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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Phosphoglycerate kinase
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Phosphoglycerate kinase" in MCE Product Catalog:
16
NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .
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3 Cited Publications
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Research Areas:
CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .
Research Areas:
Phosphoglycerate kinase (PGK), yeast is a monomeric glycolytic/gluconeogenic enzyme that can be found in Saccharomyces cerevisiae. Phosphoglycerate kinase, yeast catalyzes phosphoryl-group transfer from 1,3-bisphosphoglycerate to ADP to form 3-phosphoglycerate and ATP, binds 3PGA, ATP, and Mg 2+, and adopts a closed conformation. Phosphoglycerate kinase, yeast is commonly used in biochemical research .
Cat. No.: HY-N8540
CAS No.: 12689-26-8
Category:
Cat. No.: HY-178989
CAS No.: 3054148-68-1
Research Areas:
PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 μM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma .
Cat. No.: HY-15154R
CAS No.: 212779-48-1
Synonyms: Compound 52 (Standard)
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Research Areas:
NG 52 (Standard) is the analytical standard of NG 52. This product is intended for research and analytical applications. NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .
Cat. No.: HY-182811
CAS No.: 1241957-37-8
Research Areas:
AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 (hPgk1). AT-051/43421517 protects cells from rotenone-induced cell death without inducing cell proliferation. AT-051/43421517 can be used for the research of parkinson’s disease .
Cat. No.: HY-P75972
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PGK2; Phosphoglycerate kinase Autosomal Pseudogene; Phosphoglycerate kinase 2; Epididymis Secretory Protein Li 272; Phosphoglycerate kinase, Testis Specific; Testicular Tissue Protein Li 139; PGKPS; Phosphoglycerate kinase; PGK-2; DJ417L20.2; PGKB; HEL-S-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71049
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PGK1; PGKA; Phosphoglycerate kinase 1; Epididymis Secretory Sperm Binding Protein Li 68p; Cell Migration-Inducing Gene 10 Protein; Phosphoglycerate kinase; Primer Recognition Protein 2; HEL-S-68p; PRP 2; MIG10
Species:
Human
Source:
HEK293
Cat. No.: HY-P74634
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PGK1; PGKA; Phosphoglycerate kinase 1; Epididymis Secretory Sperm Binding Protein Li 68p; Cell Migration-Inducing Gene 10 Protein; Phosphoglycerate kinase; Primer Recognition Protein 2; HEL-S-68p; PRP 2; MIG10
Species:
Mouse
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
