SIAIS630120-NC
SIAIS630120-NC is a negative control PROTAC compound synthesized using a methylated CRBN ligand, which serves as a control for SIAIS630120. SIAIS630120-NC lacks NAMPT degradation activity. SIAIS630120-NC exerts no cytotoxic effect on hematological tumor cells.
(Pink: NAMPT ligand (HY-50876); Blue: Cereblon ligand (HY-W597583); Black: linker).
For research use only. We do not sell to patients.
- Formula: C49H59N7O5
- Molecular Weight:826.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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- References
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Biological Activity
SIAIS630120-NC (PROTAC-11-NC) (10 nM for 4 consecutive days), the negative control of SIAIS630120 (PROTAC-11), exhibits no antiproliferative activity against HL60 and MOLT4 hematologic tumor cells and completely lacks NAMPT degradation activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL60, MOLT4
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Concentration:10 nM
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Incubation Time:4 consecutive days
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Result:Showed no killing effect on HL60 or MOLT4 cells.
Exhibited cell survival comparable to untreated control cells.
Chemical Information
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Molecular Weight 826.04
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Formula C49H59N7O5
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SMILES
O=C(NCCCCC1CCN(C(C2=CC=C(N3CCN(CCCCCC#CC4=CC=CC5=C4CN(C(CC6)C(N(C)C6=O)=O)C5=O)CC3)C=C2)=O)CC1)/C=C/C7=CC=CN=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIAIS630120-NC Related Classifications
HY-159015 Related Classifications
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