1241957-37-8
Chemical Structure
AT-051/43421517
- CAS No.: 1241957-37-8
- Formula:C20H20N2O
- Molecular Weight:304.39
InChIKey: HHMBNJVUDHMGSO-JXMROGBWSA-N
SMILES: CN(C)C(C=C1)=CC=C1/C=C/C2=C3C(C=CC=C3OC)=NC=C2
Biological Activity: AT-051/43421517 is a PGK1 activator with a Kd of 2.45 μM. AT-051/43421517 induces enhanced glycolytic metabolism and maintains TCA cycle activity, while inhibiting ROS production and Apoptosis. AT-051/43421517 reduces Aβ deposition and Tau hyperphosphorylation. AT-051/43421517 alleviates neuropathological damage in the brains of 3×Tg-AD mice. AT-051/43421517 improves cognitive impairment. AT-051/43421517 can be used for research on Alzheimer's disease and Parkinson's disease[1][2].
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AT-051/43421517 | 99.71% | AT-051/43421517 is a PGK1 activator with a Kd of 2.45 μM. AT-051/43421517 induces enhanced glycolytic metabolism and maintains TCA cycle activity, while inhibiting ROS production and Apoptosis. AT-051/43421517 reduces Aβ deposition and Tau hyperphosphorylation. AT-051/43421517 alleviates neuropathological damage in the brains of 3×Tg-AD mice. AT-051/43421517 improves cognitive impairment. AT-051/43421517 can be used for research on Alzheimer's disease and Parkinson's disease. | ||||||||||||||||||||
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References
- [1]. Li M, et al. A novel PGK1 activator improves Alzheimer's disease by regulating glycolysis. Alzheimer's research & therapy. 2026 Mar 26;18(1):102.
- [2]. Xia J, et al. Virtual Screening against Phosphoglycerate Kinase 1 in Quest of Novel Apoptosis Inhibitors. Molecules (Basel, Switzerland). 2017 Jun 21;22(6):1029. [Content Brief]
