2. MAPK/ERK Pathway Apoptosis
  3. MAP4K Apoptosis
  4. AT-051/43421517

AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 (hPgk1). AT-051/43421517 protects cells from rotenone-induced cell death without inducing cell proliferation. AT-051/43421517 can be used for the research of parkinson’s disease.

For research use only. We do not sell to patients.

AT-051/43421517

AT-051/43421517 Chemical Structure

CAS No. : 1241957-37-8

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AT-051/43421517 Related Antibodies

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Description

AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 (hPgk1). AT-051/43421517 protects cells from rotenone-induced cell death without inducing cell proliferation. AT-051/43421517 can be used for the research of parkinson’s disease[1].

In Vitro

AT-051/43421517 binds to purified human phosphoglycerate kinase 1 (hPgk1) with a ChemScore of 33.379, occupying the same binding site as terazosin and forming characteristic hydrophobic interactions with key hPgk1 residues[1].
AT-051/43421517 (10 μM; 48 h) protects PC12 cells from rotenone-induced cell death, increasing cell viability to 87.97% of control without inducing cell proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AT-051/43421517 Related Antibodies

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 10 μM (co-incubation with rotenone; incubation alone)
Incubation Time: 48 h (co-incubation with rotenone; incubation alone)
Result: Increased PC12 cell viability to 87.97% of control when co-treated with rotenone, a statistically significant improvement compared to the rotenone-only model group (73.84% of control).
Did not show a statistically significant improvement in cell viability when treated alone, ruling out cell proliferation as a contributor to the observed effect.
Molecular Weight

304.39

Formula

C20H20N2O
CAS No.
SMILES

CN(C)C(C=C1)=CC=C1/C=C/C2=C3C(C=CC=C3OC)=NC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AT-051/43421517 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AT-051/434215171241957-37-8MAP4KApoptosisMAPK Kinase Kinase Kinaseterazosinrotenoneparkinson’s diseasehuman phosphoglycerate kinase 1hPgk1PC12 cellsInhibitorinhibitorinhibit

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