AT-051/43421517
Based on 1 Customer Validation
AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 (hPgk1). AT-051/43421517 protects cells from rotenone-induced cell death without inducing cell proliferation. AT-051/43421517 can be used for the research of parkinson’s disease.
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 1241957-37-8
- Formula: C20H20N2O
- Molecular Weight:304.39
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
AT-051/43421517 binds to purified human phosphoglycerate kinase 1 (hPgk1) with a ChemScore of 33.379, occupying the same binding site as terazosin and forming characteristic hydrophobic interactions with key hPgk1 residues[1].
AT-051/43421517 (10 μM; 48 h) protects PC12 cells from rotenone-induced cell death, increasing cell viability to 87.97% of control without inducing cell proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:10 μM (co-incubation with rotenone; incubation alone)
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Incubation Time:48 h (co-incubation with rotenone; incubation alone)
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Result:Increased PC12 cell viability to 87.97% of control when co-treated with rotenone, a statistically significant improvement compared to the rotenone-only model group (73.84% of control).
Did not show a statistically significant improvement in cell viability when treated alone, ruling out cell proliferation as a contributor to the observed effect.
Chemical Information
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CAS No. 1241957-37-8
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Appearance Solid
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Molecular Weight 304.39
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Formula C20H20N2O
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Color Light yellow to yellow
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SMILES
CN(C)C(C=C1)=CC=C1/C=C/C2=C3C(C=CC=C3OC)=NC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 5 mg/mL (16.43 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2853 mL | 16.4263 mL | 32.8526 mL | 82.1315 mL |
| 5 mM | 0.6571 mL | 3.2853 mL | 6.5705 mL | 16.4263 mL | |
| 10 mM | 0.3285 mL | 1.6426 mL | 3.2853 mL | 8.2131 mL | |
| 15 mM | 0.2190 mL | 1.0951 mL | 2.1902 mL | 5.4754 mL |
AT-051/43421517 Related Classifications
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