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Cat. No.: HY-159016

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SIAIS630121-NC

SIAIS630121-NC (compound 630121-NC) is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) PROTAC degrader SIAIS630121. SIAIS630121-NC shows no NAMPT degradation capability at all.
(Pink: NAMPT ligand (HY-50876); Blue: Ligands for E3 Ligase ligand (HY-W597583); Black: linker (HY-159018)).

For research use only. We do not sell to patients.

CAS No.: 3094092-93-7
Formula: C₅₀H₆₁N₇O₅
Molecular Weight:840.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

SIAIS630121-NC Chemical Structure

CAS No.: 3094092-93-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SIAIS630121-NC (compound 630121-NC) is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) PROTAC degrader SIAIS630121. SIAIS630121-NC shows no NAMPT degradation capability at all^[1]. (Pink: NAMPT ligand (HY-50876); Blue: Ligands for E3 Ligase ligand (HY-W597583); Black: linker (HY-159018)).

All PROTACs Isoforms :

Chemical Information

CAS No. 3094092-93-7
Molecular Weight 840.06
Formula C₅₀H₆₁N₇O₅
SMILES

O=C(NCCCCC1CCN(C(C2=CC=C(N3CCN(CCCCCCC#CC4=CC=CC5=C4CN(C(CC6)C(N(C)C6=O)=O)C5=O)CC3)C=C2)=O)CC1)/C=C/C7=CC=CN=C7
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhu X, et al. Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation. Cell Chem Biol. 2022 Nov 17;29(11):1616-1629.e12. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SIAIS630121-NC

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SIAIS630121-NC Related Classifications

HY-159016 Related Classifications