6 applies to the research of ovarian cancer .
Cat. No.: HY-159009
CAS No.: 1593654-46-6
Research Areas:
MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD + required for rapid proliferation. MS7, as a NAMPT target protein ligand, can be used to synthesize PROTAC A7, which is an effective NAMPT degrader. MS7 can be used in cancer research .
Cat. No.: HY-181880
PROTAC NAMPT Degrader-28 is a NAMPT PROTAC degrader with DC50 values of 45 nM and 55 nM in MCF7 and 4T1cl5 cells, respectively. PROTAC NAMPT Degrader-28 retains nicotinamide phosphoribosyltransferase inhibitory activity and does not induce degradation of this enzyme. PROTAC NAMPT Degrader-28 can be used in breast cancer-related research .
Cat. No.: HY-187347
PROTAC NAMPT Degrader-31 is a PROTAC degrader that targets and degrades NAMPT by recruiting cereblon. It exhibits DC50 values of 9.31 nM and 12.54 nM against NAMPT in MDA-MB-231 and 4T1 cells, respectively, and an IC50 value of 15.05 nM for NAMPT enzymatic activity. PROTAC NAMPT Degrader-31 induces NAMPT degradation via the ubiquitin-proteasome system, inhibits NAMPT enzymatic activity, and reduces NAD + levels through the NAD + salvage pathway. It can be used in research related to triple-negative breast cancer .
Cat. No.: HY-159016
CAS No.: 3094092-93-7
SIAIS630121-NC (compound 630121-NC) is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) PROTAC degrader SIAIS630121. SIAIS630121-NC shows no NAMPT degradation capability at all .
Cat. No.: HY-159015
SIAIS630120-NC is a negative control PROTAC compound synthesized using a methylated CRBN ligand, which serves as a control for SIAIS630120. SIAIS630120-NC lacks NAMPT degradation activity. SIAIS630120-NC exerts no cytotoxic effect on hematological tumor cells .
Cat. No.: HY-187006
CAS No.: 1110983-52-2
Research Areas:
Nampt-IN-21 is a NAMPT inhibitor. Nampt-IN-21 serves as a Ligand for Target Protein for PROTAC for the synthesis of PROTAC NAMPT degraders, such as PROTAC NAMPT Degrader-30 (HY-152154). Nampt-IN-21 is applicable to the research of ovarian cancer .
Cat. No.: HY-187348
CAS No.: 1800487-38-0
Research Areas:
TT-03597 is a modified NAMPT inhibitor core derived from OT-82 (HY-136241), which serves as a target protein ligand for PROTACs targeting NAMPT. TT-03597 can be used for the synthesis of PROTAC NAMPT Degrader-31 (HY-187347) .
Cat. No.: HY-181882
Research Areas:
MV78-OH-C7-COOH is a synthetic target protein ligand-linker conjugate that can be used for the synthesis of PROTACs, such as PROTAC NAMPT Degrader-28 (HY-181880) .
Cat. No.: HY-187380
Target:
Research Areas:
Pip-piperazine-CO-pip-CO-C2-Boc is a linker with a piperidine-piperazine-amide-piperidine scaffold and a succinyl group at the terminal, which can be used for the synthesis of PROTAC, such as PROTAC NAMPT Degrader-31 (HY-187347) .
Cat. No.: HY-187349
Research Areas:
E3 Ligase Ligand-linker Conjugate 241 is an E3 ligase ligand-linker conjugate that serves as a component of PROTAC, such as PROTAC NAMPT Degrader-31 (HY-187347). E3 Ligase Ligand-linker Conjugate 241 is applicable to research related to PROTAC synthesis .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
